Abstract: Systems and methods for controlling a tissue of a subject using applied pulsed electric fields. The system for controlling a therapy provided to a tissue of a subject using applied pulsed electric fields. The system includes an electrode assembly configured to engage a skin tissue of a subject to deliver a series of electric field pulses to the skin tissue and a user input configured to receive an operational instruction for the series of electric field pulses. The operational instruction defines at least one of a pulse duration, a pulse frequency, a pulse number, and a pulse amplitude. The system also includes at least one processor configured to access the operational instruction received by the user input and, using the operational instruction, create an electric field profile to be generated by the electrode assembly about the skin tissue of the subject to control a fibroblast characteristic while preserving a vascular perfusion in at least a portion of the skin tissue.

Abstract: Methods and systems useful in determining relative position of moveable vehicle, for example including a GPS receiver, may include determining candidate integer ambiguities in groups, and performing tests to check usefulness of those candidate integer ambiguities.

Abstract: Provided herein are constructs for genome editing or genetic engineering in fungi or protists, methods of using the constructs and media for use in selecting cells. The construct include a polynucleotide encoding a thymidine kinase operably connected to a promoter, suitably a constitutive promoter; a polynucleotide encoding an endonuclease operably connected to an inducible promoter; and a recognition site for the endonuclease. The constructs may also include selectable markers for use in selecting recombinations.

Abstract: A self-contained, hand-held spray dispensing device includes an internal source of pressurized fluid that exerts a motive force on a pair of liquid ejecting elements to cause each to eject a liquid into a discharge line. The liquids remain separated until each exits its discharge port. A pressurized fluid is directed over the outlet ends of the discharge line beginning before a flow interrupter in the discharge line is opened to permit flow therethrough and ceasing after liquid flow is terminated. The pressurized fluid flow over the outlet of the discharge line aerosolizes liquids emanating from the outlet ends. Each liquid ejecting element takes the form of a piston disposed within a cylinder. The pistons responds to pressurized fluid imposed directly thereon from the source to generate the motive force on the ejecting element.

Abstract: A gastrointestinal device and method for inserting the device are disclosed. The device may include a stent including a plurality of strands. The stent may move between an insertion configuration, wherein the plurality of strands are substantially parallel, and a deployed configuration, wherein the plurality of strands form a proximal portion having a first diameter and a distal portion having a second diameter. The first and second diameters may be larger than a diameter of the pyloric sphincter. The device may include a connector assembly including proximal and distal connectors attached to the strands. A cable including an engagement portion may be configured to releasably couple to the distal connector and to cause the strands to move from the insertion configuration to the deployed configuration when the engagement portion is coupled to the distal connector and force is applied to the cable in a direction toward the proximal connector.

Abstract: A gastrointestinal device and method for retrieving the device are disclosed. The device may include a stent including a plurality of strands forming first and second ends, the strands configured to move between a retrieval configuration, with substantially parallel strands, and a deployed configuration, wherein the strands form proximal and distal portions having first and second diameters larger than the pyloric sphincter. The device may include a connector assembly including proximal, middle, and distal connectors. The middle connector may be coupled to the proximal and distal connectors when the strands are in the deployed configuration. The strands may be attached to the proximal and distal connectors and the first and second ends. The device may include a release mechanism configured to decouple the proximal connector from the middle connector. Decoupling of the proximal and middle connectors may allow the strands to move from the deployed to retrieval configuration.

Abstract: A gastrointestinal device for reducing flow through a pyloric sphincter of a patient is disclosed. The device may include a stent including a plurality of strands forming first and second ends, the plurality of strands configured to form a proximal portion having a proximal diameter and a distal portion having a distal diameter. The proximal and distal diameters may be larger than a diameter of the pyloric sphincter and the proximal diameter may be larger than the distal diameter. The device may include a connector assembly including proximal and distal connectors, the plurality of strands being attached to the proximal and distal connectors at the first and second ends. The connector assembly may further include a middle portion extending between the proximal and distal connectors. The middle connector may extend within the plurality of strands, and may be unattached to the plurality of strands.

Abstract: A distributed and coordinated security system providing intrusion-detection and intrusion-prevention for the virtual machines (VMs) in a virtual server is described. The virtualization platform of the virtual server is enhanced with networking drivers that provide a “fast path” firewall function for pre-configured guest VMs that already have dedicated deep packet inspection security agents installed. A separate security VM is deployed to provide virtual security agents providing deep packet inspection for non pre-configured guest VMs. The network drivers are then configured to intercept the data traffic of these guest VMs and route it through their corresponding virtual security agents, thus providing a “slow-path” for intrusion detection and prevention.

Abstract: A vibratory apparatus includes a first sidewall, a second sidewall and at least one pair of mated interior walls, the first sidewall, the second sidewall and the at least one pair of mated interior walls depending longitudinally between an inlet end and an outlet end. The at least one pair of mated interior walls is disposed laterally between the first and second sidewalls. At least one deck depends between the first and second sidewalls, and is divided into longitudinally depending sections by the at least one pair of mated interior walls. The apparatus also includes an exciter coupled to the at least one deck.

Abstract: A method for continuously determining characteristics of a process fluid includes inline real-time analysis. In one embodiment, inline analysis of water, oil, and salt anions provides continuously obtained measurements for determination of various drilling fluid properties and assessment of drilling operation parameters and wellbore conditions. In one embodiment, the continuously provided measurements and/or data calculated therefrom allow for monitoring and controlling of a downhole drilling operation. In embodiments of the method, automated control of drilling operations using the continuously generated information can be accomplished. In one embodiment, a material balance of drilling fluid components using the continuously generated information is provided.

Abstract: Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.

Abstract: Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.

Abstract: A distributed and coordinated security system providing intrusion-detection and intrusion-prevention for the virtual machines (VMs) in a virtual server is described. The virtualization platform of the virtual server is enhanced with networking drivers that provide a “fast path” firewall function for pre-configured guest VMs that already have dedicated deep packet inspection security agents installed. A separate security VM is deployed to provide virtual security agents providing deep packet inspection for non pre-configured guest VMs. The network drivers are then configured to intercept the data traffic of these guest VMs and route it through their corresponding virtual security agents, thus providing a “slow-path” for intrusion detection and prevention.

Abstract: A mixing apparatus has a shaft, at least one arm radiating outwardly of the shaft, and a mixing element affixed to the arm away from the shaft. The mixing element has a generally frustoconical member with a wide opening at an end thereof and a narrow opening at an opposite end thereof. The mixing element also includes a throat section of a generally constant diameter connected to the narrow opening of the frustoconical member and a diffuser section having an end affixed to an end of the throat section opposite the frustoconical member. The mixing elements have a longitudinal axis extending at an acute angle to horizontal. A motor is cooperative with the shaft so as to rotate the shaft. Each of the mixing elements includes a Venturi.

Abstract: A distributed and coordinated security system providing intrusion-detection and intrusion-prevention for the virtual machines (VMs) in a virtual server is described. The virtualization platform of the virtual server is enhanced with networking drivers that provide a “fast path” firewall function for pre-configured guest VMs that already have dedicated deep packet inspection security agents installed. A separate security VM is deployed to provide virtual security agents providing deep packet inspection for non pre-configured guest VMs. The network drivers are then configured to intercept the data traffic of these guest VMs and route it through their corresponding virtual security agents, thus providing a “slow-path” for intrusion detection and prevention.

Abstract: The illustrative embodiments described herein provide a computer implemented method, apparatus, and computer program product for managing a flow model simulation. In an illustrative embodiment, annotated simulation settings are associated with a source model in response to receiving the source model. The annotated simulation settings are derived from at least one of a set of user-defined simulation settings and default simulation settings. The annotated source model is transformed into an internal domain model using a set of links that are generated using a set of link rules. The set of links maps a set of source model elements to a set of internal domain model elements of the internal domain model. Results from a simulation of the internal domain model are mapped back to the source model to identify a context for the results. Thereafter, a target view model is generated from the internal domain model. The target view model includes the results presented in the context of the source model.

Abstract: A device for dispensing individual components of a two-component adhesive includes first and second manifold members, each having a distribution chamber therein. A set of conveying tubes is supported within the dispensing device and collectively present a predetermined total cross-sectional flow area to the first distribution chamber. The second manifold member has an array of passages therethrough. Each tube extends substantially concentrically through a respective passage to define annular flow spaces that collectively present a predetermined total cross-sectional flow area to the second distribution chamber member. First and second components emanating from the tubes and the flow spaces are able to intermix with and diffuse into each other on the discharge area of the second manifold member. The cross-sectional flow areas presented to the first and second distribution chambers are equal.

Abstract: A device for dispensing individual components of a two-component adhesive includes first and second manifold members, each having a distribution chamber therein. A set of conveying tubes is supported within the dispensing device and collectively present a predetermined total cross-sectional flow area to the first distribution chamber. An array of openings and an array of passages extend through the second member. The openings receive the discharge ends of the conveying tubes. The passages are disposed in fluid communication with the second distribution chamber. The passages collectively present a predetermined total cross-sectional flow area to the second distribution chamber member. The openings and the passages are laterally spaced with respect to each other such that the discharge ends of the tubes are interspersed among the passages. The cross-sectional flow areas presented to the first and second distribution chambers are different.

Abstract: A self-contained, hand-held spray dispensing device includes an internal source of pressurized fluid that exerts a motive force on a pair of liquid ejecting elements to cause each to eject a liquid into a discharge line. The liquids remain separated until each exits its discharge port. A pressurized fluid is directed over the outlet ends of the discharge line beginning before a flow interrupter in the discharge line is opened to permit flow therethrough and ceasing after liquid flow is terminated. The pressurized fluid flow over the outlet of the discharge line aerosolizes liquids emanating from the outlet ends. The liquid ejecting element is connected to a force transmitting yoke. The yoke responds to pressurized fluid from the source to generate the motive force on the ejecting element.

Abstract: An apparatus includes a thermally conductive section with a side facing approximately parallel to an axis and adapted to be thermally coupled to a circuit component, and includes a fluid supply section which directs a fluid flow along the axis toward an opposite side of the thermally conductive section. The thermally conductive section splits the fluid flow into a plurality of flow portions which each flow through the thermally conductive section in a direction approximately parallel to a plane perpendicular to the axis, the flow portions exiting the thermally conductive section at a plurality of respective locations disposed along a substantial portion of the periphery of the thermally conductive section.