Abstract: Light source for an inline sensor having one or more solid state UV emitters for emitting light at single wavelengths in the range of 240 to 400 nm. The light emitted by each of the emitters has a bandwidth on the order of 10-20 nm and is directed toward a measurement detector in the inline sensor. The UV emitters are enclosed in a housing which can be attached to the inline sensor, with a reference detector and a regulator for the UV emitters also within the housing, and an aperture through which the light passes from the emitters to the measurement detector. In some embodiments, air cooling is provided for the UV emitters.

Abstract: Light source for an inline sensor having one or more solid state UV emitters for emitting light at single wavelengths in the range of 240 to 400 nm. The light emitted by each of the emitters has a bandwidth on the order of 10-20 nm and is directed toward a measurement detector in the inline sensor. The UV emitters are enclosed in a housing which can be attached to the inline sensor, with a reference detector and a regulator for the UV emitters also within the housing, and an aperture through which the light passes from the emitters to the measurement detector.

Abstract: Micro volume inline optical sensor comprising a flowcell having a sample chamber which has a volume less than 0.4 mL and increases in diameter from two ends toward the middle, a flow passageway intersecting the chamber where the diameter is the greatest, monitoring ports with optically transmissive windows at the ends of the chamber, mounting rings on opposite sides of the flowcell disposed coaxially of an optical axis that passes through the monitoring ports and the sample chamber, and a light source and an optical detector mounted on the mounting rings in alignment with each other along the optical axis. In one embodiment, the sample chamber has a side wall with oppositely inclined frusto-conical sections, and the ends of the chamber are closed and sealed by the monitoring port windows and O-ring gaskets that surround the open ends and are compressed between the body of the flowcell and the windows.

Abstract: Inline optical sensor which includes a modular flowcell block with a flow passageway of predetermined diameter, interchangeable adapters for connecting flow lines with different internal diameters to the block, and an optical pathlength that can be adjusted both in fixed increments with window spacers and continuously with vernier adjusters, and a light source and an optical detector in modular housings which can be aligned both radially and axially. Thermal isolation is provided between the housings and the flowcell body, and air circulation further reduces temperature and condensation within the housings.

Abstract: Light source for an inline sensor having one or more solid state UV emitters for emitting light at single wavelengths in the range of 240 to 400 nm. The light emitted by each of the emitters has a bandwidth on the order of 10-20 nm and is directed toward a measurement detector in the inline sensor. The UV emitters are enclosed in a housing which can be attached to the inline sensor, with a reference detector and a regulator for the UV emitters also within the housing, and an aperture through which the light passes from the emitters to the measurement detector. In some embodiments, air cooling is provided for the UV emitters.

Abstract: Micro volume inline optical sensor comprising a flowcell having a sample chamber which has a volume less than 0.4 mL and increases in diameter from two ends toward the middle, a flow passageway intersecting the chamber where the diameter is the greatest, monitoring ports with optically transmissive windows at the ends of the chamber, mounting rings on opposite sides of the flowcell disposed coaxially of an optical axis that passes through the monitoring ports and the sample chamber, and a light source and an optical detector mounted on the mounting rings in alignment with each other along the optical axis. In one embodiment, the sample chamber has a side wall with oppositely inclined frusto-conical sections, and the ends of the chamber are closed and sealed by the monitoring port windows and O-ring gaskets that surround the open ends and are compressed between the body of the flowcell and the windows.

Abstract: Self-aligning light source and detector assembly having a sensor support mounted in a predetermined, fixed position, a light source holder mounted in a predetermined, fixed position relative to the sensor support, a sensor mounted in a fixed position on the sensor support, and a lamp assembly removably mounted to the light source holder in a predetermined position defined by mating surfaces which engage each other and seat the lamp assembly in the predetermined position whenever the lamp assembly is installed in the holder.

Abstract: Self-aligning light source and detector assembly having a sensor support mounted in a predetermined, fixed position, a light source holder mounted in a predetermined, fixed position relative to the sensor support, a sensor mounted in a fixed position on the sensor support, and a lamp assembly removably mounted to the light source holder in a predetermined position defined by mating surfaces which engage each other and seat the lamp assembly in the predetermined position whenever the lamp assembly is installed in the holder.

Abstract: Inline optical sensor which includes a modular flowcell block with a flow passageway of predetermined diameter, interchangeable adapters for connecting flow lines with different internal diameters to the block, and an optical pathlength that can be adjusted both in fixed increments with window spacers and continuously with vernier adjusters, and a light source and an optical detector in modular housings which can be aligned both radially and axially. Thermal isolation is provided between the housings and the flowcell body, and air circulation further reduces temperature and condensation within the housings.

Abstract: Manifold and probe assembly for use a bioprocessing vessel. The manifold has a chamber which communicates with the interior of the vessel and a plurality of ports which communicate with the chamber. Elongated sensing probes are threadedly connected to the ports with end portions of the probes extending into the chamber. Gaskets having generally annular bodies with conically inclined beveled faces are mounted on the end portions of the probes, with the beveled faces engaging conically inclined surfaces of seats in the ports and the gaskets being axially compressed and radially expanded into sealing engagement with the probes. The seating surfaces have inner and outer sections with different angles of inclination which produce greater radial expansion and tighter sealing with the probes.

Abstract: Self-aligning light source and detector assembly having a sensor support mounted in a predetermined, fixed position, a light source holder mounted in a predetermined, fixed position relative to the sensor support, a sensor mounted in a fixed position on the sensor support, and a lamp assembly removably mounted to the light source holder in a predetermined position defined by mating surfaces which engage each other and seat the lamp assembly in the predetermined position whenever the lamp assembly is installed in the holder.

Abstract: An optical sensor is provided utilizing a disposable flow cell with a cell body, an inlet tube and an outlet tube providing a flow passageway extending between the inlet tube and the outlet tube through the cell body. The sensor comprises a first housing component comprising an open front end and a back end to which a removable light source is mounted and a second housing component comprising an open front end and a back end to which a light detector for detecting light emitted by the removable light source is mounted. The first and second housing components are detachably connected to one another, the open front ends of first and second housing components being tightly engaged to provide a sensor housing which accommodates and encloses the disposable flow cell. The light source and the detector are positioned at opposing sides of the cell body, an optical pathway extending along an axis between the light source and the detector through the cell body perpendicular to the flow passageway.

Abstract: Light source for an inline sensor having one or more solid state UV emitters for emitting light at single wavelengths in the range of 240 to 400 nm. The light emitted by each of the emitters has a bandwidth on the order of 10-20 nm and is directed toward a measurement detector in the inline sensor. The UV emitters are enclosed in a housing which can be attached to the inline sensor, with a reference detector and a regulator for the UV emitters also within the housing, and an aperture through which the light passes from the emitters to the measurement detector.

Abstract: Self-aligning light source and detector assembly having a sensor support mounted in a predetermined, fixed position, a light source holder mounted in a predetermined, fixed position relative to the sensor support, a sensor mounted in a fixed position on the sensor support, and a lamp assembly removably mounted to the light source holder in a predetermined position defined by mating surfaces which engage each other and seat the lamp assembly in the predetermined position whenever the lamp assembly is installed in the holder.

Abstract: Manifold and probe assembly for use a bioprocessing vessel. The manifold has a chamber which communicates with the interior of the vessel and a plurality of ports which communicate with the chamber. Elongated sensing probes are threadedly connected to the ports with end portions of the probes extending into the chamber. Gaskets having generally annular bodies with conically inclined beveled faces are mounted on the end portions of the probes, with the beveled faces engaging conically inclined surfaces of seats in the ports and the gaskets being axially compressed and radially expanded into sealing engagement with the probes. The seating surfaces have inner and outer sections with different angles of inclination which produce greater radial expansion and tighter sealing with the probes.

Abstract: Inline flow cell for use in monitoring multiple parameters in a sanitary process line, comprising a body with opposing end walls, a flow passageway extending along an axis between the end walls, and a plurality of side walls disposed tangentially about the axis, inlet and outlet fittings communicating with the passageway at the ends of the body for connecting the flow cell in a sanitary process line with fluid in the line flowing through the passageway, and monitoring ports opening through more than two of the side walls for receiving sensors for monitoring multiple parameters in the fluid.

Abstract: Inline flow cell for use in monitoring multiple parameters in a sanitary process line, comprising a body with opposing end walls, a flow passageway extending along an axis between the end walls, and a plurality of side walls disposed tangentially about the axis, inlet and outlet fittings communicating with the passageway at the ends of the body for connecting the flow cell in a sanitary process line with fluid in the line flowing through the passageway, and monitoring ports opening through more than two of the side walls for receiving sensors for monitoring multiple parameters in the fluid.

Abstract: Photometric detector assembly which includes a housing, means for passing an optical beam along a path through the housing to a detector, a NIST traceable calibration filter enclosed within the housing, and a remotely operable actuator for moving the filter into and out of the beam path.

Abstract: Photometric detector assembly which includes a housing, means for passing an optical beam along a path through the housing to a detector, a NIST traceable calibration filter enclosed within the housing, and means operable externally of the housing for moving the filter into and out of the beam path between calibration and normal operating positions.

Abstract: Inline optical sensor having first and second optically transmissive windows positioned on opposite sides of a product stream. A light source is positioned outside the first window for directing light through the product stream, and the spacing between the windows is adjusted to control the length of an optical path through the product stream. A detector is positioned outside the second window for receiving light passing along the optical path, and a photometric calibration filter is removably installed between the second window and the detector for calibration of the system.