Patents by Inventor William J. Boyle
William J. Boyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200354464Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.Type: ApplicationFiled: June 18, 2020Publication date: November 12, 2020Applicants: AMGEN INC., AMGEN FREMONT INC.Inventors: William J. BOYLE, Francis H. MARTIN, Jose R. CORVALAN, C. Geoffrey DAVIS
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Publication number: 20200131271Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.Type: ApplicationFiled: January 9, 2020Publication date: April 30, 2020Applicants: AMGEN INC., AMGEN FREMONT INC.Inventors: William J. BOYLE, Francis H. MARTIN, Jose R. CORVALAN, C. Geoffrey DAVIS
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Publication number: 20170183417Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.Type: ApplicationFiled: September 2, 2016Publication date: June 29, 2017Applicant: AMGEN INC.Inventors: William J. BOYLE, Francis H. MARTIN, Jose R. CORVALAN, C. Geoffrey DAVIS
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Publication number: 20150266952Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.Type: ApplicationFiled: February 12, 2015Publication date: September 24, 2015Inventors: William J. BOYLE, Francis H. MARTIN, Jose R. CORVALAN, C. Geoffrey DAVIS
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Patent number: 8905946Abstract: A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.Type: GrantFiled: March 13, 2014Date of Patent: December 9, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: William J. Boyle, Wayne E. Cornish, Raleigh A. Purtzer
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Patent number: 8845583Abstract: An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature.Type: GrantFiled: January 10, 2007Date of Patent: September 30, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: William J. Boyle, David H. Burkett, Andy E. Denison, Benjamin C. Huter, Scott J. Huter, Arkady Kokish, Kent C. B. Stalker, Chicheng Wang, John D. Whitfield
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Publication number: 20140190230Abstract: A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.Type: ApplicationFiled: March 13, 2014Publication date: July 10, 2014Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: William J. Boyle, Wayne E. Cornish, Raleigh A. Purtzer
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Publication number: 20140147444Abstract: Selective binding agents of osteoprotegerin binding protein (OPGbp) are provided by the invention. More particularly, the invention provides for antibodies and antigen binding domains which selectively bind to OPGbp and may be used to prevent or treat conditions relating to loss of bone mass. Nucleic acid molecules encoding said antibodies and antigen binding domains, and expression vectors and host cells for the production of same are also provided.Type: ApplicationFiled: March 14, 2013Publication date: May 29, 2014Applicant: AMGEN INC.Inventors: Rajendra V. DESHPANDE, William J. BOYLE, John K. SULLIVAN, Anna Hitz
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Patent number: 8679035Abstract: A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.Type: GrantFiled: July 30, 2013Date of Patent: March 25, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: William J. Boyle, Wayne E. Cornish, Raleigh A. Purtzer
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Patent number: 8672991Abstract: A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter.Type: GrantFiled: March 15, 2010Date of Patent: March 18, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: William J. Boyle, Andy E. Denison, Benjamin C. Huter, Scott J. Huter, John E. Papp, Charles R. Peterson, Kent C. B. Stalker
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Publication number: 20130333430Abstract: A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.Type: ApplicationFiled: July 30, 2013Publication date: December 19, 2013Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: William J. Boyle, Wayne E. Cornish, Raleigh A. Purtzer
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Patent number: 8591540Abstract: An embolic filtering system includes a guide wire, a filter device disposed on the guide wire, a sheath adapted to maintain the filter device in an unexpanded position and a torque device having a lumen for receiving the guide wire and a locking mechanism for locking the torque device to the guide wire. The torque device may include a side port adapted to receive the proximal end of the sheath to allow a portion of the guide wire to shear the sheath from the guide wire through retraction of the sheath through the side port. The torque device may include an extension arm having a distal opening adapted to receive both the guide wire and the sheath. A second lumen may be used to allow a portion of the guide wire to shear the sheath away from the guide wire through retraction of the sheath through the second lumen.Type: GrantFiled: September 29, 2003Date of Patent: November 26, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: William J. Boyle, John E. Papp, Charles R. Peterson, Paul F. Muller, Donald Schwarten, Kathern J. Lind
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Patent number: 8500658Abstract: A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.Type: GrantFiled: October 28, 2010Date of Patent: August 6, 2013Assignee: Abbott Cardiovascular Systems Inc.Inventors: William J. Boyle, Wayne E. Cornish, Raleigh A. Purtzer
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Patent number: 8455629Abstract: Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.Type: GrantFiled: January 27, 2012Date of Patent: June 4, 2013Assignees: Amgen Inc., Medarex, Inc.Inventors: William J. Boyle, Eugene Medlock, John K. Sullivan, Robin L. Elliott, Frank Martin, Haichun Huang
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Patent number: 8409578Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.Type: GrantFiled: November 14, 2011Date of Patent: April 2, 2013Assignees: Amgen Inc., Amgen Fremont Inc.Inventors: William J. Boyle, Francis H. Martin, Jose R. Corvalan, C. Geoffrey Davis
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Patent number: 8367063Abstract: Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.Type: GrantFiled: May 18, 2010Date of Patent: February 5, 2013Assignees: Amgen, Inc., Medarex, Inc.Inventors: William J. Boyle, Eugene Medlock, John K. Sullivan, Robin L. Elliott, Frank Martin, Haichun Huang
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Patent number: 8262689Abstract: A self-expanding basket for use in conjunction with an embolic filtering device has a proximal set of struts which are connected to a distal set of struts by a bending region which provides enhanced bending characteristics to the basket. The bending region can be formed by intermediate links which are extremely flexible and bendable to allow the basket to be delivered through tortuous anatomy. The intermediate links are extremely flexible and create a mechanical hinge-like connection between the proximal and distal strut assemblies. The basket thus is capable of substantial bending when being delivered through the patient's vasculature and will bend and conform to the patient's anatomy once positioned for filtering purposes. The intermediate links can also lengthen, when needed, when positioned in a curved vessel in the patient's vasculature, when needed.Type: GrantFiled: September 28, 2001Date of Patent: September 11, 2012Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Gary Schneiderman, Anuja H. Patel, Paul F. Muller, William J. Boyle, Thomas A. Hassing, Thomas H. Majcher
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Publication number: 20120156725Abstract: Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.Type: ApplicationFiled: January 27, 2012Publication date: June 21, 2012Applicants: MEDAREX, INC., AMGEN INC.Inventors: William J. Boyle, Eugene Medlock, John K. Sullivan, Robin L. Elliott, Frank Martin, Haichun Huang
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Publication number: 20120109108Abstract: A guide wire for use in a medical procedure having a shapeable tip integral with and made from the distal end of a superelastic nitinol distal section of the guide wire, wherein the shapeable tip can be finger kinked. Such a guide wire includes an elongated core made from a superelastic nitinol alloy at the distal end, the distal end of the elongated core having a tapered section leading to a shapeable distal tip. The shapeable tip is an extension of the distal end of the nitinol distal section, and includes permanent strain hardening from at least two different radial directions imparting crystallographic texture in the radial directions that eliminate superelasticity so that permanent deformation can be achieved with finger pressure.Type: ApplicationFiled: October 28, 2010Publication date: May 3, 2012Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: William J. Boyle, Wayne E. Cornish, Raleigh A. Purtzer
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Publication number: 20120087923Abstract: Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.Type: ApplicationFiled: November 14, 2011Publication date: April 12, 2012Inventors: William J. Boyle, Francis H. Martin, Jose R. Corvalan, C. Geoffrey Davis