Patents by Inventor William H. Grover

William H. Grover has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220187185
    Abstract: A method for of validating the identity of one of more component(s) in a substance including: obtaining a substance; placing the substance in a plenum with a sealed bottom; exposing the substance to a perturbation; digitally recoding the time-dependent changes in the substance after exposing the substance to the perturbation; producing a chronological fingerprint of the changes, where the chronological fingerprint is a digital multi-dimensional image of the changes as a function of time; and comparing the chronological fingerprint to chronological fingerprints for known substances to validate the one or more component(s) in the substance being measured. Also described are associated systems and computer program products for implementing the method.
    Type: Application
    Filed: March 17, 2020
    Publication date: June 16, 2022
    Inventors: William H. Grover, Brittney A. McKenzie
  • Patent number: 10201964
    Abstract: A method of reducing the toxicity of a 3D-printed part is provided. The method includes exposing the part to ultraviolet light sufficient to reduce the toxicity of the part. The toxicity of the ultraviolet light-treated part can be based on a comparison with the toxicity of a similarly prepared part not exposed to ultraviolet light.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: February 12, 2019
    Assignee: The Regents of the University of California
    Inventors: William H. Grover, Shirin Mesbah Oskui
  • Patent number: 9651039
    Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
    Type: Grant
    Filed: September 3, 2008
    Date of Patent: May 16, 2017
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Alison Skelley, Eric Lagally, Chung N. Liu
  • Patent number: 9644623
    Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: May 9, 2017
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Alison Skelley, Eric Lagally, Chung N. Liu
  • Publication number: 20170120523
    Abstract: A method of reducing the toxicity of a 3D-printed part is provided. The method includes exposing the part to ultraviolet light sufficient to reduce the toxicity of the part. The toxicity of the ultraviolet light-treated part can be based on a comparison with the toxicity of a similarly prepared part not exposed to ultraviolet light.
    Type: Application
    Filed: November 2, 2016
    Publication date: May 4, 2017
    Applicant: The Regents of the University of California
    Inventors: William H. Grover, Shirin Mesbah Oskui
  • Patent number: 8312763
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: November 20, 2012
    Assignee: Massachusetts Institute of Technology
    Inventors: Scott R. Manalis, Andrea K. Bryan, Philip Dextras, Thomas P. Burg, William H. Grover, Yao-Chung Weng, Sungmin Son
  • Patent number: 8286665
    Abstract: Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: October 16, 2012
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Erik C. Jensen
  • Publication number: 20100297747
    Abstract: Microsystem for monitoring cell growth. A microfluidic structure is designed to allow cells to circulate therethrough and the microfluidic structure includes modules to monitor mass, mass density and fluorescence of the cell.
    Type: Application
    Filed: October 24, 2008
    Publication date: November 25, 2010
    Inventors: Scott R. Manalis, Andrea K. Bryan, Yao-Chung Weng, Thomas Burg, William H. Grover, Marc W. Kirschner, Paul Jorgensen, Michel Godin
  • Publication number: 20100252123
    Abstract: Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.
    Type: Application
    Filed: June 18, 2010
    Publication date: October 7, 2010
    Applicant: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Erik C. Jensen
  • Publication number: 20100224255
    Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
    Type: Application
    Filed: May 18, 2010
    Publication date: September 9, 2010
    Applicant: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Brian Paegel, Alison Skelley, Eric Lagally, Chung N. Liu, Robert Blazej
  • Patent number: 7766033
    Abstract: Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: August 3, 2010
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Erik C. Jensen
  • Publication number: 20100154535
    Abstract: Methods and apparatus for improving measurements of particle or cell characteristics, such as mass, in Susppended Microchannel Resonators (SMR's). Apparatus include in particular designs for trapping particles in SMR's for extended measurement periods. Methods include techniques to provide differential measurements by varying the fluid density for repeated measurements on the same particle or cell.
    Type: Application
    Filed: October 14, 2009
    Publication date: June 24, 2010
    Inventors: Scott R. Manalis, Andrea K. Bryan, Philip Dextras, Thomas P. Burg, William H. Grover, Yao-Chung Weng, Sungmin Son
  • Publication number: 20090060797
    Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
    Type: Application
    Filed: September 3, 2008
    Publication date: March 5, 2009
    Applicant: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Brian Paegel, Alison Skelley, Eric Lagally, Chung N. Liu, Robert Blazej
  • Patent number: 7445926
    Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
    Type: Grant
    Filed: December 29, 2003
    Date of Patent: November 4, 2008
    Assignee: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Alison Skelley, Eric Lagally, Chung N. Liu
  • Publication number: 20040209354
    Abstract: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of a variety of fluid control structures, such as structures for pumping, isolating, mixing, routing, merging, splitting, preparing, and storing volumes of fluid. The fluid control structures can be used to implement a variety of sample introduction, preparation, processing, and storage techniques.
    Type: Application
    Filed: December 29, 2003
    Publication date: October 21, 2004
    Applicant: The Regents of the University of California
    Inventors: Richard A. Mathies, William H. Grover, Brian Paegel, Alison Skelley, Eric Lagally, Chung N. Liu, Robert Blazej