Abstract: There are disclosed compounds of the formula ##STR1## R is --CH.sub.2 OH or --CO.sub.2 R.sup.3 ; R.sup.1 is hydrogen, lower alkyl, lower alkoxy or hydroxybenzyl;R.sup.2 is hydroxyloweralkyl or diloweralkoxyalkyl;R.sup.3 is hydrogen or lower alkyl;R.sup.4 is alkyl of 10-20 carbons atoms, phenylalkyl of 11-18 carbon atoms or phenoxyalkyl of 11-18 carbon atoms; orn is 1-3;or a pharmaceutically acceptable salt thereof, and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivitis and various inflammatory conditions.

Abstract: There are disclosed compounds of the formulaR.sup.1 -XwhereinR.sup.1 is alkyl of 8-22 carbon atoms;X is ##STR1## R.sup.2 is --(CH.sub.2).sub.n NR.sup.4 R.sup.5 ; R.sup.3 is hydrogen or lower alkyl;R.sup.4 is hydrogen or lower alkyl;R.sup.5 is hydrogen or lower alkyl; andn is 0-7, with the proviso that when X is ##STR2## n is 6-7; and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivitis and various inflammatory conditions.

Abstract: There are disclosed compounds of the formula ##STR1## wherein R.sup.1 is lower alkyl, lower alkoxycarbonyl lower alkyl, aralkoxycarbonyl, aralkoxycarbonyl lower alkyl or indol-2-yllower alkyl;R.sup.2 is hydrogen, lower alkyl or biphenylyl lower alkylcarbonyl; orR.sup.1 and R.sup.2 taken together form a 5- or 6-membered saturated heterocyclic ring;R.sup.3 is hydrogen or lower alkyl;R.sup.4 is alkyl of 10-20 carbon atoms, cycloalkyl of 10-20 carbon atoms or phenylalkyl of 10-16 carbon atoms; orR.sup.3 and R.sup.4 taken are decahydroisoquinolin-2-yl, 3,5-dimethylpiperazin-1-yl or 3,3,5-trimethylhexahydroazepin-1-yl;or a pharmaceutically acceptable salt thereof, and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivities and various inflammatory conditions.

Abstract: There are disclosed compounds of the formulaR.sup.1 --XwhereinR.sup.1 is alkyl of 8-22 carbon atoms;X is ##STR1## and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivitis and various inflammatory conditions.

Abstract: The polypeptides R-Gly-L-Cys-Gly-L-Glu-L-Glu-NH.sub.2 or a pharmaceutically acceptable salt thereof act as collagenase inhibitors useful in the treatment of disease involving excessive tissue destruction by collagenase.

Abstract: The polypeptidesX--R.sub.1 --R.sub.2 --[R.sub.3 ].sub.n --NH.sub.2whereX is hydrogen, alkanoyl of 2 to 6 carbon atoms, cycloalkylcarbonyl of 6 to 8 carbon atoms or alkoxycarbonyl of 2 to 6 carbon atoms;R.sub.1 is Cys-, 3-mercapto-Val-, p-Glu-Cys-, p-Glu-3-mercapto-Val- or Pro-Gln-Gly-;R.sub.2 is Leu-, Ile- or Val-;R.sub.3 is Ala-, Ala-Gly- or Ala-Gly-Arg-; andn is 0 or 1;or a pharmaceutically acceptable salt thereof act as collagenase inhibitors useful in the treatment of diseases involving excessive tissue destruction by collagenase.

Abstract: The polypeptides ##STR1## in which R is hydrogen, alkanoyl of 2 to 6 carbon atoms, cycloalkylcarbonyl of 2 to 6 carbon atoms or a pharmaceutically acceptable salt thereof act as collagenase inhibitors useful in the treatment of diseases involving excessive tissue destruction by collagenase.

Abstract: There are disclosed polypeptides having the formula:R.sub.1 --Lys--Lys--X--R.sub.2wherein R.sub.1 is hydrogen or p-Glu; X is Glu or Asp; and R.sub.2 is Val, NH.sub.2 or Val-NH.sub.2 ; the fully protected peptide-resin intermediates thereof and pharmaceutically acceptable salts thereof. These polypeptides have the capability of inducing the maturation of T-cell populations and thus are useful in a number of therapeutic areas.

Abstract: Bestatin and its analogues are compounds capable of inducing analgesia in mammals when administered peripherally.

Abstract: There are disclosed tetrapeptides having the formula:R.sub.1 -Ser-His-Leu-R.sub.2wherein R.sub.1 is N-lower alkanoyl or N-lower alkanoylGly; R.sub.2 is NH.sub.2 or Val-NH.sub.2 ; the fully protected peptide-resin intermediates thereof and pharmaceutically acceptable salts thereof. These tetrapeptides have the capability of inducing the proliferation of T-cell populations and thus are useful in a number of therapeutic areas.

Abstract: Novel dipeptides of the formula: A--X--Y--B wherein X is D-Tyr or L-Tyr; Y is D-Ala, L-Ala, D-Ser, L-Ser, or Gly; with the proviso that at least one of X and Y is of the D- configuration; A is hydrogen, allyl, or lower alkyl of 1 to 3 carbon atoms; B is --NH.sub.2, --OMe, or --NHNH.sub.2 ; and the pharmacologically acceptable salts thereof, as well as pharmaceutical compositions containing them, and a process for antagonizing the effects of a narcotic analgesic agent in warm blooded animals are disclosed.

Abstract: The polypeptides of the formula: ##STR1## in which R is hydrogen, methyl, allyl or cyclopropylmethyl; andR.sup.2 is --OH, --NH.sub.2 or --NHC.sub.n H.sub.2n+1 whereN is 1,2,3 or 4Or a pharmaceutically acceptable salt thereof, exert an analgesic effect in warm-blooded animals when peripherally administered.

Abstract: The growth hormone release inhibiting undecapeptide of the formulaN.alpha.-(3-mercaptopropionyl)-L-Lys-L-Asn-L-Phe-L-Phe-L-Trp-L-Lys-L-Thr-L- Phe-L-Thr-L-Ser-L-Cys cyclic (1-11) disulfide.

Abstract: High speed liquid chromatography of synthetically produced somatostatin yields somatostatin free from structural artifacts.