Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

Abstract: A system and method of hosting a plurality of trading algorithms on an exchange is provided. The method includes an exchange server that receives an algorithm for trading orders from a user and associates the algorithm with the user in a database. The exchange server receives a marked order having information for associating the marked order with the algorithm, selects the algorithm associated with the user, receives market data from a market data feed, and executes the marked order according to the selected algorithm and the market data. The system includes an exchange server, rule container and rule database configured to execute the above-noted method.

Abstract: The present invention relates to the use of a 2-cyanopyrimidine compound of the formula wherein R1, R2, R3 and X are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in tautomeric form, as an inhibitor of the activity of cathepsin S.

Abstract: The present invention relates to the use of a 2-cyanopyrimidine compound of the formula wherein R1, R2, R3 and X are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in tautomeric form, as an inhibitor of the activity of cathepsin S.

Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.

Abstract: The present invention relates to quinazolinones of formula (I) wherein R1 is hal; a); b); or c); X is N or CR8; R2 is hal; nitro; C1-C6alkylcarbonyl; C1-C6alkyl or C3-C6cycloalkyl; R3 is C1-C6alkyl; C1-C6alkoxy or amino; and wherein the further radicals have the meanings as defined in the specification, which compounds exhibit human vanilloid antagonistic activity; to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.

Abstract: A content delivery system, such as a Just in Time Training (JITT) system which allows the broadcast of multimedia messages to recipients or users. The JITT system identifies the multimedia capabilities as well as the capabilities of the service provider and recipient device for each user and uses this profile information to determine an appropriate messaging format to use to send the message to each user. User involvement is used to determine the functionality and content type delivery for each user mobile device. This profiling may be performed in any of a number of different ways, including smart echo, caller-ID initiated (CIDI) and SMS initiated (SMSI) profiling. In smart echo profiling, the user sends the JITT system a multimedia sample from the mobile device, and the JITT system then sends messages and content to the mobile devise using the same format.

Abstract: A system and method to create, present, and search “E-Interview” information. E-Interview information may comprise one or more of the following: a resume, a cover letter, a personality profile and interests, a perfect or ideal job description exercise, a character and values profile, a values statement, career goals, pre-answered job questions, other profiles or information selected by the applicant, employment questionnaires related to job function and values philosophy, goal-setting and job search tools, and video presentations. It also may comprise a picture of the applicant, voice-only interviews (in MP3 or other format), and statistics information that indicates how many times the applicant's profile has been viewed by potential employers. The information may be presented in a single website, as opposed to multiple websites or sources. A website containing multiple E-Interviews may be accessible by potential employers.

Abstract: The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.

Abstract: The present invention relates to the use of a chromone compound of the formula wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid antagonist.

Abstract: A battery charger with a self-contained power source which provides a current charging signal at or near the resonant frequency of the battery to be charged when no other power supply is readily available. A storage energy device, for example a battery, delivers a current charging signal modulated at or near the resonant frequency of a load, or stores energy from a source.

Abstract: A food container insert for holding tacos upright in a food container includes a plurality of pockets, oriented at a minor slope, to facilitate drainage of grease and juices from the taco filling away from the taco shell. Slits along the bottom of the pockets also facilitate the drainage of grease and juices from the taco filling away from the taco shell. The insert is suitable for both take-out food containers and chafing pans.

Abstract: A method and apparatus for eliminating artifacts in images formed using more than one image segment. A buffer region associated with two adjacent image segments is defined wherein the intensity levels of the pixels are attenuated. When image segments substantially overlap in the buffer region, the intensity in the buffer region substantially sums to full scale. The intensity of the pixels in the buffer region is preferably attenuated using a device to modulate the intensity of the source of radiation.

Abstract: The invention is a discrete patch suitable for use in the treatment of a viral lesion, which patch includes a backing layer and an adhesive layer, where the adhesive layer is substantially free of hydrocolloid particles, and the patch has a thickness ranging from about 10 microns to about 1,500 microns and is substantially free of topical anti-acne agents, and methods for treating viral lesions where a discrete patch of the invention is applied to a viral lesion and maintained in contact therewith for a time effective to substantially complete re-epithelialization of the lesion.

Abstract: The invention is a discrete patch suitable for use in the treatment of a viral lesion, which patch includes a backing layer and an adhesive layer, where the adhesive layer is substantially free of hydrocolloid particles, and the patch has a thickness ranging from about 10 microns to about 1,500 microns and is substantially free of topical anti-acne agents, and methods for treating viral lesions where a discrete patch of the invention is applied to a viral lesion and maintained in contact therewith for a time effective to substantially complete re-epithelialization of the lesion.

Abstract: The invention relates to sulfonyl amine derivatives of formula IA wherein R5A, X1, X2, R9 and R10 are as defined herein, which derivatives are useful as bradykinin B1 receptor antagonists.

Abstract: A method for monitoring the status of documents created by a large scale document production and management processes. The production and management process may be comprised of a plurality of different stages including: utilizing a print stream to generate the documents, printing documents on a printer in accordance with the print stream, and forming completed mail pieces on an inserter from the printed documents in accordance with mail piece creation data files. A monitoring system receives information regarding the status of individual documents within these production and management process stages. A user may then select one of the stages for closer inspection of the status of documents.

Abstract: A thick film current sensing resistor is provided having an input terminal for receiving an electrical current, and an output terminal for outputting the electrical current. A film of resistive material extends between the input and output terminals and is electrically coupled to the input and output terminals so that current flows through the film of resistive material. A pair of sensing terminals are provided to sense a voltage potential across the film of resistive material. The sensed voltage provides an indication of the current. An gap is formed in the film of resistive material between the input and output terminals and the sensing terminals. The length of the gap defines a voltage sensing point of the sensing terminals.

Abstract: A constant gain, constant phase RF power block, e.g., for use in a RF amplifier apparatus. In a preferred embodiment, the power block includes a DC to DC power supply circuit co-located with an RF power transistor device on a common heat sink. The power supply circuit has as an input a varying DC voltage and as outputs a constant supply voltage and a constant bias voltage. The power device has as inputs the constant supply voltage and the constant bias voltage, and further configured to receive and amplify an RF signal. The power supply circuit preferably includes a first laser trimmable resistor for setting the constant supply voltage and a second laser trimmable resistor for setting the bias voltage. In this manner, the constant supply and bias voltages may be easily tuned to a desired level during assembly of the power block device. The input and amplified RF signals are each matched to a relatively high impedance, e.g., approximately fifty ohms.