Patents by Inventor William J. Gottstein

William J. Gottstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid sulfone methylene diol mixed esters
    Patent number: 4444687
    Abstract: 2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid sulfone and salts and esters thereof were synthesized and found to be potent inhibitors of .beta.-lactamases.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: April 24, 1984
    Assignee: Bristol-Myers Company
    Inventor: William J. Gottstein
  • 2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid sulfone and salts and esters thereof
    Patent number: 4380512
    Abstract: 2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid sulfone and salts and esters thereof were synthesized and found to be potent inhibitors of .beta.-lactamases.
    Type: Grant
    Filed: June 8, 1981
    Date of Patent: April 19, 1983
    Assignee: Bristol-Myers Company
    Inventor: William J. Gottstein
  • Derivatives of 6-bromo penicillanic acid
    Patent number: 4340539
    Abstract: 2.beta.-Chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid sulfone and salts and esters thereof were synthesized and found to be potent inhibitors of .beta.-lactamases.
    Type: Grant
    Filed: December 11, 1980
    Date of Patent: July 20, 1982
    Assignee: Bristol-Myers Company
    Inventor: William J. Gottstein
  • 7-.alpha.-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxyl ic acids
    Patent number: 4297489
    Abstract: Certain 7-acylamido-3-(1-carboxy-loweralkyl-tetrazol-5-ylthiomethyl)-3-cephem-4-ca rboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. In a preferred embodiment the 7-substituent was 2'-aminomethylphenylacetamido.
    Type: Grant
    Filed: June 27, 1975
    Date of Patent: October 27, 1981
    Assignee: Bristol-Myers Company
    Inventors: William J. Gottstein, Murray A. Kaplan, Alphonse P. Granatek
  • 7-Amino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
    Patent number: 4182863
    Abstract: Certain 7-acylamido-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxyl ic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. In a preferred embodiment the 7-substituent was 2'-aminomethylphenylacetamido.
    Type: Grant
    Filed: August 5, 1976
    Date of Patent: January 8, 1980
    Assignee: Bristol-Myers Company
    Inventors: William J. Gottstein, Murray A. Kaplan, Alphonse P. Granatek
  • Certain 7-.alpha.-substituted-.alpha.-hydroxyacetamido-3-(1-carboxymethyltetrazo l-5-yl-thiomethyl)-3-cephem-4-carboxylic acids
    Patent number: 4172196
    Abstract: Certain 7-acylamido-3-(1-carboxymethyltetrazol-5-yl-thiomethyl)-3-cephem-4-carboxy lic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent anti-bacterial agents which exhibited good aqueous solubilty. In a preferred embodiment the 7-substituent was D-.alpha.-hydroxyphenylcetamido.
    Type: Grant
    Filed: July 28, 1976
    Date of Patent: October 23, 1979
    Assignee: Bristol-Myers Company
    Inventors: William J. Gottstein, Murray A. Kaplan, Alphonse P. Granatek
  • Certain 7(o-amino-methyl- or methylaminomethylphenyl- or cyclohexadienyl- or thienylacetamide)-3[1-carboxymethyl-(or ethyl- or propyl-)-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids
    Patent number: 4100346
    Abstract: Certain 7-acylamido-3-[1-carboxymethyl-(or ethyl- or propyl-)-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. A preferred embodiment was 7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl )-3-cephem-4-carboxylic acid.
    Type: Grant
    Filed: June 11, 1976
    Date of Patent: July 11, 1978
    Assignee: Bristol-Myers Company
    Inventors: William J. Gottstein, Murray A. Kaplan, Alphonse P. Granatek
  • 7-Cyclizedamino-3-heterothiomethyl cephalosporin derivatives
    Patent number: 4091213
    Abstract: Compounds of the formula ##STR1## wherein A is hydrogen, hydroxy, methyl or methoxy,R.sup.1 is hydrogen, sodium or potassium,R.sup.2 is carboxyl or 2-furyl or an aliphatic, aromatic or heterocyclic radical to which there is also attached a strongly acidic group in the form of its sodium or potassium salt, andR.sup.3 is tetrazol-5-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-2-yl, 1,3,4-oxadiazol-3-yl or 1,2,4-triazol-5-yl, each of such groups being unsubstituted or substituted with one or two lower alkyl groups of one to four carbon atoms are prepared by reacting the appropriate aldehyde with the corresponding amphoteric cephalosporin. Preferred products have the structure ##STR2## in which A is --H or --SO.sub.3 Na.
    Type: Grant
    Filed: January 10, 1977
    Date of Patent: May 23, 1978
    Assignee: Bristol-Myers Company
    Inventors: Murray A. Kaplan, William J. Gottstein, Alphonse P. Granatek
  • Cephalosporins derivatives 7-cyclized .alpha.-amino-3-heterothio
    Patent number: 4064345
    Abstract: Compounds of the formula ##STR1## wherein A is hydrogen, hydroxy, methyl or methoxy,R.sup.1 is hydrogen, sodium or potassium,R.sup.2 is carboxyl or 2-furyl or an aliphatic, aromatic or heterocyclic radical to which there is also attached a strongly acidic group in the form of its sodium or potassium salt, andR.sup.3 is tetrazol-5-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazol-2-yl, 1,3,4-oxadiazol-3-yl or 1,2,4-triazol-5-yl, each of such groups being unsubstituted or substituted with one or two lower alkyl groups of one to four carbon atoms are prepared by reacting the appropriate aldehyde with the corresponding amphoteric cephalosporin. Preferred products have the structure ##STR2## in which A is --H or --SO.sub.3 Na.
    Type: Grant
    Filed: November 26, 1976
    Date of Patent: December 20, 1977
    Assignee: Bristol-Myers Company
    Inventors: Murray A. Kaplan, William J. Gottstein, Alphonse P. Granatek
  • Derivatives of 7-(cyclized)phenylglycyl-3-triazolo-thio methyl cephalosporin
    Patent number: 4061862
    Abstract: Compounds of the formula ##STR1## wherein A is hydrogen, hydroxy, methyl or methoxy,R.sup.1 is hydrogen, sodium or potassium, andR.sup.2 is 1,2,3-triazol-5-yl, such group being unsubstituted or substituted with one or two lower alkyl groups of one to four carbon atoms are prepared by reacting the appropriate aldehyde with the corresponding amphoteric cephalosporin.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: December 6, 1977
    Assignee: Bristol-Myers Company
    Inventors: Murray A. Kaplan, William J. Gottstein, Alphonse P. Granatek
  • Certain derivatives of particular 3-thiolated cephalosporins
    Patent number: 4026888
    Abstract: Compounds of the formula ##STR1## wherein A is hydrogen, hydroxy, methyl or methoxy,R.sup.1 is hydrogen, sodium or potassium,R.sup.2 is carboxyl or an aliphatic, aromatic or heterocyclic radical to which there is also attached a strongly acidic group in the form of its sodium or potassium salt, andR.sup.3 is 1,2,3-triazol-5-yl, such group being unsubstituted or substituted with one or two lower alkyl groups of one to four carbon atoms are prepared by reacting the appropriate aldehyde with the corresponding amphoteric cephalosporin.
    Type: Grant
    Filed: January 30, 1976
    Date of Patent: May 31, 1977
    Assignee: Bristol-Myers Company
    Inventors: Murray A. Kaplan, William J. Gottstein, Alphonse P. Granatek