Abstract: A series of N-substituted 9-azabicyclo[3.3.1]nonan-3?-yl phenylcarbamate analogs are disclosed, as well as methods of their preparation. Their affinities for sigma (?1 and ?2) receptors are described. Two new compounds, N-(9-(4-aminobutyl)-9-azabicyclo[3.3.1]nonan-3?-yl)-N?-(2-methoxy-5-methylphenyl)carbamate and N-(9-(6-aminohexyl)-9-azabicyclo[3.3.1]nonan-3?-yl)-N?-(2-methoxy-5-methylphenyl)carbamate, are shown to have a high affinity and selectivity for ?2 versus ?1 receptors. Among the disclosed compounds are biotinylated and fluorescent analogs. These compounds can serve as probes to the ?2 receptor. In addition, some disclosed compounds can induce apoptotic cell death by both caspase-dependent and caspase-independent mechanisms, and are effective for treatment of tumors. The compounds can be used as chemotherapeutics or chemosensitizers in the treatment of a wide variety of solid tumors.

Abstract: A new and improved control system architecture using a combination of standard function blocks and new flexible function blocks eliminates the need for expensive and difficult to maintain custom control software and special I/O gateways for discrete/hybrid/batch and PLC applications. The end user builds application-specific flexible function blocks by configuring the number and type of inputs and outputs, and the block algorithm. Flexible function blocks and gateway flexible function block interconnect and interoperate with each other and with standard function blocks in a distributed control architecture.

Abstract: Methods, systems, and machine-readable mediums are disclosed for creating game elements using location information. In one embodiment, at least one-machine readable medium has instructions stored thereon, which, when executed by a machine cause the machine to implement a game, to obtain information about a location of the machine, and to abstract the information into an element of the game.

Abstract: A unified web portal for potential travelers to find localized information specific to a particular geographic area and assist in direct booking of an itinerary with the selected establishments. The website is implemented on a web-enabled server maintained by a Manager, and includes a home page containing introductory travel information on the localized area and URL links to Business, Tourism, Lodging and Restaurants pages allowing the Client to specify travel categories for submission to a search engine to compile “best match” third-party URL links based on the categories, as we well as a Contact Us page displaying Manager contact info, an Upcoming Events page display a list of upcoming local events in the area.

Abstract: A new and improved control system architecture using a combination of standard function blocks and new flexible function blocks eliminates the need for expensive and difficult to maintain custom control software and special I/O gateways for discrete/hybrid/batch and PLC applications. The end user builds application-specific flexible function blocks by configuring the number and type of inputs and outputs, and the block algorithm. Flexible function blocks and gateway flexible function block interconnect and interoperate with each other and with standard function blocks in a distributed control architecture.

Abstract: A distributed control system architecture (HSE) provides an open, interoperable solution optimized for integration of distributed control systems and other control devices in a high performance backbone, provides an open, interoperable solution that provides system time synchronization suitable for distributed control applications operable over a high performance backbone, and provides an open, interoperable solution that provides a fault tolerant high performance backbone as well as fault tolerant devices that are connected to the backbone. The distributed control system architecture comprises a High speed Ethernet Field Device Access (HSE FDA) Agent, which maps services of a distributed control system, e.g., a fieldbus System, to and from a standard, commercial off-the-shelf (COTS) Ethernet/Internet component.

Abstract: A distributed control system architecture (HSE) provides an open, interoperable solution optimized for integration of distributed control systems and other control devices in a high performance backbone, provides an open, interoperable solution that provides system time synchronization suitable for distributed control applications operable over a high performance backbone, and provides an open, interoperable solution that provides a fault tolerant high performance backbone as well as fault tolerant devices that are connected to the backbone. The distributed control system architecture comprises a High speed Ethernet Field Device Access (HSE FDA) Agent, which maps services of a distributed control system, e.g., a fieldbus System, to and from a standard, commercial off-the-shelf (COTS) Ethernet/Internet component.

Abstract: A catheter and guide wire exchange system including a catheter that has a guide wire lumen with a guide way extending along a length of the proximal shaft. A guide member is slidably disposed about the proximal shaft for directing a guide wire into or out of the guide way and the guide wire lumen. A transition section joins the bilumen proximal shaft to a coaxial distal shaft.

Abstract: A catheter and guide wire exchange system including a catheter that has a guide wire lumen with a guide way extending along a length of the proximal shaft. A guide member is slidably disposed about the proximal shaft for directing a guide wire into or out of the guide way and the guide wire lumen. A transition section joins the bitumen proximal shaft to a coaxial distal shaft.

Abstract: N-Phenylpyrazole derivatives of the formula: wherein R1 represents optionally halogenated alkyl; R2 represents halogen, cyano, nitro, cycloalkyl, alkenyl, thiocyanato, optionally alkyl substituted sulphamoyl, optionally alkyl substituted carbamoyl, alkoxycarbonyl, alkanoyl or optionally halogenated alkyl; and R3 represents a hydrogen atom or a group N″R′″ or a variety of other groupings. These compounds possess arthropodicidal, plant nematocidal, anthelmintic and anti-protozoal properties; their preparation, compositions containing them and their use are described.

Abstract: Compound of the formula are useful as intermediates to new 4-benzoylisoxazoles.

Abstract: The invention relates to 1-arylpyrazole-3-thiocarboxamide derivatives of formula (I): 1

Abstract: The invention relates to intermediates to herbicidal compounds of formulae (Ia), (Ib) or (Ic): ##STR1##

Abstract: A process for preparing a compound of the formula ##STR1## wherein R is C.sub.1 -C.sub.18 alkyl by reacting a compound of the formulaRO.sub.2 C--CH.sub.2 CN (II)with a cyanide salt and formaldehyde or source thereof. Compounds of formula (I) are useful intermediates to pesticidally active compounds.

Abstract: Compounds of the formula are useful as intermediates to new herbicidal 4-benzoylisoxazoles.

Abstract: A method and apparatus for providing water from a lake, pond, or other body of water, relatively silt and sediment free. A water inlet is positioned off the bottom of the body of water and is adjustably supported from the bottom of the body of water. The inlet is maintained above the silt and sediment layer at the bottom of the body of water and below the surface layer of the body of water.

Abstract: The invention relates to intermediates to herbicidal compounds of formulae (Ia), (Ib) or (Ic): ##STR1##

Abstract: An information delivery system including a head end broadcasting a data stream of media objects, the head end being coupled to a broadcast television interface and at least one information service provider and including an encoder for encoding information in the media object is disclosed. The system may deliver and implement a programming guide delineating programming information available on the information delivery system in one or more media objects in the data stream in an encoded fashion by the encoder. A user terminal is coupled to the head-end and receives the media objects. The user terminal has an output and includes a decoder for the media objects. Also provided in one aspect is a user interface, at least partially stored in the user-terminal, which selects a user-defined subset of media objects for provision to the output of the user terminal. Further, an information navigation system for an information delivery system is provided.

Abstract: Compounds of the formula ##STR1## are useful as intermediates to new herbicidal 4-benzoylisoxazoles.

Abstract: N-Phenylpyrazole derivatives of the formula: ##STR1## wherein R.sup.1 represents cyano, nitro, halogen, acetyl or formyl; R.sup.2 represents R.sup.5 SO.sub.2, R.sup.5 SO or R.sup.5 S in which R.sup.5 is optionally halogen substituted alkyl, alkenyl or alkynyl;R.sup.3 represents a hydrogen atom or a group NR.sup.6 R.sup.7 wherein R.sup.6 and R.sup.7 each represent hydrogen, alkyl, alkenylalkyl, alkynylalkyl, formyl, optionally halogen substituted alkanoyl, optionally halogen substituted alkoxycarbonyl, or alkoxymethyleneamino, halogen, or R.sup.6 and R.sup.7 together form a cyclic imide and R.sup.4 represents a substituted phenyl group possess arthropodicidal, plant nematocidal, anthelmintic and anti-protozoal properties; their preparation, compositions containing them and their use are described.