Patents by Inventor William H. Tepp

William H. Tepp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Clostridial Neurotoxins as Vaccine and Conjugate Vaccine Platforms
    Publication number: 20240139332
    Abstract: Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.
    Type: Application
    Filed: October 3, 2022
    Publication date: May 2, 2024
    Inventors: Joseph T. Barbieri, Eric A. Johnson, Sabine Pellett, William H. Tepp, Amanda Przedpelski
  • Modified clostridial neurotoxins as vaccines and conjugate vaccine platforms
    Patent number: 11491239
    Abstract: Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: November 8, 2022
    Assignees: The Medical College of Wisconsin, Inc., Wisconsin Alumni Research Foundation
    Inventors: Joseph T. Barbieri, Eric A. Johnson, Sabine Pellett, William H. Tepp, Amanda Przedpelski
  • COVID-19 VACCINE
    Publication number: 20210300970
    Abstract: Provided herein are antigenic peptides comprising the SARS-CoV-2 spike protein receptor binding domain (CRBD) polypeptide or portions thereof, linked to a non-catalytic, non-toxic tetanus toxin variant (i.e., a modified tetanus toxin or “MTT”) and vaccine compositions comprising the same. In addition, provided herein are methods for making and using CRBD-MTT fusion proteins as immunogenic agents.
    Type: Application
    Filed: March 24, 2021
    Publication date: September 30, 2021
    Inventors: Joseph T. Barbieri, Amanda Przedpelski, Eric A. Johnson, Sabine Pellett, William H. Tepp
  • MODIFIED CLOSTRIDIAL NEUROTOXINS AS VACCINES AND CONJUGATE VACCINE PLATFORMS
    Publication number: 20200384120
    Abstract: Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.
    Type: Application
    Filed: December 17, 2018
    Publication date: December 10, 2020
    Applicants: THE MEDICAL COLLEGE OF WISCONSIN, INC., WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Joseph T. Barbieri, Eric A. Johnson, Sabine Pellett, William H. Tepp, Amanda Przedpelski
  • Neurotoxins and uses thereof
    Patent number: 10751394
    Abstract: The present disclosure relates to neurotoxins and uses thereof. In particular, provided herein are botulinum neurotoxins with altered properties and uses thereof (e.g., research, screening, and therapeutic uses).
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: August 25, 2020
    Assignee: CELLSNAP LLC
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Christina Pier, Marite Bradshaw
  • Hybrid neurotoxins and uses thereof
    Patent number: 10688162
    Abstract: The present disclosure relates to chimeric neurotoxins and uses thereof. In particular, provided herein are chimeric botulinum neurotoxins with altered properties and uses thereof (e.g., research, screening, and therapeutic uses).
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: June 23, 2020
    Assignee: CELLSNAP LLC
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Marite Bradshaw, Christina L. Pier, Joseph T. Barbieri
  • Regulation of specific spinal neurons regulating pain transmission via chimeric toxins
    Patent number: 10022450
    Abstract: A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: July 17, 2018
    Assignees: Wisconsin Alumni Research Foundation, The Regents of the University of California
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Tony L. Yaksh, Marc Marino, Qinghao Xu
  • HYBRID NEUROTOXINS AND USES THEREOF
    Publication number: 20180193435
    Abstract: The present disclosure relates to chimeric neurotoxins and uses thereof. In particular, provided herein are chimeric botulinum neurotoxins with altered properties and uses thereof (e.g., research, screening, and therapeutic uses).
    Type: Application
    Filed: January 10, 2018
    Publication date: July 12, 2018
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Marite Bradshaw, Christina L. Pier, Joseph T. Barbieri
  • NEUROTOXINS AND USES THEREOF
    Publication number: 20180117129
    Abstract: The present disclosure relates to neurotoxins and uses thereof. In particular, provided herein are botulinum neurotoxins with altered properties and uses thereof (e.g., research, screening, and therapeutic uses).
    Type: Application
    Filed: October 25, 2017
    Publication date: May 3, 2018
    Inventors: ERIC A. JOHNSON, SABINE PELLETT, WILLIAM H. TEPP, CHRISTINA PIER, MARITE BRADSHAW
  • Regulation of Specific Spinal Neurons Regulating Pain Transmission
    Publication number: 20160361429
    Abstract: A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
    Type: Application
    Filed: August 19, 2016
    Publication date: December 15, 2016
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Tony L. Yaksh, Marc Marino, Qinghao Xu
  • Regulation of specific spinal neurons regulating pain transmission via chimeric toxins
    Patent number: 9447405
    Abstract: A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: September 20, 2016
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Tony L. Yaksh, Marc Marino, Qinghao Xu
  • Method of detecting botulinum neurotoxin and antibodies that neutralize botulinum neurotoxin action
    Patent number: 8940477
    Abstract: A highly sensitive method of analyzing a sample for the presence or activity of botulinum neurotoxin (BoNT) or antibodies specific for botulinum neurotoxin is disclosed. In one embodiment, the method comprises the steps of preparing primary non-human mammalian or avian spinal cord cells, and exposing the cells to a test sample, in parallel with a control sample, and examining the extent of cleavage of the intracellular neuronal target protein in both the test and control sample.
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: January 27, 2015
    Assignees: Wisconsin Alumni Research Foundation
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Gary E. Borodic, David J. Beebe, Amy Paguirigan
  • Regulation of Specific Spinal Neurons Regulating Pain Transmission
    Publication number: 20140255376
    Abstract: A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
    Type: Application
    Filed: February 14, 2014
    Publication date: September 11, 2014
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Tony L. Yaksh, Marc Marino, Qinghao Xu
  • Subtype of neurotoxin type A and uses thereof
    Patent number: 8440204
    Abstract: A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: May 14, 2013
    Assignees: Wisconsin Alumni Research Foundation, The Scripps Research Institute
    Inventors: Eric A. Johnson, Mark Joseph Jacobson, Guangyun Lin, Raymond C. Stevens, Jerome Dupuy, P{dot over (a)}l Erik Gustav Stenmark, William H. Tepp
  • Method of detecting botulinum neurotoxin and antibodies that neutralize botulinum neurotoxin action
    Publication number: 20120164657
    Abstract: A highly sensitive method of analyzing a sample for the presence or activity of botulinum neurotoxin (BoNT) or antibodies specific for botulinum neurotoxin is disclosed. In one embodiment, the method comprises the steps of preparing primary non-human mammalian or avian spinal cord cells, and exposing the cells to a test sample, in parallel with a control sample, and examining the extent of cleavage of the intracellular neuronal target protein in both the test and control sample.
    Type: Application
    Filed: November 10, 2008
    Publication date: June 28, 2012
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Gary E. Borodic, David J. Beebe, Amy Paguirigan
  • Novel Subtype of Closteridium Botulinum Neurotoxin Type A and Uses Thereof
    Publication number: 20110171226
    Abstract: A novel subtype of type A botulinum neurotoxin (BoNT/A) is disclosed in the application. Methods to purify the neurotoxin as well as uses thereof are also disclosed.
    Type: Application
    Filed: April 29, 2010
    Publication date: July 14, 2011
    Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: ERIC A. JOHNSON, MARK JOSEPH JACOBSON, GUANGYUN LIN, RAYMOND C. STEVENS, JEROME DUPUY, Pal Erik Gustav STENMARK, WILLIAM H. TEPP
  • -derived vaccine and therapy against botulism
    Patent number: 7820411
    Abstract: A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture media, and (c) purifying the HCR protein via extraction, wherein the extraction comprises a clarification by centrifugation and a filtration, wherein the purified HCR protein is at least 10 mg/L of culture medium.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: October 26, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael Baldwin, Marite Bradshaw, William H. Tepp, Eric A. Johnson, Joseph T. Barbieri, Christina L. Pier
  • ESCHERICHIA COLI-DERIVED VACCINE AND THERAPY AGAINST BOTULISM
    Publication number: 20090017495
    Abstract: A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture media, and (c) purifying the HCR protein via extraction, wherein the extraction comprises a clarification by centrifugation and a filtration, wherein the purified HCR protein is at least 10 mg/L of culture medium.
    Type: Application
    Filed: February 29, 2008
    Publication date: January 15, 2009
    Inventors: Michael Baldwin, Eric A. Johnson, Joseph T. Barbieri, Marite Bradshaw, William H. Tepp, Christina L. Pier
  • Method of targeting pharmaceuticals to motor neurons
    Patent number: 6670322
    Abstract: A method of targeting therapeutic molecules to motor neurons is disclosed. In one embodiment, this method comprises the steps of (a) synthesizing a prodrug comprising a therapeutic molecule covalently bound to a polymeric delivery vehicle, and (b) conjugating the prodrug to a botulinum neurotoxin heavy chain.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: December 30, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael C. Goodnough, Eric A. Johnson, William H. Tepp, Carl J. Malizio
  • Method of targeting pharmaceuticals to motor neurons
    Publication number: 20030147921
    Abstract: A method of targeting therapeutic molecules to motor neurons is disclosed. In one embodiment, this method comprises the steps of (a) synthesizing a prodrug comprising a therapeutic molecule covalently bound to a polymeric delivery vehicle, and (b) conjugating the prodrug to a botulinum neurotoxin heavy chain.
    Type: Application
    Filed: May 30, 2001
    Publication date: August 7, 2003
    Inventors: Michael C. Goodnough, Eric A. Johnson, William H. Tepp, Carl J. Malizio