Patents by Inventor William J. Benett
William J. Benett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11975321Abstract: A multi-channel optical detection system includes a base unit adapted to receive a multi-chamber assay cartridge having a plurality of reaction chambers loaded with a sample and an optical detection reagent, and an optical detection unit having a multi-channel optical block having a plurality of detection channels each with an associated light source, and an optic sensor. The optical detection unit is connectable to the base unit so that interrogation ports of the detection channels are optically aligned with optically transparent windows of the reaction chambers of a loaded cartridge, so that upon initialization, light sources are activated to interrogate reaction products in the reaction chambers and detect the optical responses therefrom.Type: GrantFiled: March 27, 2019Date of Patent: May 7, 2024Assignee: Lawrence Livermore National Security, LLCInventors: Lawrence C. Dugan, William J. Benett, Elizabeth K. Wheeler
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Publication number: 20240008875Abstract: An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.Type: ApplicationFiled: September 19, 2023Publication date: January 11, 2024Inventors: Thomas S. Wilson, Ward Small, IV, William J. Benett, Jason M. Ortega, Duncan J. Maitland, Jonathan Hartman
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Patent number: 11864989Abstract: A system comprising first, second, and third shape memory polymers (SMPs); wherein (a) the first SMP is a biodegradable open cell foam that includes a first channel; (b) the second SMP includes a second channel and is included in the first channel; (c) the foam is in a first state and is configured to expand to a second state, radially outward from the second foam, in response to thermal stimulus; (d) the third SMP is between the first and second SMPs and includes a stent having a first strut that includes the third SMP and a second strut that includes the third SMP; and (e) each of the first, second, and third SMPs is coupled to a wire.Type: GrantFiled: October 14, 2020Date of Patent: January 9, 2024Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of CaliforniaInventors: Thomas S. Wilson, Duncan J. Maitland, Ward Small, IV, Patrick R. Buckley, William J. Benett, Jonathan Hartman, David Saloner
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Patent number: 11771435Abstract: An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.Type: GrantFiled: January 22, 2021Date of Patent: October 3, 2023Assignees: Lawrence Livermore National Security, LLC, The Texas A&M University SystemInventors: Thomas S. Wilson, Ward Small, IV, William J. Benett, Jason M. Ortega, Duncan J. Maitland, Jonathan Hartman
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Publication number: 20220022883Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.Type: ApplicationFiled: October 7, 2021Publication date: January 27, 2022Inventors: Jason M. Ortega, William J. Benett, Ward Small, Thomas S. Wilson, Duncan J. Maitland, Jonathan Hartman
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Patent number: 11141164Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.Type: GrantFiled: May 18, 2017Date of Patent: October 12, 2021Assignees: Lawrence Livermore National Security, LLC, The Texas A&M University SystemInventors: Jason M. Ortega, William J. Benett, Ward Small, Thomas S. Wilson, Duncan J. Maitland, Jonathan Hartman
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Publication number: 20210137527Abstract: An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.Type: ApplicationFiled: January 22, 2021Publication date: May 13, 2021Inventors: Thomas S. Wilson, Ward Small, IV, William J. Benett, Jason M. Ortega, Duncan J. Maitland, Jonathan Hartman
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Publication number: 20210022847Abstract: A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure.Type: ApplicationFiled: October 14, 2020Publication date: January 28, 2021Inventors: Thomas S. Wilson, Duncan J. Maitland, Ward Small, IV, Patrick R. Buckley, William J. Benett, Jonathan Hartman, David Saloner
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Patent number: 10898199Abstract: An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.Type: GrantFiled: May 18, 2018Date of Patent: January 26, 2021Assignees: Lawrence Livermore National Security, LLC, The Texas A&M University SystemInventors: Thomas S. Wilson, Ward Small, IV, William J. Benett, Jason M. Ortega, Duncan J. Maitland, Jonathan Hartman
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Patent number: 10806561Abstract: A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure.Type: GrantFiled: September 24, 2018Date of Patent: October 20, 2020Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of CaliforniaInventors: Thomas S. Wilson, Duncan J. Maitland, Ward Small, IV, Patrick R. Buckley, William J. Benett, Jonathan Hartman, David A. Saloner
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Publication number: 20190299209Abstract: A multi-channel optical detection system includes a base unit adapted to receive a multi-chamber assay cartridge having a plurality of reaction chambers loaded with a sample and an optical detection reagent, such as for example a fluorescence detection reagent, and an optical detection unit having a multi-channel optical block having a plurality of detection channels each with an associated light source, and an optic sensor. The optical detection unit is connectable to the base unit so that interrogation ports of the detection channels are optically aligned with optically transparent windows of the reaction chambers of a loaded cartridge.Type: ApplicationFiled: March 27, 2019Publication date: October 3, 2019Inventors: Lawrence C. Dugan, William J. Benett, Elizabeth K. Wheeler
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Publication number: 20190021838Abstract: A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure.Type: ApplicationFiled: September 24, 2018Publication date: January 24, 2019Inventors: Thomas S. Wilson, Duncan J. Maitland, Ward Small, IV, Patrick R. Buckley, William J. Benett, Jonathan Hartman, David A. Saloner
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Patent number: 10080642Abstract: A stent for treating a physical anomaly. The stent includes a skeletal support structure for expanding in the physical anomaly and a shape memory material coupled to the skeletal support structure.Type: GrantFiled: July 13, 2015Date of Patent: September 25, 2018Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of CaliforniaInventors: Thomas S. Wilson, Duncan J. Maitland, Ward Small, IV, Patrick R. Buckley, William J. Benett, Jonathan Hartman, David A. Saloner
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Publication number: 20180263631Abstract: An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.Type: ApplicationFiled: May 18, 2018Publication date: September 20, 2018Inventors: Thomas S. Wilson, Ward Small, IV, William J. Benett, Jason M. Ortega, Duncan J. Maitland, Jonathan Hartman
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Patent number: 10010327Abstract: An embodiment of the invention includes an expandable implant to endovascularly embolize an anatomical void or malformation, such as an aneurysm. An embodiment is comprised of a chain or linked sequence of expandable polymer foam elements. Another embodiment includes an elongated length of expandable polymer foam coupled to a backbone. Another embodiment includes a system for endovascular delivery of an expandable implant (e.g., shape memory polymer) to embolize an aneurysm. The system may include a microcatheter, a lumen-reducing collar coupled to the distal tip of the microcatheter, a flexible pushing element detachably coupled to an expandable implant, and a flexible tubular sheath inside of which the compressed implant and pushing element are pre-loaded. Other embodiments are described herein.Type: GrantFiled: December 14, 2011Date of Patent: July 3, 2018Assignees: Lawrence Livermore National Security, LLC, The Texas A&M University SystemInventors: Thomas S. Wilson, Ward Small, IV, William J. Benett, Jason M. Ortega, Duncan J. Maitland, Jonathan Hartman
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Patent number: 9939170Abstract: The rapid thermal cycling of a material is targeted. A microfluidic heat exchanger with an internal porous medium is coupled to tanks containing cold fluid and hot fluid. Fluid flows alternately from the cold tank and the hot tank into the porous medium, cooling and heating samples contained in the microfluidic heat exchanger's sample wells. A valve may be coupled to the tanks and a pump, and switching the position of the valve may switch the source and direction of fluid flowing through the porous medium. A controller may control the switching of valve positions based on the temperature of the samples and determined temperature thresholds. A sample tray for containing samples to be thermally cycled may be used in conjunction with the thermal cycling system. A surface or internal electrical heater may aid in heating the samples, or may replace the necessity for the hot tank.Type: GrantFiled: August 25, 2015Date of Patent: April 10, 2018Assignee: Lawrence Livermore National Security, LLCInventors: Neil Reginald Beer, William J. Benett, James M. Frank, Joshua R. Deotte, Christopher Spadaccini
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Patent number: 9909093Abstract: The present disclosure relates to a funnel apparatus for channeling cells onto a plurality of distinct, closely spaced regions of a seeding surface. The funnel apparatus has a body portion having an upper surface and a lower surface. The body portion forms a plurality of flow paths, at least one of which is shaped to have a decreasing cross-sectional area from the upper surface to the lower surface. The flow paths are formed at the lower surface to enable cells deposited into the flow paths at the upper surface of the funnel apparatus to be channeled into a plurality of distinct, closely spaced regions on the seeding surface positioned adjacent the lower surface.Type: GrantFiled: August 12, 2015Date of Patent: March 6, 2018Assignee: Lawrence Livermore National Security, LLCInventors: David Soscia, William J. Benett, Erik V. Mukerjee
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Publication number: 20170252045Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.Type: ApplicationFiled: May 18, 2017Publication date: September 7, 2017Inventors: Jason M. Ortega, William J. Benett, Ward Small, Thomas S. Wilson, Duncan J. Maitland, Jonathan Hartman
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Patent number: 9662119Abstract: A system for treating an aneurysm in a blood vessel or vein, wherein the aneurysm has a dome, an interior, and a neck. The system includes a shape memory polymer foam in the interior of the aneurysm between the dome and the neck. The shape memory polymer foam has pores that include a first multiplicity of pores having a first pore size and a second multiplicity of pores having a second pore size. The second pore size is larger than said first pore size. The first multiplicity of pores are located in the neck of the aneurysm. The second multiplicity of pores are located in the dome of the aneurysm.Type: GrantFiled: March 13, 2013Date of Patent: May 30, 2017Assignees: Lawrence Livermore National Security, LLC, The Texas A&M University SystemInventors: Jason M. Ortega, William J. Benett, Ward Small, Thomas S. Wilson, Duncan J Maitland, Jonathan Hartman
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Publication number: 20170044482Abstract: The present disclosure relates to a funnel apparatus for channeling cells onto a plurality of distinct, closely spaced regions of a seeding surface. The funnel apparatus has a body portion having an upper surface and a lower surface. The body portion forms a plurality of flow paths, at least one of which is shaped to have a decreasing cross-sectional area from the upper surface to the lower surface. The flow paths are formed at the lower surface to enable cells deposited into the flow paths at the upper surface of the funnel apparatus to be channeled into a plurality of distinct, closely spaced regions on the seeding surface positioned adjacent the lower surface.Type: ApplicationFiled: August 12, 2015Publication date: February 16, 2017Inventors: David SOSCIA, William J. BENETT, Erik V. MUKERJEE