Patents by Inventor William Henry Holms

William Henry Holms has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
    Patent number: 6235506
    Abstract: Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: May 22, 2001
    Assignee: SmithKline Beecham, p.l.c.
    Inventors: Brian Peter Valentine, Paul Alan Jeffkins, William Henry Holms, David Michael Mousdale
  • Process to increase the production of clavam antibiotics
    Patent number: 6171814
    Abstract: A process for increasing the amount of clavam produced by an organism having both a clavam pathway or a portion thereof and a cephalosporin pathway or a portion thereof by interfering with the conversion of L-lysine to L-&agr;-aminoadipic acid in the cephalosporin pathway. Plasmids containing a defective LAT (lysine amino transferase) gene and organisms containing such plasmids are also provided.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: January 9, 2001
    Assignees: SmithKline Beecham p.l.c., The Governors of the University of Alberta
    Inventors: William Henry Holms, Ashish Sudhakar Paradkar, Roy Henry Mosher
  • Process for the fermentative preparation of clavam derivatives whereby the levels of ammonia and urea in the fermentation medium are kept low
    Patent number: 5985624
    Abstract: Improved methods for the preparation of clavams by fermentation of a clavam-producing organism in a suitable medium wherein the ammonium levels are kept low so as to avoid repression of enzymes, particularly urease, are disclosed.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: November 16, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Brian Peter Valentine, Paul Alan Jeffkins, William Henry Holms, David Michael Mousdale
  • Process for producing clavulanic acid
    Patent number: 5869299
    Abstract: A process for preparing clavulanic acid and other clavam derivatives using an enzyme system from Streptomyces, particularly S. Clavuligerus.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: February 9, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Keith Howard Baggaley, Neville Hubert Nicholson, Stephen William Elson, Jeffrey Edwards, Alison Jane Earl, William Henry Holms, David Michael Mousdale, Jack Edward Baldwin, Christopher Schofield