Abstract: The present invention relates compositions, methods and kits for characterizing the type of and screening for the existence or predisposition for small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). The invention also relates to a method of treating a mammalian subject having SCCOHT or a predisposition for SCCOHT.

Abstract: Methods are provided for treating lung cancer, and more particularly for treating pulmonary adenocarcinoma in a canine subject. The method may comprise assaying a biological sample from the canine subject, such as a tumor sample or a plasma sample, for a mutation in the HER2 gene. The mutation may include HER2 V659E, HER2 A664T, or HER2 K676E. If one or more of the mutations is present in the biological sample, the methods further include treating the canine subject by administering a therapeutically effective amount of an inhibitor of HER2. For example, a HER2 V659E may indicate increase sensitivity to a HER2 inhibitor. The HER2 inhibitor may include a small molecule HER2 inhibitor, such as trastuzumab, neratinib, lapatinib, erlotinib, and pertuzumab.

Abstract: The present disclosure provides systems and methods for the benefit of surgical procedures in such austere locations. As described herein, the technology is applicable anywhere in the world where access to medical care is limited or not available but necessary, especially more than one hour away by transport. These applications include space, military field medicine, recreational wilderness medicine, sites of disasters (e.g., earthquakes, tsunamis, building collapses, etc.), healthcare in rural or underdeveloped locations, and hospitals or clinics with resource shortages or limitations.

Abstract: A sensor rod assembly includes a master stick and an extension stick, where the master stick and the at least one extension stick are couplable together via at least one of a physical coupling, an electrical coupling, or a communicative coupling. The sensor rod assembly includes a controller with one or more processors, where the one or more processors are communicatively coupled to at least one set of detection circuitry and a user interface, where the one or more processors are configured to execute a set of program instructions configured to cause the one or more processors to receive one or more detection signals from at least one of the master stick or the extension stick and configured to cause the one or more processors to determine an elevation of a laser light based on the received one or more detection signals.

Abstract: Methods are provided for treating lung cancer, and more particularly for treating pulmonary adenocarcinoma in a canine subject. The method may comprise assaying a biological sample from the canine subject, such as a tumor sample or a plasma sample, for a mutation in the HER2 gene. The mutation may include HER2 V659E, HER2 A664T, or HER2 K676E. If one or more of the mutations is present in the biological sample, the methods further include treating the canine subject by administering a therapeutically effective amount of an inhibitor of HER2. For example, a HER2 V659E may indicate increase sensitivity to a HER2 inhibitor. The HER2 inhibitor may include a small molecule HER2 inhibitor, such as trastuzumab, neratinib, lapatinib, erlotinib, and pertuzumab.

Abstract: A sensor rod assembly includes a master stick and an extension stick, where the master stick and the at least one extension stick are couplable together via at least one of a physical coupling, an electrical coupling, or a communicative coupling. The sensor rod assembly includes a controller with one or more processors, where the one or more processors are communicatively coupled to at least one set of detection circuitry and a user interface, where the one or more processors are configured to execute a set of program instructions configured to cause the one or more processors to receive one or more detection signals from at least one of the master stick or the extension stick and configured to cause the one or more processors to determine an elevation of a laser light based on the received one or more detection signals.

Abstract: The present invention relates compositions, methods and kits for characterizing the type of and screening for the existence or predisposition for small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). The invention also relates to a method of treating a mammalian subject having SCCOHT or a predisposition for SCCOHT.

Abstract: An enteral feeding device, includes a system for delivering liquid nutrients to an enteral feeding tube. The device includes: (a) a container, having first, second and third openings; (b) a tip configured to be coupled to the container, the tip having an opening in fluid communication with the first opening of the container, the second opening of the container configured such that nutrient can be delivered to the second opening and the third opening configured to receive nutrient or to allow gas expelled from the patient (e.g., through burping) to flow there through.

Abstract: An enteral feeding device, includes a system for delivering liquid nutrients to an enteral feeding tube. The device includes: (a) a container, having first, second and third openings; (b) a tip configured to be coupled to the container, the tip having an opening in fluid communication with the first opening of the container, the second opening of the container configured such that nutrient can be delivered to the second opening and the third opening configured to receive nutrient or to allow gas expelled from the patient (e.g., through burping) to flow there through.

Abstract: This application relates to various methods and apparatus for rapidly obtaining accurate formation property data from a drilled earthen borehole. Quickly obtaining accurate formation property data, including formation fluid pressure, is vital to beneficially describing the various formations being intersected. For example, methods are disclosed for collecting numerous property values with a minimum of downhole tools, correcting and calibrating downhole measurements and sensors, and developing complete formation predictors and models by acquiring a diverse set of direct formation measurements, such as formation fluid pressure and temperature. Also disclosed are various methods of using of accurately and quickly obtained formation property data.

Abstract: This application relates to various methods and apparatus for rapidly obtaining accurate formation property data from a drilled earthen borehole. Once obtained, the formation property data, including formation fluid pressure, may be corrected, calibrated and supplemented using various other data and techniques disclosed herein. Furthermore, the formation property data may be used for numerous other purposes. For example, the data may be used to correct or supplement other information gathered from the borehole; it may be used to supplement formation images or models; or, it may be used to adjust a drilling or producing parameter. Various other uses of accurately and quickly obtained formation property data are also disclosed.

Abstract: A tupelo tree named ‘WFH1’, a tree distinguished by its narrow columnar growth habit.