Abstract: This invention relates to copolymers which consist essentially of [-ether-phenyl-ether-phenyl-carbonyl-phenyl-]and [ether-phenyl-phenyl-ether-phenyl-carbonyl-phenyl-] repeat units, as well as end units, which have reduced melting temperature (Tm) compared to prior art copolymers including such repeat units. The copolymers of the invention exhibit crystallinity and have similar glass transition temperatures to the prior art polymers.

Abstract: Provided herein are antibodies that specifically bind to human tissue factor (TF), anti-TF antibody-drug conjugates (ADCs), and compositions comprising the antibodies or ADCs for treatment of inflammatory diseases. Also provided herein are methods of treating subjects having inflammatory diseases by administering the anti-TF antibodies or ADCs.

Abstract: This invention relates to copolymers which consist essentially of [-ether-phenyl-ether-phenyl-carbonyl-phenyl-]and [ether-phenyl-phenyl-ether-phenyl-carbonyl-phenyl-] repeat units, as well as end units, which have reduced melting temperature (Tm) compared to prior art copolymers including such repeat units. The copolymers of the invention exhibit crystallinity and have similar glass transition temperatures to the prior art polymers.

Abstract: Provided herein are methods and immunoconjugate dimer compositions for the treatment of diseases associated with angiogenesis and neovascularization. In one aspect, the invention relates to a method for treating wet age-related macular degeneration (AMD) in an eye of a patient in need thereof. The method comprises administering to the patient in multiple dosing sessions, a composition comprising an effective amount of an immunoconjugate dimer, wherein the monomer subunits of the dimer each comprises a mutated human factor VIIa (fVIIa) protein conjugated to the human immunoglobulin G1 (IgG1) Fc domain.

Abstract: The systems, apparatus, methods, and computer program products described herein provide the capability to convert physical debt instruments into digital representations, and to completely manage all aspects of the instruments lifecycle digitally. This allows for real-time update of debt clauses and covenants at a very low cost. Furthermore, the digital representations create immutable histories, which simplify and streamline the process of auditing, confirming legal compliance, and performing due diligence for syndication or securitization. The systems, apparatus, methods, and computer program products described herein further provide automatic updates of key metrics from disparate data sources, notarization of contractual changes, and automated disbursement of funds or creation of new asset classes.

Abstract: A method for automatically enrolling a smart-home device in a demand-response program includes receiving an identification of a user account that is sent from a utility provider computer system based on an agreement that the smart-home device will be enrolled in the demand-response program. The identification of the user account is also sent to indicate to the device management server that the smart-home device should be sent to a location associated with the user account. The method also includes causing the smart-home device to be sent to the location associated with the user account. The method additionally includes receiving an indication from the smart-home device that the smart-home device has been installed at the location associated with the user account, and enrolling the smart-home device in the demand-response program.

Abstract: A method of optimizing sleep of a subject using smart-home devices may include operating a smart-home system that is configured to operate in a normal mode and a sleep mode. The method may also include determining that the smart-home system should transition into the sleep mode. The smart-home devices may use a set of default parameters when operating in the sleep mode. The method may additionally include monitoring, while in the sleep mode, a sleep cycle of the subject using the smart-home devices. The method may further include detecting behavior of the subject that indicates that the sleep cycle of the subject is being interrupted or about to be interrupted, determining an environmental control that corresponds with the behavior of the subject, and adjusting the environmental control using the smart-home devices to prevent or stop the sleep cycle of the subject from being interrupted.

Abstract: Various arrangements are presented for issuing an alert based on a baby's behavior. A video stream that images a baby may be received. The video stream may be analyzed to determine the baby is in a non-auditory discomfort state. A notification may be determined to be output to a caregiver based on the determined non-auditory discomfort state. An alert may be output that is indicative of the non-auditory discomfort state to an end-user device.

Abstract: Provided herein are methods and compositions for the treatment of diseases associated with angiogenesis and neovascularization. In one aspect, the invention relates to a method for treating a condition in an eye of a patient in need thereof comprising administering to the patient in multiple dosing sessions, an effective amount of an immunoconjugate dimer, wherein the monomer subunits of the dimer each comprises a mutated human factor VIIa (fVIIa) protein conjugated to the human immunoglobulin G1 (IgG1) Fc domain and a VEGF inhibitor, wherein the administration results in an improved outcome compared to a patient having been administered the VEGF inhibitor alone.

Abstract: A method for automatically enrolling a smart-home device in a demand-response program includes receiving an identification of a user account that is sent from a utility provider computer system based on an agreement that the smart-home device will be enrolled in the demand-response program. The identification of the user account is also sent to indicate to the device management server that the smart-home device should be sent to a location associated with the user account. The method also includes causing the smart-home device to be sent to the location associated with the user account. The method additionally includes receiving an indication from the smart-home device that the smart-home device has been installed at the location associated with the user account, and enrolling the smart-home device in the demand-response program.

Abstract: Various arrangements are presented for issuing an alert based on a baby's behavior. A video stream that images a baby may be received. The video stream may be analyzed to determine the baby is in a non-auditory discomfort state. A notification may be determined to be output to a caregiver based on the determined non-auditory discomfort state. An alert may be output that is indicative of the non-auditory discomfort state to an end-user device.

Abstract: A method for automatically enrolling a smart-home device in a demand-response program includes receiving an identification of a user account that is sent from a utility provider computer system based on an agreement that the smart-home device will be enrolled in the demand-response program. The identification of the user account is also sent to indicate to the device management server that the smart-home device should be sent to a location associated with the user account. The method also includes causing the smart-home device to be sent to the location associated with the user account. The method additionally includes receiving an indication from the smart-home device that the smart-home device has been installed at the location associated with the user account, and enrolling the smart-home device in the demand-response program.

Abstract: A method of optimizing sleep of a subject using smart-home devices may include operating a smart-home system that is configured to operate in a normal mode and a sleep mode. The method may also include determining that the smart-home system should transition into the sleep mode. The smart-home devices may use a set of default parameters when operating in the sleep mode. The method may additionally include monitoring, while in the sleep mode, a sleep cycle of the subject using the smart-home devices. The method may further include detecting behavior of the subject that indicates that the sleep cycle of the subject is being interrupted or about to be interrupted, determining an environmental control that corresponds with the behavior of the subject, and adjusting the environmental control using the smart-home devices to prevent or stop the sleep cycle of the subject from being interrupted.

Abstract: A thermostat my include a stored setpoint schedule, temperature sensors providing temperature sensor measurements; and a processing system configured to control an HVAC system based at least in part on the setpoint temperature and the temperature sensor measurements. The processing system may be configured to control the HVAC system by receiving an indication of a first time interval, where energy is available to the HVAC system at a first rate during the first time interval, energy is available to the HVAC system at a second rate during a second time interval that is outside of the first time interval, and the first rate is higher than the second rate; identifying a first one or more setpoints in the plurality of setpoints of the stored setpoint schedule that occur in the first time interval; and decreasing a temperature component of at least one of the first one or more setpoints.

Abstract: Provided herein are immunoconjugate dimers for the treatment of disorders associated with neovascularization and tumor-associated neovascularization (e.g ocular melanoma) and symptoms associated with the same. The methods comprises administering to the patient in one or more dosing sessions, a composition comprising an effective amount of any one or more of the immunoconjugate dimers of the invention, wherein the monomer subunits of the dimer each comprises a mutated factor VIIa (FVIIa) protein conjugated to a immunoglobulin G1 (IgG1) Fc domain.

Abstract: A method for automatically enrolling a smart-home device in a demand-response program includes receiving an identification of a user account that is sent from a utility provider computer system based on an agreement that the smart-home device will be enrolled in the demand-response program. The identification of the user account is also sent to indicate to the device management server that the smart-home device should be sent to a location associated with the user account. The method also includes causing the smart-home device to be sent to the location associated with the user account. The method additionally includes receiving an indication from the smart-home device that the smart-home device has been installed at the location associated with the user account, and enrolling the smart-home device in the demand-response program.

Abstract: Provided herein are methods and immunoconjugate dimer compositions for the treatment of diseases associated with angiogenesis and neovascularization. In one aspect, the invention relates to a method for treating wet age-related macular degeneration (AMD) in an eye of a patient in need thereof. The method comprises administering to the patient in multiple dosing sessions, a composition comprising an effective amount of an immunoconjugate dimer, wherein the monomer subunits of the dimer each comprises a mutated human factor VIIa (fVIIa) protein conjugated to the human immunoglobulin G1 (IgG1) Fc domain.

Abstract: A method for authorizing a smart-home device for enrollment with a demand-response program may include receiving, at a control server of an energy management system and for the smart-home device, identifying information for a user account. The method may also include sending the identifying information from the control server to an Application Program Interface (API) with an enrollment request. The method may additionally include receiving, at the control server, a determination from the API as to whether the identifying information for the user account was matched to an existing utility account. The method may further include based on the determination from the API, determining whether the smart-home device can be enrolled with the demand-response program.

Abstract: A thermostat my include a stored setpoint schedule, temperature sensors providing temperature sensor measurements; and a processing system configured to control an HVAC system based at least in part on the setpoint temperature and the temperature sensor measurements. The processing system may be configured to control the HVAC system by receiving an indication of a first time interval, where energy is available to the HVAC system at a first rate during the first time interval, energy is available to the HVAC system at a second rate during a second time interval that is outside of the first time interval, and the first rate is higher than the second rate; identifying a first one or more setpoints in the plurality of setpoints of the stored setpoint schedule that occur in the first time interval; and decreasing a temperature component of at least one of the first one or more setpoints.

Abstract: A non-oxidized diesel desulfurization process that uses temperature swing adsorption along with an adsorbent to adsorb sulfur compounds and other impurities petroleum-based from fuel compositions, including light distillates, middle distillates, diesel, gasoline and transmix. The process uses temperature cycling of an adsorbent bed to adsorb and desorb organosulfur compounds and other impurities. Once the adsorbent reaches a selected concentration of sulfur compounds, the temperature of the adsorbent bed is raised to desorb sulfur compounds, using a regenerant.