Patents by Inventor William Howson

William Howson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tachykinin antagonists
    Patent number: 5767088
    Abstract: The small compounds of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK.sub.3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, addiction disorders, inflammatory diseases, gastrointestinal disorders, vascular disorders, and neuropathological disorders.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: June 16, 1998
    Assignee: Warner-Lambert Company
    Inventors: David Christopher Horwell, William Howson, Martyn Clive Pritchard, Jennifer Raphy
  • Tachykinin antagonists
    Patent number: 5716979
    Abstract: The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.The compounds are expected to be especially useful in asthma and rheumatoid arthritis.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: February 10, 1998
    Assignee: Warner-Lambert Company
    Inventors: David Christopher Horwell, William Howson, Martyn Clive Pritchard, Edward Roberts, David Charles Rees
  • Tachykinin (NK1) receptor antagonists
    Patent number: 5610176
    Abstract: The invention concerns tachykinin antagonists. The compounds are alcohols, amines and prodrugs of nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.The compounds are expected to be especially useful in asthma, multiple sclerosis, rheumatoid arthritis, the management of pain, migraine, and antiemetic agents.
    Type: Grant
    Filed: September 7, 1995
    Date of Patent: March 11, 1997
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, William Howson, Martyn C. Pritchard
  • Tachykinin antagonists
    Patent number: 5610145
    Abstract: The small compounds of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK.sub.3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, addiction disorders, inflammatory diseases, gastrointestinal disorders, vascular disorders, and neuropathological disorders.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: March 11, 1997
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, William Howson, Martyn C. Pritchard, Jennifer Raphy
  • Tachykinin antagonists
    Patent number: 5594022
    Abstract: The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.The compounds are expected to be especially useful in asthma and rheumatoid arthritis.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: January 14, 1997
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, William Howson, Martyn C. Pritchard, Edward Roberts, David C. Rees
  • Tachykinin (NK.sub.2) antagonists
    Patent number: 5554644
    Abstract: The compounds of the instant invention are ligands for the NK.sub.2 receptor. The compounds are modified at the C-terminus to provide various amide isostere derivatives expected to be useful in treating obesity, anxiety, gastrointestinal ulcers, pain, stroke, and inflammation. Pharmaceutical compositions and methods of using the compounds are also included.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: September 10, 1996
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, William Howson, Simon Osborne
  • Method of stimulating histamine H.sub.3 -receptors
    Patent number: 5047418
    Abstract: A pharmaceutical composition is described which comprises a pharmaceutically acceptable carrier and a compound of the formula (1): ##STR1## or a pharmaceutically acceptable salt thereof wherein X is CH.sub.2 or S, in an amount sufficient to stimulate selectively histamine H.sub.3 -receptors.
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: September 10, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William Howson