Patents by Inventor William J. Adams, Jr.

William J. Adams, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and method for high-throughput testing
    Patent number: 10232336
    Abstract: The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: March 19, 2019
    Assignees: The Charles Stark Draper Laboratory, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, Jr., Mitchell Hansberry, Stephen Bellio
  • SYSTEMS AND METHOD FOR HIGH-THROUGHPUT TESTING
    Publication number: 20150126411
    Abstract: The systems and methods described herein relate to a high-throughput flow apparatus. The apparatus is used with an array of wells, and is configured to impart a predetermined shear stress on cells cultured within each of the wells of the array of wells. The apparatus includes a plurality of mechanical tips. The plurality of mechanical tips each includes a head with a hemispheroid shape. The apparatus also includes a motor associated with at least one of plurality of mechanical tips. The motor is configured to drive the plurality of mechanical tips to impart the shear stress pattern in each of the wells.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 7, 2015
    Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, JR., Mitchell Hansberry, Stephen Bellio
  • High-throughput biological screening
    Patent number: 9006149
    Abstract: A high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. A separate sleeve may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable within its corresponding sleeve. Alternatively, a separate post may be associated with each tip for maintaining a predetermined distance between the tip and a floor of the tip's corresponding well, with each tip being rotatable about its corresponding post.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: April 14, 2015
    Assignees: The Charles Stark Draper Laboratory, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adams, Jr.
  • High-Throughput Biological Screening
    Publication number: 20100323916
    Abstract: In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern.
    Type: Application
    Filed: January 14, 2010
    Publication date: December 23, 2010
    Inventors: Guillermo Garcia-Cardena, Peter Mack, Jeffrey T. Borenstein, Ahmad S. Khalil, Eli J. Weinberg, Jason O. Fiering, Ernest S. Kim, William J. Adam, JR.