Abstract: The invention provides a composition comprising a colloidal particle comprising about 0.5 to 20 mole percent of an amphipathic lipid derivatized with a biocompatible hydrophilic polymer for use in medicine, wherein said composition does not contain any pharmaceutically active agent.

Abstract: The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for controlling a power level of wireless power transfer. Certain aspects provide a wireless power receiver. The wireless power receiver includes an antenna and a rectifier. The rectifier includes a first diode and a second diode. The wireless power receiver further includes a resistor in parallel with the first diode. A first terminal of the resistor is coupled to a first terminal of the first diode. A second terminal of the resistor is coupled to a second terminal of the first diode.

Abstract: A fiber optic connector inspection display system including: a input unit which receives fiber end-face images; a display mode election unit which allows a user to select at least one of an image capture mode or an image review mode; a capturing unit which captures the fiber end-face images; a storing unit which stores the captured images as a first still image and a second still image; a display unit which displays the received fiber end-face images from the input unit or the stored first and second still images, and a control unit which stores each of the first and second still images with a user defined identification label, and the control unit may further label the each of the first and second still images with a preset image pair mode label if the user selects a preset image pair mode.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for providing knowledge panels with search results. In one aspect, a method includes obtaining search results that are responsive to a received query. A factual entity referenced by the query is identified. Content is identified for display in a knowledge panel for the factual entity. The content includes at least one content item obtained from a first resource and at least one second content item obtained from a second resource different than the first resource. Data is provided that causes the identified search results and the knowledge panel to be presented on a search results page. The knowledge panel presents the identified content in a knowledge panel area that is along side at least a portion of the search results.

Abstract: The present invention relates to a formulation comprising blends of formulations (or colloidal dispersions) and its topical application. The formulation comprises at least two different types of colloidal dispersion comprising deformable colloidal particles, wherein the deformable colloidal particles comprise a non-ionic surfactant and/or a phospholipid. The deformable colloidal particles of the invention may comprise an agent of interest (AOI) or may be free of an AOI. The formulation may comprise an AOI that is not associated with the deformable colloidal particles. The present invention also includes kits comprising the formulation of the present invention and the use of the formulation in medicine, skin care and cosmetics.

Abstract: A vacuum cleaner including a cyclonic separating unit that includes a cyclonic separator having a separator axis and an end wall which is openable for the removal of dirt from the cyclonic separator, a screen disposed within the cyclonic separator such that it extends in the longitudinal direction of the cyclonic separator, wherein the cyclonic separator is movable relative to the screen between a first position and a second position in the longitudinal direction of the cyclonic separator; a catch arranged to secure the openable end wall in a closed position; and an actuator which is actuated to release the catch when the cyclonic separator is moved into the second position. In an alternative embodiment, there is provided a vacuum cleaner apparatus in which the actuator is enabled for subsequent release of the catch when the cyclonic separator is moved into the second position.

Abstract: Disclosed is a method and apparatus for mitigating temperature spikes and dissipating heat. The apparatus for mitigating temperature spikes and dissipating heat comprises one or more heatsinks, one or more sensors, one or more phase change materials and one or more processors coupled to the one or more sensors. The one or more processors may be configured to obtain one or more sensor measurements and may be configured to determine whether to store heat or dissipate heat based on the one or more sensor measurements. In response to a determination to dissipate heat, the one or more processors may be configured to dissipate heat from the one or more processors, the one or more phase change materials or both using the one or more heatsinks. Furthermore, in response to a determination to store heat, store heat from the one or more processors using the one or more phase change materials.

Abstract: A polycrystalline diamond compact (PDC), which is attached or bonded to a substrate to form a cutter for a drill bit, is comprised of sintered polycrystalline diamond interspersed with a seed material which has a hexagonal close packed (HCP) crystalline structure. A region of the sintered polycrystalline diamond structure, near one or more of its working surfaces, which has been seeded with an HCP seed material prior to sintering, is leached to remove catalyst. Selectively seeding portions or regions of a sintered polycrystalline diamond structure permits differing leach rates to form leached regions with differing distances or depths and geometries.

Abstract: Certain aspects of the present disclosure relate to methods and apparatus for detecting, by a wireless power transmitter, an over voltage protection at a wireless power receiver. Certain aspects of the present disclosure provide a wireless power transmitter. The wireless power transmitter includes a resonator configured to generate a wireless field for wirelessly transferring power to a wireless power receiver. The wireless power transmitter further includes an impedance detector configured to measure an impedance of the resonator. The wireless power transmitter further includes a controller configured to detect operation of an over voltage protection mode of the wireless power receiver based on a frequency of change in impedance as measured by the impedance detector.

Abstract: Certain aspects of the present disclosure relate to systems and methods for using electrostatic deflection of tissue to generate ultrasound power signals, such as for powering medical implants. Certain aspects of the present disclosure provide a system for generating ultrasonic pressure waves. The system includes an electrode configured to be positioned near a tissue. The system further includes an AC signal generator coupled to the electrode, wherein the AC signal generator is configured to apply an AC signal to the electrode causing the tissue to vibrate to generate ultrasonic pressure waves directed to an ultrasonic power receiver implanted under the tissue.

Abstract: Charging a medical implant is performed through the use of an external thermionic implant charging unit placed on the skin of the patient, proximate to the location where a subcutaneous thermionic implant is located. A voltage input can cause the thermionic implant charging unit to enter a warming or cooling phase in which the voltage creates a temperature gradient across a thermoelectric heat pump of the charging unit, causing the charging unit to respectively warm or cool the patient's skin. The thermionic implant can similarly have a thermoelectric heat pump, and the warming or cooling of the skin caused by the charging unit can create a temperature gradient across the thermoelectric heat pump of the thermionic implant, causing its thermoelectric heat pump to create a voltage. This voltage can be used to charge a battery of (and/or directly power) the thermionic implant.

Abstract: In one aspect, a method related to data management. In addition, other method, system, and program product aspects are described in the claims, drawings, and/or text forming a part of the present application.

Abstract: A system and a method for creating a stable and reproducible interface of an optical sensor system for measuring blood glucose levels in biological tissue include a dual wedge prism sensor attached to a disposable optic that comprises a focusing lens and an optical window. The disposable optic adheres to the skin to allow a patient to take multiple readings or scans at the same location. The disposable optic includes a Petzval surface placed flush against the skin to maintain the focal point of the optical beam on the surface of the skin. Additionally, the integrity of the sensor signal is maximized by varying the rotation rates of the dual wedge prisms over time in relation to the depth scan rate of the sensor. Optimally, a medium may be injected between the disposable and the skin to match the respective refractive indices and optimize the signal collection of the sensor.

Abstract: A system for detecting and characterizing an object proximate to a wireless power transmitting unit includes a transmit circuit having a transmit antenna, the transmit circuit configured to transmit at least one signal having a frequency related to a fundamental power transmit frequency, the transmit circuit configured to measure a response of the transmit antenna, and a controller circuit configured to characterize the object based on the response of the transmit antenna.

Abstract: Certain aspects of the present disclosure are generally directed to apparatus and techniques for protecting electronic devices that may be prone to damage by wireless charging fields. For example, the apparatus may include a wireless charging circuit configured to selectively generate a wireless charging field and an impedance detection circuit coupled to the wireless charging circuit and configured to detect an impedance change corresponding to the wireless charging field. In this case, a proximity detection circuit may selectively detect proximity of one or more electronic devices that are prone to damage by the wireless charging circuit. In some aspects, detecting the proximity of the one or more electronic devices is activated based on detecting the impedance change, and wherein generating the wireless charging field comprises reducing a transmit power of the wireless charging field based on detecting the impedance change.

Abstract: Embodiments of devices to protect edges of objects are described. The objects can include musical instruments and the devices can be coupled to an edge of the musical instruments. One or more of the devices can be disposed around one or more portions of an edge of a musical instrument to minimize or prevent contact between the edge of the musical instrument and surfaces or other objects that may contact the musical instrument.

Abstract: Example systems and methods relating to dynamic requirement variation for asset acquisition in an online game are presented. In an example online game for multiple players, a plurality of parameters employed to identify players who qualify for a reward provided by the online game are accessed continually. A current acquisition requirement for the reward based on the plurality of parameters is updated continually. The reward is provided to at least one of the players responsive to satisfaction of the current acquisition requirement by the at least one of the players.

Abstract: In an embodiment, a vehicle controller determines a predicted driving performance level of a vehicle driving control entity (VDCE) while the vehicle is controlled by a different VDCE. Driving control is transitioned to the VDCE, after which an actual driving performance level of the VDCE is monitored. The vehicle controller determines whether to transition driving control away from the VDCE based on the actual driving performance level. In another embodiment, after transition driving control to a VDCE, a period of heightened scrutiny used to evaluate the actual driving performance level of the VDCE specifically after the transition.

Abstract: A system and method for charging a chargeable device is provided. The system can include a wireless charger including a wireless power transmitter d configured to generate a wireless charging field in at least one charging region. The wireless charger further includes a transceiver configured to communicate with the chargeable device. The wireless charger further includes a controller configured to facilitate avoidance of cross connection of the chargeable device with the wireless charger and at least one other wireless charger by initiating a disconnection of a communication link between the wireless charger and the chargeable device based at least in part on a comparison of a detected power level of the wireless charger to a predetermined level indicative of saturation.