Abstract: The air hose retention device includes a first connector pivotally engaged to a top and an outer spool having a receiving area. A second side of a housing is rotatably engaged to a first side. A cable is wound on the outer spool. A spring is disposed in the receiving area. Pulling of the cable causes rotation of the second side in a first direction and the coiling of the spring. Movement of the cable towards the housing uncoils the spring winding the cable about the outer spool and rotating the second side in a second direction. The cable has a releasable connector which is engaged to a connector hose of a trailer. The air hose retention device may be easily disconnected from both a cab and a connector hose for storage or transportation in a cab of a truck during periods of nonuse.

Abstract: The present invention relates enhanced targeting of drug delivery vehicles to vascular endothelial cells

Abstract: The invention contemplates a composition containing a multispecific ligand containing at least a first ligand binding moiety and a second ligand binding moiety. The first ligand binding moiety specifically binds with a pre-selected first affinity to at least a first ligand. The first ligand has a first biodistribution. The second ligand binding moiety specifically binds with a pre-selected affinity to at least a second ligand. The second ligand has a second biodistribution. The affinity of first and second ligand binding moieties are selected to bias the biodistribution of the multispecific ligand in favor of a selected location of one or both of the ligands.

Abstract: A turbine blade includes an airfoil, platform, shank, and dovetail. The shank includes opposite forward and aft faces corresponding with leading and trailing edges of the airfoil, and opposite first and second sides corresponding with pressure and suction sides of the airfoil. The shank further includes lugs extending outwardly from the two sides, with a first lug having an inverted skirt extending outwardly toward the platform to join the shank aft face. The skirt cooperates with a seal body when mounted in the engine for reducing inter-blade leakage.

Abstract: The invention contemplates a composition containing a multispecific ligand containing at least a first ligand binding moiety and a second ligand binding moiety. The first ligand binding moiety specifically binds with a pre-selected first affinity to at least a first ligand. The first ligand has a first biodistribution. The second ligand binding moiety specifically binds with a pre-selected affinity to at least a second ligand. The second ligand has a second biodistribution. The affinities of first and second ligand binding moieties are selected to bias the biodistribution of the multispecific ligand in favour of a selected location of one or both of the ligands.

Abstract: The invention contemplates a composition containing a multispecific ligand containing at least a first ligand binding moiety and a second ligand binding moiety. The first ligand binding moiety specifically binds with a pre-selected first affinity to at least a first ligand. The first ligand has a first biodistribution. The second ligand binding moiety specifically binds with a pre-selected affinity to at least a second ligand. The second ligand has a second biodistribution. The affinity of first and second ligand binding moieties arc selected to bias the biodistribution of the multispecific ligand in favour of a selected location of one or both of the ligands.

Abstract: The invention contemplates a composition containing a multispecific ligand containing at least a first ligand binding moiety and a second ligand binding moiety. The first ligand binding moiety specifically binds with a pre-selected first affinity to at least a first ligand. The first ligand has a first biodistribution. The second ligand binding moiety specifically binds with a pre-selected affinity to at least a second ligand. The second ligand has a second biodistribution. The affinity of first and second ligand binding moieties are selected to bias the biodistribution of the multispecific ligand in favour of a selected location of one or both of the ligands.