Patents by Inventor William Gerwick

William Gerwick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200078437
    Abstract: Methods and pharmaceutical compositions for treating malaria and immune related disorders are provided. The pharmaceutical compositions include an effective amount a carmaphycin B analog that inhibits immunoproteasome activity in a subject.
    Type: Application
    Filed: May 15, 2018
    Publication date: March 12, 2020
    Inventors: William Gerwick, Betsaida Bibo Verdugo, Anthony O'Donoghue, Jehad Almaliti
  • Publication number: 20160143971
    Abstract: Methods for using botanical compositions comprising administration of non-alcoholic organic extracts of Ganoderma lucidum, Salvia miltiorrhiza, and Scutellaria barbata in conjunction with docetaxel for cancer therapy, are provided. Method for treatment or therapy of prostate cancer in a human is provided, the method comprising: administering an effective amount of the botanical composition during a period of administering concurrently an effective amount of docetaxel, wherein the concurrent administration of the docetaxel and the botanical composition achieves a therapeutic effect that is more effective than either agent alone.
    Type: Application
    Filed: June 3, 2014
    Publication date: May 26, 2016
    Inventors: James DAO, Jeffery DAO, William GERWICK, Lena GERWICK, MaryAnn JORDAN, Leslie WILSON
  • Patent number: 9073884
    Abstract: The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: July 7, 2015
    Assignees: The Regents of the University of California, University of Rhode Island Research Foundation
    Inventors: William Gerwick, Lena Gerwick, Hyuakjae Choi, Francisco Villa, Jennifer Smith, David C Rowley
  • Patent number: 9045401
    Abstract: The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: June 2, 2015
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: William Gerwick, Wolfgang Wrasidlo, Dennis Carson, Dwayne Stupack, Takashi Suyama
  • Publication number: 20140147481
    Abstract: The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.
    Type: Application
    Filed: June 3, 2011
    Publication date: May 29, 2014
    Applicants: UNIVERSITY OF RHODE ISLAND RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: William Gerwick, Lena Gerwick, Huykjae Choi, Francisco Villa, Jennifer Smith, David C Rowley
  • Publication number: 20130101616
    Abstract: Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
    Type: Application
    Filed: April 12, 2012
    Publication date: April 25, 2013
    Inventors: James DAO, Tom C.S. DAO, David D. TONG, Leslie WILSON, Mary Ann JORDAN, William GERWICK
  • Patent number: 8173177
    Abstract: Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: May 8, 2012
    Assignee: Genyous Biomed International Inc.
    Inventors: James Dao, Tom C. S. Dao, David D. Tong, Leslie Wilson, Mary Ann Jordan, William Gerwick
  • Publication number: 20110117121
    Abstract: Methods and compositions for therapy of pain are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Compositions exhibit multiple functions that are useful for the treatment of pain and inflammation. Compositions of the invention inhibit the activity of COX-2 to a greater extent than COX-1. Compositions of the invention also inhibit the nuclear accumulation of NF-kappaB and thus inhibit the expression of a number of proinflammatory molecules including COX-2.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 19, 2011
    Inventors: James Dao, Jeff Dao, Leslie Wilson, William Gerwick, Emin Oroudjev
  • Publication number: 20100266675
    Abstract: The invention provides novel compositions—lipopeptides and analogs, including somocystinamide A, and somocystinamide A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these lipopeptides and analogs are used to induce apoptosis in a cell, which can be a normal cell, a dysfunctional cell and/or a cancer (tumor) cell. In alternative embodiments, the compositions of the invention, including the lipopeptides and analogs of the invention, and the pharmaceutical compositions comprising them, are used to treat or ameliorate (including slowing the progression of) normal, dysfunctional (e.g., abnormally proliferating) and/or tumor associated blood vessels, including endothelial and/or capillary cell growth; including neovasculature related to (within, providing a blood supply to) a tumor.
    Type: Application
    Filed: May 21, 2008
    Publication date: October 21, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: William Gerwick, Wolfgang Wrasidlo, Dennis Carson, Dwayne Stupack, Takashi Suyama
  • Publication number: 20050208070
    Abstract: Methods and compositions for prevention and therapy of cancer are provided. Compositions comprising therapeutically effective amounts of two or more of an extract of Ganoderma lucidum, an extract of Salvia miltiorrhiza and an extract of Scutellaria barbata and optionally a therapeutically effective amount of an extract of Hippophae rhamnoides are provided. Novel synergistic effects of the use of these compounds in combination therapy are disclosed. Embodiments further comprising therapeutically effective amounts of at least one chemotherapeutic agent are also provided.
    Type: Application
    Filed: September 8, 2004
    Publication date: September 22, 2005
    Inventors: James Dao, Tom Dao, David Tong, Leslie Wilson, Mary Jordan, William Gerwick
  • Publication number: 20050074834
    Abstract: Living cells can be used to identify or quantify bioactive conditions, including without limitation, chemicals, biological pathogens, and environmental conditions, such as pH, in samples based on changes in, for example, cell color, morphology and/or physiology. Such changes can be directly detected or detected with the aid of instrumentation. One embodiment of the method comprises exposing a system to a bioactive condition, such as a chemical agent, a biological pathogen, an environmental condition, such as pH, etc., and combinations of such conditions. The system then exhibits a response to the bioactive condition. The response of the system, or a portion thereof, to the bioactive condition is then represented, such as by digital images. The method then involves attempting to classify a scenario by database comparison. Classification can be in terms of numeric or non-numerical classifiers. Typically, the system comprises living cells.
    Type: Application
    Filed: March 12, 2004
    Publication date: April 7, 2005
    Inventors: Frank Chaplen, William Gerwick, Goran Jovanovic, Wojtek Kolodziej, Jim Liburdy, Phil McFadden, Brian Paul, Thomas Plant, Janine Trempy, Nicolas Roussel, Corwin Willard, Rosalyn Upson, Andrzej Pacut