Abstract: A retention nut for securing a separator element is described herein. The retention nut includes a first portion of the retention nut that includes a threaded cavity to enable coupling of the retention nut to a structural member attached to the separator element, wherein the first portion of the retention nut comprises a means for providing a positive seal between the retention nut and the separator element, and a second portion of the retention nut that includes a feature that is couplable to a retention nut tool using a mechanical force such that a torque applied to the retention nut tool is sufficiently transmitted to the retention nut to one of: tighten the retention nut onto the structural element and loosen the retention nut from the structural element.

Abstract: A reciprocating compressor includes a piston slidably mounted within a compression chamber and defining a suction port. A valve selectively permits a flow of gas through the suction port and includes a sealing portion positioned over the suction port, an attachment portion mechanically coupled to a compression face of the piston, a support portion that extends away from the attachment portion along the radial direction such that the attachment portion is positioned between the sealing portion and the support portion, wherein the support portion defines a flattened end opposite the sealing portion along the radial direction such that the valve has a non-circular shape, and a connecting portion that mechanically couples the support portion to the sealing portion and permits the sealing portion to move between an open position and a closed position.

Abstract: A linear compressor or sealed system may include a casing, a piston, an driving coil, an inner back iron assembly, and a planar spring assembly. The casing may include a cylinder assembly defining a chamber along an axial direction. The piston may be slidably received within the chamber of the cylinder assembly. The inner back iron assembly may be positioned in the driving coil. The planar spring assembly may be mounted to the inner back iron assembly. The planar spring assembly may include a first planar spring, a second planar spring axially spaced apart from the first planar spring, and a polymer shim layer disposed between at least a portion of the first planar spring and the second planar spring.

Abstract: A reciprocating compressor includes a piston slidably mounted within a compression chamber and defining a suction port for receiving a flow of gas. A flex mount is mechanically coupled to the piston and has an inner surface that defines a suction cavity. A suction muffler is positioned at least partially within the suction cavity and includes an inlet tube extending along the axial direction within the suction cavity and defining an inlet passageway configured to receive the flow of gas and a plurality of chamber plates that extend along the radial direction from an outer surface of the inlet tube, the plurality of chamber plates and the flex mount defining a plurality of resonance chambers to reduce compressor noise.

Abstract: A reciprocating compressor includes a piston slidably mounted within a compression chamber and defining a suction port for receiving a flow of gas. A flex mount is mechanically coupled to the piston and has an inner surface that defines a suction cavity. A suction muffler is positioned at least partially within the suction cavity and includes an inlet tube extending along the axial direction within the suction cavity and defining an inlet passageway configured to receive the flow of gas and a plurality of chamber plates that extend along the radial direction from an outer surface of the inlet tube, the plurality of chamber plates and the flex mount defining a plurality of resonance chambers to reduce compressor noise.

Abstract: In certain example embodiments, the invention provides a method of generating an ex vivo cell-based system comprising dissociating an original tissue sample obtained from a subject into a single cell population; determining an in vivo phenotype of the tissue sample by conducting single-cell RNA analysis on a first portion of the single cells; establishing an ex vivo cell-based system from a second portion of the single cells; and culturing the ex vivo cell-based system in a medium or conditions selected to maintain the in vivo phenotype. In some embodiments, the original tissue sample is a tumor tissue sample, such as a pancreatic ductal adenocarcinoma (PDAC) tumor sample.

Abstract: A method for operating a variable capacity drive circuit of a compressor includes operating first and second four-quadrant switches in a first state in which the first four-quadrant switch is closed and the second four-quadrant switch is open such that a voltage seen by the motor is equal to an AC line voltage. The method also includes operating the first and second four-quadrant switches in a second state where the first four-quadrant switch is open and the second four-quadrant switch is closed such that the voltage seen by the motor is to zero. Further, the method includes providing a positive firing angle and a negative firing angle for defining when the first and second four-quadrant switches are operated in each of the first and second states. Moreover, the method also includes transitioning between the first and second states using the firing angles at a switching frequency determined by the AC line voltage frequency.

Abstract: A linear compressor includes a housing defining a sump for collecting a lubricant and a pump for circulating a flow of lubricant within the housing. A heat dissipation or heat exchange assembly includes a plate mounted on a lower portion of the housing to define one or more fluid passageways between the plate and the housing. Hot oil is collected from the working components of the linear compressor and is passed through the one or more fluid passageways to discharge heat through the housing before the oil is returned to the sump.

Abstract: A method for operating a variable capacity drive circuit of a compressor includes operating first and second four-quadrant switches in a first state in which the first four-quadrant switch is closed and the second four-quadrant switch is open such that a voltage seen by the motor is equal to an AC line voltage. The method also includes operating the first and second four-quadrant switches in a second state where the first four-quadrant switch is open and the second four-quadrant switch is closed such that the voltage seen by the motor is to zero. Further, the method includes providing a positive firing angle and a negative firing angle for defining when the first and second four-quadrant switches are operated in each of the first and second states. Moreover, the method also includes transitioning between the first and second states using the firing angles at a switching frequency determined by the AC line voltage frequency.

Abstract: A linear compressor or method of operation may provide for driving a motor of the linear compressor to a reference current and detecting a sampled current during driving the motor. The linear compressor or method may also provide for calculating a variance in current using the sampled current, determining the calculated variance exceeds a variance threshold, and restricting the reference current based on determining the calculated variance exceeds the variance threshold.

Abstract: A reciprocating compressor includes a piston slidably mounted within a compression chamber and defining a suction port. A valve selectively permits a flow of gas through the suction port and includes a sealing portion positioned over the suction port, an attachment portion mechanically coupled to a compression face of the piston, a support portion that extends away from the attachment portion along the radial direction such that the attachment portion is positioned between the sealing portion and the support portion, wherein the support portion defines a flattened end opposite the sealing portion along the radial direction such that the valve has a non-circular shape, and a connecting portion that mechanically couples the support portion to the sealing portion and permits the sealing portion to move between an open position and a closed position.

Abstract: A linear compressor includes a housing defining a sump for collecting a lubricant and a pump for circulating the lubricant within the housing. A heat dissipation assembly includes a distribution conduit that is fluidly coupled to a hot oil collection point and defines a plurality of discharge ports for distributing the lubricant along the housing and back into the sump. A flow restricting member may be positioned under or wrapped around the distribution conduit to restrict the flow of lubricant.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of EGLN1-dependent cancers. In particular, the instant disclosure provides for identification of a cancer as EGLN1-dependent, and selection and/or administration of an inhibitor of EGLN1 or VHL (Von Hippel-Lindau Tumor Suppressor) as a therapeutic agent for such a cancer and/or subject having or at risk of developing such a cancer.

Abstract: A linear compressor includes a housing defining a sump for collecting a lubricant and a pump for circulating a flow of lubricant within the housing. A heat dissipation or heat exchange assembly includes a plate mounted on a lower portion of the housing to define one or more fluid passageways between the plate and the housing. Hot oil is collected from the working components of the linear compressor and is passed through the one or more fluid passageways to discharge heat through the housing before the oil is returned to the sump.

Abstract: A linear compressor and methods of operation, for example, to control extension of the linear compressor, are provided herein. A method may include supplying a time varying voltage to a motor of the linear compressor, determining an uneven fatigue condition at the linear compressor, and applying a limiting force at the motor in a negative axial direction in response to the determining step.

Abstract: A sealed system, as provided herein, may include a linear compressor, a shell, and a condenser. The linear compressor may include a casing and a piston. The casing may extend along an axial direction from a first end portion to a second end portion. The casing may include a cylinder assembly defining a chamber proximal to the second end portion. The piston may be slidably received within the chamber of the cylinder assembly. The shell may define an internal volume enclosing the linear compressor and lubrication oil therein. The condenser may be in downstream fluid communication with the linear compressor to receive a compressed refrigerant therefrom.

Abstract: Provided herein are compounds useful for the treatment of various proliferative diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, and may be used in methods of treatment and/or prophylaxis of proliferative diseases, including cancer, and more specifically, pancreatic cancer.

Abstract: A linear compressor and methods of operation, for example, to control a setpoint and vary cooling capacity of the linear compressor, are provided herein. An appliance may include a linear compressor having a reciprocating piston movable in a negative axial direction toward a chamber and positive axial direction away from the chamber. The appliance may further include a motor operatively coupled to the reciprocating piston, the motor having a resting setpoint, an inverter configured to supply a variable frequency waveform to the motor, and a controller configured to control the variable frequency waveform. The controller may be configured to direct a positive DC voltage to the motor to shift the resting setpoint to increase a cooling capacity of the linear compressor.

Abstract: A linear compressor includes a housing defining a sump for collecting a lubricant and a suction inlet for receiving a flow of refrigerant into the housing. A pump circulates the lubricant within the housing, e.g., for lubricating a piston that is movable along the axial direction to compress the flow of refrigerant. A flex mount is coupled to the piston and defines a channel inlet for receiving the flow of refrigerant. A splash shield is positioned within the housing between the channel inlet and a pump inlet along the vertical direction, e.g., to prevent oil entrainment into the flow of refrigerant.

Abstract: A method for operating a linear compressor includes establishing a set of predictors, and establishing a model for an estimated head clearance of the linear compressor with the set of predictors. Coefficients of the model for the estimated head clearance of the linear compressor may also be established. The model for the estimated head clearance of the linear compressor may be used to calculate an estimated head clearance during operation of the linear compressor.