Abstract: A pumped heat storage apparatus has a prime mover, a power take off, first and second fluid working machines functioning as a compressor (8) and as an expander (10), a working fluid circulation pathway with high and low pressure sides, and high and low temperature heat exchangers (18A-B). The heat exchangers operate using direct contact between gaseous working fluid and solid thermal storage media, such as glass beads, which move in opposite directions, typically using an augur (44). The system is reversible between energy storage and energy recovery modes and when it reverses, the direction of movement of the working fluid and the thermal storage media reverses. The apparatus may very rapidly swap between energy storage and energy recovery while having a high capacity and energy throughout.

Abstract: Multiplexed phased array sonar systems and methods for consumer fishfinders are described herein. In one embodiment a single curved transmit transducer and an array of receive transducers are provided, and in an embodiment the signals from the receive transducers are multiplexed, which greatly reduces the data load, allowing for the achievement of the near real time, high resolution imagery in a size and price point that enables this technology to be employed in a consumer fish finder.

Abstract: Remote control system is disclosed. The present techniques relate to a system and a method for improving connection between two devices, e.g. to enable one device to control the other. The method comprises receiving, at a remote computing device, a request from a secondary user device to diagnose a fault with the primary user device. The request is received on a first communication channel. The method further comprises a step of connecting, in response to the request, the remote computing device with the secondary user device. This is performed by using a secure communication channel which is different to the first communication channel. The method further comprises a step of sending a command message for the primary user device from the remote computing device to the secondary user device via the secure communication channel. Any response to the command message is then received from the secondary user device via the secure communication channel. The response is used at least in part to diagnose the fault.

Abstract: A nucleic acid molecule comprising a nucleotide sequence encoding an inhibitory chimeric antigen receptor (iCAR) capable of preventing or attenuating undesired activation of an effector immune cell, wherein the iCAR comprises an extracellular domain that specifically binds to a single allelic variant of a polymorphic cell surface epitope absent from mammalian tumor cells due to loss of heterozygosity (LOH) but present at least on all cells of related mammalian normal tissue; and an intracellular domain comprising at least one signal transduction element that inhibits an effector immune cell is provided. Vectors and transduced effector immune cells comprising the nucleic acid molecule and methods for treatment of cancer comprising administering the transduced effector immune cells are further provided.

Abstract: The invention relates to a system for sorting veneer sheets. The system comprises: an assembly section; a reject section; a feeding section arranged between the assembly section and the reject section; at least one detection device configured to scan a top surface of a topmost veneer sheet of a stack of veneer sheets to provide a plurality of successive scan lines images; at least two parallel transfer devices; and a control system.

Abstract: The present disclosure relates to absorbent articles with waist panels configured with physical properties for mitigating assembly complications. In some configurations, a waist panel comprises a longitudinal bending stiffness with peak load of at least about 0.19 N; a machine direction web modulus at 2% of at least about 72 N/%; a tensile load at peak of at least about 7 N/cm, as measured according to a MD tensile test; and/or a thickness of least about 0.4 mm, as measured according to Thickness Test. Such physical properties may help prevent and/or reduce instances of manufacturing problems and/or defective products during assembly by: enhancing the ability to consistently cut desired machine direction lengths of waist panels; reducing the possibility of a waist panel to undesirably fold back onto itself during assembly; enhancing the ability to absorb heat without damage and more consistently transfer discrete elastic parts between transformation apparatuses.

Abstract: A method for applying a polymeric composition discharged in a fluid form from a slot die applicator to a substrate, the slot die applicator including a slot opening, a first lip, and a second lip, the slot opening located between the first lip and the second lip; and the substrate having a first surface disposed opposite of a second surface and an unconstrained caliper, Hs, the method comprising the steps of positioning the substrate carrier adjacent the slot die applicator to define a minimum distance, Hg, between the substrate carrier and the first lip and the second lip that is substantially the same or less than the unconstrained caliper, Hs, of the substrate. The polymeric composition has Tensile Strength at Yield of from about 0.5 MPa to about 10 MPa, as measured according to the Tensile Strength Test Method described herein.

Abstract: The invention relates to a system for sorting veneer sheets. The system comprises: an assembly section; a reject section; a feeding section arranged between the assembly section and the reject section; at least one detection device configured to scan a top surface of a topmost veneer sheet of a stack of veneer sheets to provide a plurality of successive scan lines images; at least two parallel transfer devices; and a control system.

Abstract: Methods for limiting dissipation of neurotoxins and dermal fillers from an injection site are disclosed, which includes applying a repellant electric field to the skin around the injection site to limit dissipation of an injected neurotoxin or dermal filler.

Abstract: Remote control system is disclosed. The present techniques relate to a system and a method for improving connection between two devices, e.g. to enable one device to control the other. The method comprises receiving, at a remote computing device, a request from a secondary user device to diagnose a fault with the primary user device. The request is received on a first communication channel. The method further comprises a step of connecting, in response to the request, the remote computing device with the secondary user device. This is performed by using a secure communication channel which is different to the first communication channel. The method further comprises a step of sending a command message for the primary user device from the remote computing device to the secondary user device via the secure communication channel Any response to the command message is then received from the secondary user device via the secure communication channel. The response is used at least in part to diagnose the fault.

Abstract: A nucleic acid molecule comprising a nucleotide sequence encoding an inhibitory chimeric antigen receptor (i CAR) capable of preventing or attenuating undesired activation of an effector immune cell, wherein the i CAR comprises an extracellular domain that specifically binds to a single allelic variant of a polymorphic cell surface epitope absent from mammalian tumor cells due to loss of heterozygosity (LOH) but present at least on all cells of related mammalian normal tissue; and an intracellular domain comprising at least one signal transduction element that inhibits an effector immune cell is provided. Vectors and transduced effector immune cells comprising the nucleic acid molecule and methods for treatment of cancer comprising administering the transduced effector immune cells are further provided.

Abstract: Methods for localizing a composition to a treatment site, which includes placing at least two electrodes against a skin surface where dissipation of the composition is to be limited, wherein the at least two electrodes do not penetrate the skin surface; subcutaneously or intramuscularly injecting the composition, which has a net negative or net positive charge at physiological pH, between the at least two electrodes or underneath one of the at least two electrodes; and applying a positive charge to one of the at least two electrodes and a negative charge to another of the at least two electrodes to produce a directional electric field that limits dissipation of the injected composition.

Abstract: The present invention is directed to 4?-substituted nucleoside derivatives of Formula I and their use in the inhibition of HIV reverse transcriptase, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS and/or ARC. The present invention also provides processes for the preparation of 4?-substituted nucleoside derivatives of Formula I and derivatives thereof.

Abstract: Detecting postoperative complications in a patient uses a substrate made of biocompatible or biodegradable material. An adhesive layer adheres the substrate to patient tissue, surgical tool, or medical device. A biosensor at the substrate detects or measures an analyte in the patient's body. The biosensor may be on the surface of the substrate or within a microchannel in the substrate. A separation or isolation structure may be provided to separate or isolate the analyte from other analytes prior to the biosensor. A microcontroller is disposed on the substrate and connected to the biosensor and to a wireless communications interface also disposed on the substrate. The microcontroller measures a signal from the biosensor and may perform an analysis on the measured signal. Measured data or data resulting from the analysis is transmitted through the wireless communications interface to a transdermal patch or other remote device for storage and display.

Abstract: A turn signal reset device for a signal switch assembly of a vehicle includes a return stalk, a tab, and an actuator. A coupler is coupled to a first end of the return stalk and is configured to couple the return stalk to a signal stalk of a signal switch assembly that is coupled to a steering column of a vehicle. A second end of the return stalk, to which the actuator is coupled, is positioned proximate to the steering column. A connector that is coupled to the tab is configured to couple the tab to the steering column so that the tab extends radially from the steering column. Activating the signal stalk positions the actuator to selectively engage the tab as the steering column rotates. The actuator is configured to actuate the signal stalk to reset the signal switch assembly to a neutral configuration.

Abstract: Methods for limiting dissipation of neurotoxins and dermal fillers from an injection site are disclosed, which includes applying a repellant electric field to the skin around the injection site to limit dissipation of an injected neurotoxin or dermal filler.

Abstract: A turn signal reset device for a signal switch assembly of a vehicle includes a return stalk, a tab, and an actuator. A coupler is coupled to a first end of the return stalk and is configured to couple the return stalk to a signal stalk of a signal switch assembly that is coupled to a steering column of a vehicle. A second end of the return stalk, to which the actuator is coupled, is positioned proximate to the steering column. A connector that is coupled to the tab is configured to couple the tab to the steering column so that the tab extends radially from the steering column. Activating the signal stalk positions the actuator to selectively engage the tab as the steering column rotates. The actuator is configured to actuate the signal stalk to reset the signal switch assembly to a neutral configuration.

Abstract: A device for detecting exposure to light includes: a photo-responsive layer including a photochromic material; a skin-mimicking cover layer covering a first side of the photo-responsive layer; and an adhesive layer configured to couple a second side of the photo-responsive layer opposite the first side to a surface.

Abstract: A nucleic acid molecule comprising a nucleotide sequence encoding an inhibitory chimeric antigen receptor (i CAR) capable of preventing or attenuating undesired activation of an effector immune cell, wherein the i CAR comprises an extracellular domain that specifically binds to a single allelic variant of a polymorphic cell surface epitope absent from mammalian tumor cells due to loss of heterozygosity (LOH) but present at least on all cells of related mammalian normal tissue; and an intracellular domain comprising at least one signal transduction element that inhibits an effector immune cell is provided. Vectors and transduced effector immune cells comprising the nucleic acid molecule and methods for treatment of cancer comprising administering the transduced effector immune cells are further provided.

Abstract: The child-restraining harness and bib is a safety device. The child-restraining harness and bib is further configured for use with a person selected from the group consisting of an infant and a toddler. The child-restraining harness and bib is configured for use with a chair. The child-restraining harness and bib secures the person to the chair. The child-restraining harness and bib comprises the body harness and the bib. The body harness attaches the person to the chair. The bib stores the body harness when the body harness is not in use. The bib is worn by the person to protect the clothing worn by the person when the body harness is in use.