Patents by Inventor William J. Coates

William J. Coates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenylpyrimidone derivatives
    Patent number: 5290933
    Abstract: This invention relates to phenylpyrimidone derivatives which have bronchodilator activity. A compound of the invention is N-methyl 1,6-dihydro-6-oxo-2-(2-propoxyphenyl)pyrimidine-5-carboxamide.
    Type: Grant
    Filed: November 14, 1991
    Date of Patent: March 1, 1994
    Assignee: SmithKline & French Laboratories Limited
    Inventor: William J. Coates
  • Chemical compounds
    Patent number: 5254571
    Abstract: This invention relates to phenylpyridone derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 6-(2-propoxyphenyl)-1,2-dihydro-2-oxopyridine-3-carboxamide.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: October 19, 1993
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: William J. Coates, Sean T. Flynn
  • Thiadiazinones for stimulating cardiac activity
    Patent number: 5246928
    Abstract: This invention relates to N-phenylpyridone derivatives which have inotropic, vasodilator and bronchodilator activity. A compound of the invention is 5-methyl-6-[4-(4-oxo-1,4-dihydropyridin-1-yl)phenyl]-4,5-dihydro-3(2H)pyri dazinone.
    Type: Grant
    Filed: July 10, 1991
    Date of Patent: September 21, 1993
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Multiport particle detection apparatus utilizing a plenum having a plurality of spatically separate channels in fluid combination
    Patent number: 5164604
    Abstract: Detection apparatus employs a plurality of conduits, a plurality of photosensors, and a laser in a multi-port forward-scattering geometry to detect particles for each of a plurality of spatial sections (S.sub.1, . . . S.sub.n) of an enclosure. The photosensors are provided in two sets arranged at two different scattering angles to discriminate smoke from other particulate matter in sample flows which flow along the conduits and intersect the laser beam. The sample flows are discharged into a plenum and removed from the plenum via a single manifold. The laser can be backed up by an auxiliary laser.
    Type: Grant
    Filed: May 1, 1991
    Date of Patent: November 17, 1992
    Assignee: Allied-Signal Inc.
    Inventors: Harvey V. Blair, John McLin, Joseph F. Halik, William J. Coates
  • Pyrimido[4,5-d]pyrimidine derivatives for use as bronchodilators
    Patent number: 5162316
    Abstract: This invention relates to pyrimidopyrimidine derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 7-cyclopropylamino-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d] pyrimidine.
    Type: Grant
    Filed: March 13, 1991
    Date of Patent: November 10, 1992
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • 2-(substituted phenyl)-4-oxo-quinazolines
    Patent number: 5147875
    Abstract: This invention relates to quinazolinone derivatives which have bronchodilator activity. A compound of the invention is 2-(2-propoxyphenyl)quinazolin-4(3H)-one.
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: September 15, 1992
    Assignee: Sanshin Kogyo Kabishiki Kaisha
    Inventors: William J. Coates, Lawrence I. Kruse
  • Phenylpyrimidones
    Patent number: 5118686
    Abstract: This invention relates to phenylpyrimidone derivatives which have bronchodilator activity. A compound of the invention is 4-cyano-6-hydroxy-2-(2-propoxyphenyl)pyrimidine.
    Type: Grant
    Filed: April 25, 1990
    Date of Patent: June 2, 1992
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, Derek A. Rawlings
  • Pyrimidone derivatives as bronchodilators
    Patent number: 5075310
    Abstract: This invention relates to fused pyrimidine derivatives which have bronchodilator activity. A compound of this invention is 2-(2-propoxyphenyl)thieno[2,3-d]pyrimidin-4(3H)-one.
    Type: Grant
    Filed: June 23, 1989
    Date of Patent: December 24, 1991
    Assignee: Smith Kline & French Laboratories, Ltd.
    Inventors: William J. Coates, Derek A. Rawlings
  • 2-Substituted purinone having phosphodiesterase inhibitory activity
    Patent number: 5073559
    Abstract: This invention relates to phenylpurinone derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxy-5-chlorophenyl)purin-6-one.
    Type: Grant
    Filed: July 19, 1989
    Date of Patent: December 17, 1991
    Assignee: Smith Kline & French Laboratories, Ltd.
    Inventor: William J. Coates
  • Chemical compounds
    Patent number: 5066653
    Abstract: Phosphodiesterase (type III) inhibitors having the formula: ##STR1## wherein R.sup.4 is hydrogen and A is a dihydro-1,2,4-triazin-3-one group or a dihydro-1,2,4-triazin-6-one group which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: November 19, 1991
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Chemical compounds
    Patent number: 5047404
    Abstract: This invention relates to fused pyrimidine derivatives which have bronchodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxyphenyl)pyrido[2,3-d]pyrimid-4(3H)-one.
    Type: Grant
    Filed: June 13, 1989
    Date of Patent: September 10, 1991
    Assignee: Smith Kline & French Laboratories, Ltd.
    Inventors: William J. Coates, Sean T. Flynn, Derek A. Rawlings
  • Pyridazinone derivatives
    Patent number: 4962110
    Abstract: The invention relates to 2-aminopyrimidinone derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(1,4-dihydro-4-oxo-2-pyrimidinylamino)phenyl]-5-methyl-4,5-dihydro-3( 2H)-pyridazinone.
    Type: Grant
    Filed: August 10, 1989
    Date of Patent: October 9, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: John C. Emmett, William J. Coates
  • Novel guanidino pyridazinones as cardiac stimulants
    Patent number: 4946842
    Abstract: The invention relates to phenyl dihydropyridazinone derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.3 -benzyl-N.sup.2 -cyanoguanidino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: August 7, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, John C. Emmett, Robert A. Slater
  • N-phenylpyridone type III phosphodiesterases
    Patent number: 4906628
    Abstract: Phosphodiesterase (type III) inhibitors having the formula: ##STR1## which are useful in stimulating cardiac activity and in treating congestive heart failure and bronchoconstriction, pharmaceutical compositions including these inhibitors, and methods of using these compounds to produce phosphodiesterase (type III) inhibition in mammals.
    Type: Grant
    Filed: October 14, 1986
    Date of Patent: March 6, 1990
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities
    Patent number: 4885301
    Abstract: This invention relates to purinone derivatives which have bronchodilator, vasodilator and anti-allergic activities. A compound of the invention is 2-(2-propoxyphenyl)-6-purinone.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: December 5, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Heterocyclic compounds
    Patent number: 4861773
    Abstract: The invention relates to thiadiazinone derivatives that have utility as cardiac stimulants. A compound of the invention is 7-(1H-imidazol-1-yl)-9,9a-dihydroindeno[1,2-e][1,3,4]-thiadiazin-2(3H)-one .
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: August 29, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: William J. Coates, Lawrence I. Kruse
  • 5-phenyl-3[2H]-pyridazinone derivatives
    Patent number: 4820819
    Abstract: This invention relates to (isopropyl and tertiary butyl-amino-2-hydroxypropoxy)phenyl-3[2H]-pyridazinones which have .beta.-adrenoceptor antagonist activity.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: April 11, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Anthony M. Roe, William J. Coates, Robert A. Slater, Stephen P. Breukelman
  • Methylamidine compounds
    Patent number: 4766123
    Abstract: The invention relates to cyanoalkanimidamido derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.2 -cyanoethanimidamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: February 10, 1987
    Date of Patent: August 23, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Cyanoamidine compounds and derivatives thereof
    Patent number: 4766122
    Abstract: The invention relates to cyanoalkanimidamido derivatives that have utility as cardiac stimulants. A compound of the invention is 6-[4-(N.sup.2 -cyanopropanimidamido)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone.
    Type: Grant
    Filed: March 26, 1986
    Date of Patent: August 23, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: William J. Coates
  • Pharmaceutical compositions having .beta.-adrenoceptor antagonist activity employing pyridazinone derivatives
    Patent number: 4678786
    Abstract: This invention relates to (isopropyl and tertiary butyl-amino-2-hydroxypropoxy)phenyl-3[2H]-pyridazinones which have .beta.-adrenoceptor antagonist activity.
    Type: Grant
    Filed: August 13, 1986
    Date of Patent: July 7, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Anthony M. Roe, William J. Coates, Robert A. Slater, Stephen P. Breukelman, George D. Meakins