Patents by Inventor William J. Bowers

William J. Bowers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11401810
    Abstract: A gasket for concrete structures such as tunnel segments includes a gasket body having a bottom face configured to be positioned against a surface of an associated tunnel segment. The bottom face may include a set of spaced indentations. First and second anchor members protrude from opposed side edges of the gasket adjacent the bottom face of the gasket. The anchor members are configured to attach the gasket to the tunnel segment during casting of a precast concrete member. The gasket body forms a groove in the concrete member and the anchor members form side channels in the groove. A respective fin can be provided on opposed side faces of the gasket. Should a defect be found in the original gasket, the gasket body can be removed from the groove of the concrete member relatively easily, even in the field, and a replacement gasket having corresponding anchor members, fins and indentations, can be snapped into the groove.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: August 2, 2022
    Assignee: Vertex, Inc.
    Inventors: William C. Andrick, Richard J. Bowers, Troy Davidson, James A. Westhoff, George M. Stamper
  • Patent number: 11051869
    Abstract: An electrosurgical system for tissue cauterization may include a user interface, a front panel display, an electrosurgical generator, a power supply of the electrosurgical generator, a system control of the electrosurgical generator, an RF system of the electrosurgical generator, and a bipolar forceps assembly. The electrosurgical system may be configured to cauterize a tissue. A tissue cauterization may include system activation, tissue impedance analysis, establishment of tissue cauterization parameters, monitoring and adjustment of tissue cauterization, and system deactivation. The establishment of tissue cauterization parameters may include establishing a tissue cauterization curve configured to minimize an amount of time required to cauterize a tissue.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: July 6, 2021
    Assignee: KOGENT SURGICAL, LLC
    Inventors: William J Bowers, Gregg D Scheller
  • Patent number: 10800853
    Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: October 13, 2020
    Assignee: Vaccinex, Inc.
    Inventors: Ernest S. Smith, Maurice Zauderer, William J. Bowers, Alan Jonason
  • Publication number: 20190322757
    Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.
    Type: Application
    Filed: July 2, 2019
    Publication date: October 24, 2019
    Inventors: Ernest S. Smith, Maurice Zauderer, William J. Bowers, Alan Jonason
  • Patent number: 10385136
    Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: August 20, 2019
    Assignee: Vaccinex, Inc.
    Inventors: Ernest S. Smith, Maurice Zauderer, William J. Bowers, Alan Jonason
  • Publication number: 20180168716
    Abstract: An electrosurgical system for tissue cauterization may include a user interface, a front panel display, an electrosurgical generator, a power supply of the electrosurgical generator, a system control of the electrosurgical generator, an RF system of the electrosurgical generator, and a bipolar forceps assembly. The electrosurgical system may be configured to cauterize a tissue. A tissue cauterization may include system activation, tissue impedance analysis, establishment of tissue cauterization parameters, monitoring and adjustment of tissue cauterization, and system deactivation. The establishment of tissue cauterization parameters may include establishing a tissue cauterization curve configured to minimize an amount of time required to cauterize a tissue.
    Type: Application
    Filed: February 15, 2018
    Publication date: June 21, 2018
    Inventors: William J Bowers, Gregg D Scheller
  • Patent number: 9924993
    Abstract: An electrosurgical system for tissue cauterization may include a user interface, a front panel display, an electrosurgical generator, a power supply of the electrosurgical generator, a system control of the electrosurgical generator, an RF system of the electrosurgical generator, and a bipolar forceps assembly. The electrosurgical system may be configured to cauterize a tissue. A tissue cauterization may include system activation, tissue impedance analysis, establishment of tissue cauterization parameters, monitoring and adjustment of tissue cauterization, and system deactivation. The establishment of tissue cauterization parameters may include establishing a tissue cauterization curve configured to minimize an amount of time required to cauterize a tissue.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: March 27, 2018
    Assignee: Kogent Surgical, LLC
    Inventors: William J Bowers, Gregg D Scheller
  • Publication number: 20180071010
    Abstract: A temperature monitoring electrosurgical system may include a first forceps arm, a second forceps arm, a temperature monitoring system, and a system control. The first forceps arm may include a first thermocouple electrically connected to a first temperature sense of the temperature monitoring system. The second forceps arm may include a second thermocouple electrically connected to a second temperature sense of the temperature monitoring system. The system control may be configured to compare a measured temperature of the first thermocouple and the second thermocouple to a user defined cauterization temperature setting. The system control may be configured to increase a bipolar output power if the measured temperature is less than the cauterization temperature setting. The system control may be configured to decrease the bipolar output power if the measured temperature is greater than the cauterization temperature setting.
    Type: Application
    Filed: August 14, 2017
    Publication date: March 15, 2018
    Applicant: Kogent Surgical, LLC
    Inventors: Gregg D. Scheller, William J. Bowers
  • Publication number: 20170198053
    Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 13, 2017
    Inventors: Ernest S. Smith, Maurice Zauderer, William J. Bowers, Alan Jonason
  • Patent number: 9598495
    Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: March 21, 2017
    Assignee: VACCINEX, INC.
    Inventors: Ernest S. Smith, Maurice Zauderer, William J. Bowers, Alan Jonason
  • Patent number: 9277957
    Abstract: An electrosurgical system may generally first and second electrodes coupled to an energy source operative to generate and deliver pulses of a biphasic radio frequency (RF) waveform to treat undesirable tissue in a patient. The pulses may induce non-thermal cell death in the patient's tissue while causing no or minimal muscle contractions in the treated patient. The pulses may be grouped in bursts wherein the pulses within a burst repeat at a particular pulse frequency.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: March 8, 2016
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventors: Gary L. Long, Gregory J. Bakos, David N. Plescia, Peter K. Shires, William J. Bowers
  • Patent number: 9249227
    Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: February 2, 2016
    Assignee: Vaccinex, Inc.
    Inventors: Ernest S. Smith, Maurice Zauderer, William J. Bowers, Alan Jonason
  • Publication number: 20150353641
    Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.
    Type: Application
    Filed: June 29, 2015
    Publication date: December 10, 2015
    Applicant: VACCINEX, INC.
    Inventors: Ernest S. Smith, Maurice Zauderer, William J. Bowers, Alan Jonason
  • Publication number: 20150110800
    Abstract: Provided herein are methods for alleviating symptoms in a subject having a neurodegenerative disorder, comprising administering to the subject an effective amount of an isolated binding molecule which specifically binds to semaphorin-4D (SEMA4D) or to its Plexin-B1 or Plexin-B2 receptors.
    Type: Application
    Filed: October 21, 2014
    Publication date: April 23, 2015
    Inventors: Ernest S. Smith, Maurice Zauderer, William J. Bowers, Alan Jonason
  • Publication number: 20140324041
    Abstract: An electrosurgical system for tissue cauterization may include a user interface, a front panel display, an electrosurgical generator, a power supply of the electrosurgical generator, a system control of the electrosurgical generator, an RF system of the electrosurgical generator, and a bipolar forceps assembly. The electrosurgical system may be configured to cauterize a tissue. A tissue cauterization may include system activation, tissue impedance analysis, establishment of tissue cauterization parameters, monitoring and adjustment of tissue cauterization, and system deactivation. The establishment of tissue cauterization parameters may include establishing a tissue cauterization curve configured to minimize an amount of time required to cauterize a tissue.
    Type: Application
    Filed: April 23, 2014
    Publication date: October 30, 2014
    Applicant: Kogent Surgical, LLC
    Inventors: William J. Bowers, Gregg D. Scheller
  • Publication number: 20140155471
    Abstract: Provided herein are methods of treating a neurological disease or injury in a subject comprising administering to the subject a recombinant adeno-associated virus (rAAV) vector comprising a DRP1-encoding nucleic acid, wherein the DRP1 encoded by the nucleic acid comprises a mutation compared to wild-type DRP1.
    Type: Application
    Filed: July 12, 2012
    Publication date: June 5, 2014
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Kim Tieu, William J. Bowers, Phillip M. Rappold
  • Publication number: 20140052126
    Abstract: An electrosurgical system may generally first and second electrodes coupled to an energy source operative to generate and deliver pulses of a biphasic radio frequency (RF) waveform to treat undesirable tissue in a patient. The pulses may induce non-thermal cell death in the patient's tissue while causing no or minimal muscle contractions in the treated patient. The pulses may be grouped in bursts wherein the pulses within a burst repeat at a particular pulse frequency.
    Type: Application
    Filed: August 15, 2012
    Publication date: February 20, 2014
    Applicant: Ethicon Endo-Surgery, Inc.
    Inventors: Gary L. Long, Gregory J. Bakos, David N. Plescia, Peter K. Shires, William J. Bowers
  • Patent number: 8119118
    Abstract: The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g., packaging cell lines or patients' cells, infected in vivo or ex vivo); particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: February 21, 2012
    Assignee: University of Rochester
    Inventors: Howard J. Federoff, William J. Bowers, John G. Frelinger, Richard A. Willis, Thomas G. Evans, Stephen Dewhurst, Khaled A. Tolba, Joseph D. Rosenblatt
  • Patent number: 8092791
    Abstract: The present invention relates to a method for producing herpes simplex virus (HSV) amplicon particles which includes co-transfecting a host cell with the following: (i) an amplicon vector comprising an HSV origin of replication, an HSV cleavage/packaging signal, and a heterologous transgene expressible in a patient, (ii) one or more vectors individually or collectively encoding all essential HSV genes but excluding all cleavage/packaging signals, and (iii) a vhs expression vector encoding a virion host shutoff protein; and then isolating HSV amplicon particles produced by the host cell, the HSV amplicon particles including the transgene. Also disclosed are a system and a kit for preparing HSV amplicon particles, HSV amplicon particles prepared according to the process of the present invention, and their use.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: January 10, 2012
    Assignee: University of Rochester
    Inventors: Howard J. Federoff, William J. Bowers
  • Publication number: 20110171257
    Abstract: Provided herein are HSV amplicon particles and methods of making and using HSV amplicon particles. The particles are generated using primary HSV isolates or packaging vectors derived from primary HSV isolates.
    Type: Application
    Filed: June 3, 2008
    Publication date: July 14, 2011
    Applicant: UNIVERSITY OF ROCHESTER
    Inventors: Stephen Dewhurst, William J. Bowers, Howard J. Federoff, John G. Frelinger, Michael C. Keefer