Patents by Inventor William Henry Koster

William Henry Koster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-.alpha. substituted imino 7-.beta. substituted thio cephalosporin derivatives
    Patent number: 4071682
    Abstract: An improved, versatile method for producing 7-cephalosporin derivatives having a 7-alkylthio or 7-arylthio group which comprises treating a 7-substituted imino halide, imino ether or iminothio ether of 7-aminocephalosporanic acid, 7-amino-3-desacetoxycephalosporanic acid and the like with a thiolating agent in the presence of a base, to obtain the thio derivative. These products are particularly useful for conversion to 7.alpha.-alkylthio or 7.alpha.-arylthio-7-acylamino intermediates which are converted to lower alkoxy cephalosporin derivatives useful as antibacterial agents.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: January 31, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph Edward Dolfini, William A. Slusarchyk, William Henry Koster
  • 7-(.alpha.-Cyanomethylthio)acetamido-3-cephem carboxylates
    Patent number: 3985746
    Abstract: New 7-(.alpha.-cyanomethylthio)acetamido-3-cephem carboxylates which have the formula ##EQU1## have antimicrobial activity.
    Type: Grant
    Filed: March 25, 1975
    Date of Patent: October 12, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William Henry Koster, William A. Slusarchyk, Jack Bernstein
  • Production of 2-(thio substituted)cephalosporin sulfoxides and 2-(thio substituted)cephalosporins
    Patent number: 3968109
    Abstract: A new method of producing 2-(thio substituted) cephalosporin derivatives comprises treating a cephem sulfoxide with an electrophilic sulfur reagent in the presence of a strong base. The cephem sulfoxides produced by this step are useful as intermediates, which by reduction of the sulfoxide group, yield 2-(thio substituted) cephalosporins having useful antimicrobial activity.
    Type: Grant
    Filed: November 23, 1973
    Date of Patent: July 6, 1976
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William Henry Koster, Joseph Edward Dolfini