Patents by Inventor William J. Checovich

William J. Checovich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for quantitating competitive binding of molecules to proteins utilizing fluorescence polarization
    Patent number: 6511815
    Abstract: The system comprises mixing a fluorescence-emitting compound that binds to the steroid hormone receptors in a solution containing the steroid hormone receptors. Then, measuring the fluorescence polarization of the solution. Subsequently, incubating the solution with at least one molecule that may compete with the compound for interaction with the steroid hormone receptors. Measuring the fluorescence polarization of the solution again. Finally, comparing the fluorescence polarization measurements to quantify any competitive interaction.
    Type: Grant
    Filed: December 20, 1999
    Date of Patent: January 28, 2003
    Assignee: PanVera LLC
    Inventors: Thomas J. Burke, Randall E. Bolger, Kerry M. Ervin, Robert G. Lowery, William J. Checovich
  • Processes for receptpor screening
    Publication number: 20020146741
    Abstract: A method is provided for measuring competitive binding activity of molecules to nuclear receptors comprising mixing a fluorescence-emitting compound that specifically binds to steroid hormone receptors in a solution wherein the fluorescence-emitting compound is in concentration below the dissociation constant and the steroid hormone receptors are at or above the dissociation constant using fluorescence polarization.
    Type: Application
    Filed: July 30, 2001
    Publication date: October 10, 2002
    Inventors: Cale M. Halbleib, Kerry M. Ervin, Mohammed S. Shekhani, Robert G. Lowery, William J. Checovich, Thomas J. Burke
  • Method and kit for detecting nucleic acid cleavage utilizing a covalently attached fluorescent tag
    Patent number: 5786139
    Abstract: The present invention is based on the degradation of a fluorescence labeled nucleic acid such as DNA (F-DNA), RNA (F-RNA) or DNA/RNA substrate. The label may be covalently attached to the relatively high volume substrate at one position or many positions. The nucleic acid is then put in contact with another substance and activity is detected by Fluorescence Polarization.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: July 28, 1998
    Assignee: PanVera Corporation
    Inventors: Thomas J. Burke, Randall E. Bolger, William J. Checovich, David V. Thompson
  • Use of lysophosphatidic acids to enhance fibronectin binding
    Patent number: 5480877
    Abstract: Lysophosphatidic acids are used to enhance fibronectin binding. This assists in the process of wound healing. The acids are exogenously supplied. In one aspect, a kit is provided containing a skin salve that contains the acid or a salt thereof.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: January 2, 1996
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Deane F. Mosher, Jr., William J. Checovich