Abstract: The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity, and/or modulate a gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against target gene expression.

Abstract: The present solution addresses the displaying of multiple levels of information in a constrained display footprint in a manner that allows a user to be vigilant over the information. Systems and methods are described herein for organizing data and information queries against data sources in a relational display with hierarchical grids, linked to query results, score displays, and alert monitoring. In an embodiment of the present solution, a system allows an analyst to view results and status from monitoring numerous and persistent queries against real-time data streams. Many of these queries may be inter-related and composed in a way to comprehensively analyze a problem. To display, monitor, and interact with a collection of queries, the present solution provides a relational display that makes use of a set of grids via a feature referred to as “grid of grids”. The grids may be arranged in a hierarchy of any number of levels.

Abstract: The present solution addresses the displaying of multiple levels of information in a constrained display footprint in a manner that allows a user to be vigilant over the information. Systems and methods are described herein for organizing data and information queries against data sources in a relational display with hierarchical grids, linked to query results, score displays, and alert monitoring. In an embodiment of the present solution, a system allows an analyst to view results and status from monitoring numerous and persistent queries against real-time data streams. Many of these queries may be inter-related and composed in a way to comprehensively analyze a problem. To display, monitor, and interact with a collection of queries, the present solution provides a relational display that makes use of a set of grids via a feature referred to as “grid of grids”. The grids may be arranged in a hierarchy of any number of levels.

Abstract: A contract authority for use by an automated system of record and an automated negotiations engine for iterative, multivariate negotiations which stores each set of terms proposed at each iteration to form the basis of the system of record. The contract authority of the invention assigns a unique identifier to each negotiated transaction and enables the participants to use that number to track all activities against the transaction for analysis and reporting purposes.

Abstract: An automated negotiations engine for iterative, multivariate negotiations of developments of products and programs which stores each set of terms proposed at each iteration to form the basis of the system of record. Active templates created using the present invention can be used to inform other systems automatically of agreed upon terms so that products or computer programs can be generated by them.

Abstract: An process mining system for analyzing the processes used to implement negotiated contracts and other agreements stored in an automated system of record. Using unique identifiers assigned by the contract authority of the invention, process mining can be done to evaluate the effectiveness of processes used to implement one or more sets of negotiations.

Abstract: An automated system of record creates and administers a sponsored community for participants. Participants use an automated negotiations engine for iterative, multivariate negotiations that stores each set of terms at each iteration to form a system of record. The automated negotiations engine can also be used to propose and negotiate specifications, prototypes and implementations of other systems. An active contract feature informs the results of such negotiations, by incorporating predefined templates to track activity related to the concluded negotiation. The system implements a higher level of security by validating activities against the originally negotiated terms. A contract authority assigns a unique identifier to each transaction to track activities against the transaction for analysis and reporting. A multiple repository enables users to maintain the non-repudiation data for transactions in which they participate at user designated locations.

Abstract: An automated underwriting auction processor is presented. States, municipalities, and other non-federal authorities issue municipal securities to an underwriter or syndicate of underwriters during an underwriting period. The underwriters then trade the securities in a secondary market. The efficiency and fairness of this process is improved using a networked system, which includes multiple computers or workstations, connected to an automated auction processor. The processor provides issuers and participants equal real-time access to the underwriting process. Moreover, the automated auction processor provides a universal underwriting protocol to ensure that only qualified issuers and participants are allowed to participate. This results in a fair and more efficient underwriting process compared to the traditional sealed-bid auction and negotiated underwriting processes.