Patents by Inventor William H. Grover
William H. Grover has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220187185Abstract: A method for of validating the identity of one of more component(s) in a substance including: obtaining a substance; placing the substance in a plenum with a sealed bottom; exposing the substance to a perturbation; digitally recoding the time-dependent changes in the substance after exposing the substance to the perturbation; producing a chronological fingerprint of the changes, where the chronological fingerprint is a digital multi-dimensional image of the changes as a function of time; and comparing the chronological fingerprint to chronological fingerprints for known substances to validate the one or more component(s) in the substance being measured. Also described are associated systems and computer program products for implementing the method.Type: ApplicationFiled: March 17, 2020Publication date: June 16, 2022Inventors: William H. Grover, Brittney A. McKenzie
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Patent number: 10201964Abstract: A method of reducing the toxicity of a 3D-printed part is provided. The method includes exposing the part to ultraviolet light sufficient to reduce the toxicity of the part. The toxicity of the ultraviolet light-treated part can be based on a comparison with the toxicity of a similarly prepared part not exposed to ultraviolet light.Type: GrantFiled: November 2, 2016Date of Patent: February 12, 2019Assignee: The Regents of the University of CaliforniaInventors: William H. Grover, Shirin Mesbah Oskui
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Patent number: 9651039Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.Type: GrantFiled: September 3, 2008Date of Patent: May 16, 2017Assignee: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Alison Skelley, Eric Lagally, Chung N. Liu
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Patent number: 9644623Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.Type: GrantFiled: May 18, 2010Date of Patent: May 9, 2017Assignee: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Alison Skelley, Eric Lagally, Chung N. Liu
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Publication number: 20170120523Abstract: A method of reducing the toxicity of a 3D-printed part is provided. The method includes exposing the part to ultraviolet light sufficient to reduce the toxicity of the part. The toxicity of the ultraviolet light-treated part can be based on a comparison with the toxicity of a similarly prepared part not exposed to ultraviolet light.Type: ApplicationFiled: November 2, 2016Publication date: May 4, 2017Applicant: The Regents of the University of CaliforniaInventors: William H. Grover, Shirin Mesbah Oskui
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Patent number: 8312763Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.Type: GrantFiled: October 14, 2009Date of Patent: November 20, 2012Assignee: Massachusetts Institute of TechnologyInventors: Scott R. Manalis, Andrea K. Bryan, Philip Dextras, Thomas P. Burg, William H. Grover, Yao-Chung Weng, Sungmin Son
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Patent number: 8286665Abstract: Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.Type: GrantFiled: June 18, 2010Date of Patent: October 16, 2012Assignee: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Erik C. Jensen
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Publication number: 20100297747Abstract: Microsystem for monitoring cell growth. A microfluidic structure is designed to allow cells to circulate therethrough and the microfluidic structure includes modules to monitor mass, mass density and fluorescence of the cell.Type: ApplicationFiled: October 24, 2008Publication date: November 25, 2010Inventors: Scott R. Manalis, Andrea K. Bryan, Yao-Chung Weng, Thomas Burg, William H. Grover, Marc W. Kirschner, Paul Jorgensen, Michel Godin
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Publication number: 20100252123Abstract: Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.Type: ApplicationFiled: June 18, 2010Publication date: October 7, 2010Applicant: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Erik C. Jensen
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Publication number: 20100224255Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.Type: ApplicationFiled: May 18, 2010Publication date: September 9, 2010Applicant: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Brian Paegel, Alison Skelley, Eric Lagally, Chung N. Liu, Robert Blazej
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Patent number: 7766033Abstract: Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.Type: GrantFiled: March 21, 2007Date of Patent: August 3, 2010Assignee: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Erik C. Jensen
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Publication number: 20100154535Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.Type: ApplicationFiled: October 14, 2009Publication date: June 24, 2010Inventors: Scott R. Manalis, Andrea K. Bryan, Philip Dextras, Thomas P. Burg, William H. Grover, Yao-Chung Weng, Sungmin Son
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Publication number: 20090060797Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.Type: ApplicationFiled: September 3, 2008Publication date: March 5, 2009Applicant: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Brian Paegel, Alison Skelley, Eric Lagally, Chung N. Liu, Robert Blazej
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Patent number: 7445926Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.Type: GrantFiled: December 29, 2003Date of Patent: November 4, 2008Assignee: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Alison Skelley, Eric Lagally, Chung N. Liu
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Publication number: 20040209354Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.Type: ApplicationFiled: December 29, 2003Publication date: October 21, 2004Applicant: The Regents of the University of CaliforniaInventors: Richard A. Mathies, William H. Grover, Brian Paegel, Alison Skelley, Eric Lagally, Chung N. Liu, Robert Blazej