Patents by Inventor William H. Chandler
William H. Chandler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6692708Abstract: An apparatus for parallel processing of reaction mixtures, including a reactor block including reaction chambers for containing reaction mixtures under pressure, the reactor block further including a first sidewall, a second sidewall, and a first plurality of fluid flow paths providing fluid communication with the first sidewall and respective reaction chambers and the second sidewall and respective reaction chambers; a stirring system including a base plate defining a second plurality of flow paths, wherein respective flow paths of said second plurality of flow paths are in fluid communication with respective reaction chambers and respective fluid flow paths of said first plurality of flow paths, and the base plate also supports a plurality of stirring blade assemblies for mixing the reaction mixtures; interchangeable manifolds supported by the first sidewall and the second sidewall, the interchangeable manifolds defining a plurality of manifold inlet/outlet ports, wherein respective inlet/outlet ports of saType: GrantFiled: April 5, 2001Date of Patent: February 17, 2004Assignee: Symyx Technologies, Inc.Inventor: William H. Chandler, Jr.
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Publication number: 20030202911Abstract: An apparatus and method for synthesis and screening of materials are disclosed. According to one aspect of the present invention, a parallel batch reactor for effecting chemical reactions includes a pressure chamber, an inlet port, two or more reaction vessels within the pressure chamber, and a reaction vessel cover. The inlet port is in fluid communication with the pressure chamber, and pressurizes the pressure chamber from an external pressure source. Each of the two or more reaction vessels are in isolatable fluid communication with the pressure chamber such that during a first pressurizing stage of operation, each of the two or more reaction vessels can be simultaneously pressurized through common fluid communication with the pressure chamber. In addition, during at least a second reaction stage of operation, each of the two or more pressurized reaction vessels can be isolated from each other by positioning the reaction vessel cover appropriately.Type: ApplicationFiled: December 12, 2002Publication date: October 30, 2003Applicant: Symyx Technologies, Inc.Inventors: Lynn Van Erden, William H. Chandler
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Publication number: 20030190260Abstract: A combinatorial chemistry reactor system for the parallel processing of reaction mixtures. The system comprises a frame, a head mounted in fixed position on the frame, and a reactor block having a plurality of wells therein for containing reaction mixtures. The reactor block is movable with respect to the head between a first position in which the reactor block and head are assembled for conducting reactions in the wells and a second position in which the reactor block is removed from the head for providing access to the vessels. Gaps in the reactor block between the wells serve to thermally isolate the wells from one another. Other features relating to pressure relief, reactor block temperature control, and sensor mounting are also disclosed.Type: ApplicationFiled: April 5, 2002Publication date: October 9, 2003Applicant: Symyx Technologies, Inc.Inventors: Tony N. Wheeler, Lynn Van Erden, William H. Chandler, Richard Tiede, Robert J. Saxton, Anil Guram
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Publication number: 20030161763Abstract: An apparatus and method for synthesis and screening of materials are disclosed. According to one aspect of the present invention, a parallel batch reactor for effecting chemical reactions includes a pressure chamber, an inlet port, and two or more reaction vessels within the pressure chamber. The inlet port is in fluid communication with the pressure chamber, and is used for pressurizing the pressure chamber from an external pressure source. Each of the two or more reaction vessels are in isolatable fluid communication with the pressure chamber such that during a first pressurizing stage of operation, each of the two or more reaction vessels can be simultaneously pressurized through common fluid communication with the pressure chamber. In addition, during at least a second reaction stage of operation, each of the two or more pressurized reaction vessels can be isolated from each other.Type: ApplicationFiled: January 21, 2003Publication date: August 28, 2003Applicant: Symyx Technologies, Inc.Inventors: Lynn Van Erden, William H. Chandler
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Publication number: 20030124028Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.Type: ApplicationFiled: May 24, 2002Publication date: July 3, 2003Inventors: Eric D. Carlson, Peijun Cong, William H. Chandler, Henry K. Chau, Earl Danielson, Peter J. Desrosiers, Robert D. Doolen, Luping Wu, C. Eric Ramberg, Thomas Crevier, Ralph B. Nielsen, Colin S. Masui, John F. Varni
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Publication number: 20030118078Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.Type: ApplicationFiled: May 24, 2002Publication date: June 26, 2003Inventors: Eric D. Carlson, Peijun Cong, William H. Chandler, Peter J. Desrosiers, Robert D. Doolen, J. Christopher Freitag
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Publication number: 20030116497Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.Type: ApplicationFiled: May 24, 2002Publication date: June 26, 2003Inventors: Eric D. Carlson, Peijun Cong, William H. Chandler, Peter J. Desrosiers, J. Christopher Freitag, John F. Varni
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Publication number: 20030045000Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber is disclosed. The apparatus includes a reaction chamber for receiving one or more libraries, each of the libraries comprising two or more samples. The reaction chamber is configured to form a sealed enclosure. The apparatus further includes an injection manifold supporting injectors for in-situ injection of one or more chemical components onto respective samples of the one or more libraries in the pressurized sealed reaction chamber.Type: ApplicationFiled: June 28, 2002Publication date: March 6, 2003Applicant: SYMYX TECHNOLOGIES, INC.Inventors: Trevor G. Frank, Keith A. Hall, William H. Chandler, Thomas Boussie, Thomas J. Crevier, Leonid Matsiev, Christopher Goh
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Publication number: 20030003017Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber, comprising a reaction chamber for receiving one or more libraries including two or more samples; an injection module in fluid communication with the reaction chamber for permitting in-situ injection of one or more chemical components into the reaction chamber; and a selectively movable transport assembly supported by at least a portion of the reaction chamber for transporting the one or more libraries to the injection module.Type: ApplicationFiled: June 29, 2001Publication date: January 2, 2003Applicant: Symyx Technologies, Inc.Inventors: Trevor G. Frank, Keith A. Hall, William H. Chandler, Thomas Boussie, Thomas J. Crevier, Leonid F. Matsiev
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Publication number: 20020172631Abstract: An apparatus for parallel processing of reaction mixtures, including a reactor block including reaction chambers for containing reaction mixtures under pressure, the reactor block further including a first sidewall, a second sidewall, and a first plurality of fluid flow paths providing fluid communication with the first sidewall and respective reaction chambers and the second sidewall and respective reaction chambers; a stirring system including a base plate defining a second plurality of flow paths, wherein respective flow paths of said second plurality of flow paths are in fluid communication with respective reaction chambers and respective fluid flow paths of said first plurality of flow paths, and the base plate also supports a plurality of stirring blade assemblies for mixing the reaction mixtures; interchangeable manifolds supported by the first sidewall and the second sidewall, the interchangeable manifolds defining a plurality of manifold inlet/outlet ports, wherein respective inlet/outlet ports of saType: ApplicationFiled: April 5, 2001Publication date: November 21, 2002Applicant: Symyx Technologies, Inc.Inventor: William H. Chandler
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Publication number: 20020164275Abstract: A combinatorial chemistry reactor system for the parallel processing of reaction mixtures. The system comprises a frame, a head mounted in fixed position on the frame, and a reactor block having a plurality of wells therein for containing reaction mixtures. The reactor block is movable with respect to the head between a first position in which the reactor block and head are assembled for conducting reactions in the wells and a second position in which the reactor block is removed from the head for providing access to the vessels. Gaps in the reactor block between the wells serve to thermally isolate the wells from one another. Other features relating to pressure relief, reactor block temperature control, and sensor mounting are also disclosed.Type: ApplicationFiled: April 5, 2002Publication date: November 7, 2002Applicant: Symyx Technologies, Inc.Inventors: Tony Wheeler, Lynn Van Erden, William H. Chandler, Richard Tiede, Robert J. Saxton, Anil Guram
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Publication number: 20010034067Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including slurries, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.Type: ApplicationFiled: January 26, 2001Publication date: October 25, 2001Inventors: G. Cameron Dales, Jonah R. Troth, Kenneth S. Higashihara, Gary Diamond, Vince Murphy, William H. Chandler, Trevor G. Frank, J. Christopher Freitag
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Patent number: 5088677Abstract: The holders are attachable to the edges of planar support surfaces for music and serve to hold the music in place against the effects of wind, gravity and characteristics of the music material. Each holder comprises attachment apparatus and a spring arm extending from it to contact the music. In a preferred embodiment the spring comprises an arm portion and a pivot portion which, when the spring is relaxed, is at an 80.degree. angle to the arm portion. The pivot portion is carried in a hole in the attachment apparatus, the hole and pivot portion being inclined at a 3.degree. angle off of normal to the planar support surface angled toward the leafed material. The arm portion can thus be pivoted so that its end is either in or clear of the locations in which music is placed to be held.Type: GrantFiled: December 11, 1989Date of Patent: February 18, 1992Inventors: William H. Chandler, Francis D. Reynolds