Patents by Inventor WIlliam George ROACH

WIlliam George ROACH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-IDIOTYPE ANTIBODIES
    Publication number: 20250019439
    Abstract: The present disclosure relates to anti-idiotypic antibodies binding to anti-CD3 antibodies, and uses thereof, e.g., in assays and methods of treatment.
    Type: Application
    Filed: November 22, 2022
    Publication date: January 16, 2025
    Inventor: William George ROACH
  • ANTI-C-MET TANDEM FC BISPECIFIC ANTIBODIES
    Publication number: 20170081421
    Abstract: Provided herein are tandem Fcs and tandem Fc antibodies (“TFcAs”), e.g., tandem Fc bispecific antibodies (“TFcBAs”), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs bind to the cell surface receptors c-Met and EpCam and inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.
    Type: Application
    Filed: September 30, 2016
    Publication date: March 23, 2017
    Inventors: Brian HARMS, Neeraj KOHLI, Alexey Alexandrovich LUGOVSKOY, Melissa GEDDIE, Eric Mark KRAULAND, William George ROACH, Stephen SU, Adnan ABU-YOUSIF
  • ANTI-C-MET tandem Fc bispecific antibodies
    Patent number: 9458245
    Abstract: Provided herein are tandem Fcs and tandem Fc antibodies (“TFcAs”), e.g., tandem Fc bispecific antibodies (“TFcBAs”), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs bind to the cell surface receptors c-Met and EpCam and inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 4, 2016
    Assignee: Merrimack Pharmaceuticals, Inc.
    Inventors: Brian Harms, Neeraj Kohli, Alexey Lugovskoy, Melissa Geddie, Eric Mark Krauland, William George Roach, Stephen Su, Adnan Abu-Yousif
  • ANTI-C-MET Tandem Fc Bispecific Antibodies
    Publication number: 20140302035
    Abstract: Provided herein are tandem Fcs and tandem Fc antibodies (“TFcAs”), e.g., tandem Fc bispecific antibodies (“TFcBAs”), which comprise one or at least two binding sites that specifically bind to one or more cell surface receptors. The binding sites are connected through a TFc, which TFc comprises a first Fc region and a second Fc region, wherein the first and the second Fc regions are linked through a TFc linker to form a contiguous polypeptide and dimerize to form an Fc dimer. Exemplary TFcBAs bind to the cell surface receptors c-Met and EpCam and inhibit signal transduction through the cell surface receptor(s) for which the binding sites of the TFcBA are specific.
    Type: Application
    Filed: March 6, 2014
    Publication date: October 9, 2014
    Applicants: ADIMAB, LLC, MERRIMACK PHARMACEUTICALS, INC.
    Inventors: Brian HARMS, Neeraj KOHLI, Alexey LUGOVSKOY, Melissa GEDDIE, Eric Mark KRAULAND, WIlliam George ROACH, Stephen SU, Adnan ABU-YOUSIF