Patents by Inventor William H. Ralston
William H. Ralston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6419897Abstract: A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.Type: GrantFiled: July 25, 2000Date of Patent: July 16, 2002Assignee: Arizona Board of RegentsInventors: John Devens Gust, Jr., Ana L. Moore, Thomas A. Moore, William H. Ralston
-
Patent number: 6274729Abstract: A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.Type: GrantFiled: February 1, 2000Date of Patent: August 14, 2001Assignee: Arizona Board of RegentsInventors: John Devens Gust, Jr., Ana L. Moore, Thomas A. Moore, William H. Ralston
-
Patent number: 6207821Abstract: A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.Type: GrantFiled: February 1, 2000Date of Patent: March 27, 2001Assignee: Arizona Board of RegentsInventors: John Devens Gust, Jr., Ana L. Moore, Thomas A. Moore, William H. Ralston
-
Patent number: 6183727Abstract: A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.Type: GrantFiled: April 1, 1999Date of Patent: February 6, 2001Assignee: Arizona Board of RegentsInventors: John Devens Gust, Jr., Ana L. Moore, Thomas A. Moore, William H. Ralston
-
Patent number: 5690908Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: November 13, 1995Date of Patent: November 25, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet Braddock Wilking, Linda Meeh, Steven R. Woulfe
-
Patent number: 5609850Abstract: Treated apatite particles are disclosed for enhancing radical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: August 22, 1995Date of Patent: March 11, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe
-
Patent number: 5595724Abstract: Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.Type: GrantFiled: January 13, 1995Date of Patent: January 21, 1997Inventors: Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco, William H. Ralston, David H. White, Janet B. Wilking, Robert G. Wolfangel, Steven R. Woulfe, William P. Cacheris, Linda Meeh
-
Patent number: 5567411Abstract: Dendritic derivatives of 3,5-bis(aminomethyl)benzene and aminomethyl benzene core groups are disclosed. In each derivative, termed an "amplifier" because the dendritic structure on each molecule terminates with multiple termini to each of which an "active group" can be attached, the desired effect of the active group per mole is amplified compared to conventional compounds having only one active group per molecule. Amplifier molecules can include a targeting group permitting the molecules to preferentially attach to a particular anatomical or physiological situs. Active groups are any of various pharmacologically or therapeutically active moieties, including moieties useful for magnetic-resonance contrast enhancement. The dendritic structures comprise linkers and branch groups covalently bonded to each other in any of various structural combinations. The amplifiers can be prepared as a solution or mixture with a physiologically compatible carrier for administration to a warm-blooded animal subject.Type: GrantFiled: September 29, 1994Date of Patent: October 22, 1996Assignee: State of Oregon Acting by and Through the State Board of Higher Education on Behalf of the University of OregonInventors: John F. W. Keana, Vladimir Martin, William H. Ralston
-
Patent number: 5468465Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging (37 MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: July 6, 1994Date of Patent: November 21, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe
-
Patent number: 5407659Abstract: Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.Type: GrantFiled: April 13, 1993Date of Patent: April 18, 1995Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, Dennis L. Nosco, William H. Ralston, David H. White, Janet B. Wilking, Robert G. Wolfangel, Steven R. Woulfe
-
Patent number: 5344640Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: September 22, 1992Date of Patent: September 6, 1994Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet B. Wilking, Linda Meeh, Steven R. Woulfe