Patents by Inventor William J. Guilford

William J. Guilford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fused Tricyclic Heterocyclic Compounds and Uses Thereof
    Publication number: 20230038929
    Abstract: The present disclosure provides compounds that are inhibitors of PIKfyve and/or PI3 kinases, and are therefore useful for the treatment of neurological diseases that are treatable by inhibition of PIKfyve. Also provided are pharmaceutical compositions containing such compounds, and methods of treatment using such compounds.
    Type: Application
    Filed: December 4, 2020
    Publication date: February 9, 2023
    Applicant: Verge Analytics, Inc.
    Inventors: Mark D. Rosen, Robert A. Galemmo, JR., William J. Guilford, Weiling Liang, Irene Y. Choi, Bryan Kopek, Jane Rhodes
  • EP2 AND EP4 AGONISTS AS AGENTS FOR THE TREATMENT OF INFLUENZA A VIRAL INFECTION
    Publication number: 20150374715
    Abstract: The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof.
    Type: Application
    Filed: February 27, 2015
    Publication date: December 31, 2015
    Inventors: Daryl Faulds, William J. Guilford, Wolfgang Seifert
  • COMBINATION THERAPY TREATMENT FOR VIRAL INFECTIONS
    Publication number: 20150196578
    Abstract: Therapeutics which employ a combination of an antiviral agent and an EP4 receptor agonist for the treatment of human respiratory diseases associated with viral infections are described. Viral infections may include an influenza A virus, for example H1N1, H3N2 and H5N1, and mutations thereof, and/or a coronavirus, for example a virus that causes severe acute respiratory syndrome, “SARS”.
    Type: Application
    Filed: December 10, 2014
    Publication date: July 16, 2015
    Inventors: William J. Guilford, Daryl H. Faulds
  • EP2 and EP4 agonists as agents for the treatment of influenza a viral infection
    Patent number: 8980944
    Abstract: The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: March 17, 2015
    Assignee: Gemmus Pharma Inc.
    Inventors: Daryl Faulds, William J. Guilford, Wolfgang Seifert
  • BERAPROST ISOMER AS AN AGENT FOR THE TREATMENT OF VIRAL INFECTION
    Publication number: 20140275237
    Abstract: In various embodiments the use of single isomer of beraprost as a therapeutic for the treatment of viral disease and other pathologies associated with the induction of a cytokine storm, such as influenza A viruses and the SARS-causing coronvirus and mutations thereof is provided.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: Gemmus Pharma Inc.
    Inventors: DARYL H. FAULDS, WILLIAM J. GUILFORD
  • EP2 AND EP4 AGONISTS AS AGENTS FOR THE TREATMENT OF INFLUENZA A VIRAL INFECTION
    Publication number: 20120190739
    Abstract: The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof.
    Type: Application
    Filed: March 28, 2011
    Publication date: July 26, 2012
    Applicant: GEMMUS PHARMA INC.
    Inventors: Daryl Faulds, William J. Guilford, Wolfgang Seifert
  • COMBINATION THERAPY TREATMENT FOR VIRAL INFECTIONS
    Publication number: 20120190637
    Abstract: Therapeutics which employ a combination of an antiviral agent and an EP4 receptor agonist for the treatment of human respiratory diseases associated with viral infections are described. Viral infections may include an influenza A virus, for example H1N1, H3N2 and H5N1, and mutations thereof, and/or a coronavirus, for example a virus that causes severe acute respiratory syndrome, “SARS”.
    Type: Application
    Filed: October 13, 2010
    Publication date: July 26, 2012
    Applicant: GEMMUS PHARMA, INC.
    Inventors: William J. Guilford, Daryl H. Faulds
  • EP2 and EP4 agonists as agents for the treatment of influenza a viral infection
    Patent number: 8183286
    Abstract: The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: May 22, 2012
    Assignee: Gemmus Pharma Inc.
    Inventors: Daryl Faulds, William J. Guilford, Wolfgang Seifert
  • EP2 and EP4 agonists as agents for the treatment of influenza a viral infection
    Publication number: 20090170931
    Abstract: The present invention is directed to the use of EP2 and/or EP4 agonists as therapeutics for the treatment of diseases associated with influenza A viruses, such as for example H5N1 and mutations thereof.
    Type: Application
    Filed: November 14, 2007
    Publication date: July 2, 2009
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Daryl Faulds, William J. Guilford, Wolfgang Seifert
  • Crystalline acid of lipoxin A4 analogs and method of making
    Publication number: 20090036530
    Abstract: This invention is directed to a crystalline acid of a lipoxin A4 analog of Formula (II): wherein: R1 is —O—, —S(O)t— (where t is 0, 1 or 2), or a straight or branched alkylene chain; and R2 is aryl (optionally substituted by one or more substituents selected from alkyl, alkoxy, halo, haloalkyl and haloalkoxy) or aralkyl (optionally substituted by one or more substituents selected from f alkyl, alkoxy, halo, haloalkyl and haloalkoxy); and wherein the compound of Formula (II) is a single stereoisomer or any mixture of stereoisomers. This crystalline acid is useful in treating disease-states characterized by inflammation, such as inflammatory and autoimmune disorders or pulmonary or respiratory tract inflammations in humans. Methods of preparing the crystalline acid are also described.
    Type: Application
    Filed: June 30, 2008
    Publication date: February 5, 2009
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Klaus Bartel, Danja Grossbach, William J. Guilford, Michael Sander, Gabriele Winter
  • Crystalline acid of lipoxin A4 analogs and method of making
    Publication number: 20080182901
    Abstract: This invention is directed to a crystalline acid of a lipoxin A4 analog of Formula (II): wherein: R1 is —O—, —S(O)t— (where t is 0, 1 or 2), or a straight or branched alkylene chain; and R2 is aryl (optionally substituted by one or more substituents selected from alkyl, alkoxy, halo, haloalkyl and haloalkoxy) or aralkyl (optionally substituted by one or more substituents selected from f alkyl, alkoxy, halo, haloalkyl and haloalkoxy); and wherein the compound of Formula (II) is a single stereoisomer or any mixture of stereoisomers. This crystalline acid is useful in treating disease-states characterized by inflammation, such as inflammatory and autoimmune disorders or pulmonary or respiratory tract inflammations in humans. Methods of preparing the crystalline acid are also described.
    Type: Application
    Filed: December 3, 2007
    Publication date: July 31, 2008
    Applicant: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Klaus Bartel, Danja Grossbach, William J. Guilford, Michael Sander, Gabriele Winter
  • Lipoxin Aanalogs
    Patent number: 7223798
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: May 29, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: John G Bauman, William J Guilford, John F Parkinson, Werner Skuballa, Babu Subramanyam
  • Lipoxin A4 analogs
    Patent number: 6831186
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: December 14, 2004
    Assignee: Schering Aktiengesellschft
    Inventors: John G Bauman, William J Guilford, John F Parkinson, Werner Skuballa, Babu Subramanyam
  • Lipoxin A4 analogs
    Publication number: 20040162433
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): 1
    Type: Application
    Filed: February 18, 2004
    Publication date: August 19, 2004
    Applicant: Schering Aktiengesellschaft
    Inventors: John G. Bauman, William J. Guilford, John F. Parkinson, Werner Skuballa, Babu Subramanyam
  • Benzamidine derivatives and their use as anti-coagulants
    Patent number: 6686364
    Abstract: This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: February 3, 2004
    Assignee: Berlex Laboratories, Inc.
    Inventors: Brad O. Buckman, David D. Davey, William J. Guilford, Michael M. Morrissey, Howard P. Ng, Gary B. Phillips, Shung C. Wu, Wei Xu
  • Lipoxin A4 analogs
    Publication number: 20030139376
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): 1
    Type: Application
    Filed: October 22, 2002
    Publication date: July 24, 2003
    Applicant: Schering Aktiengesellschaft
    Inventors: John G. Bauman, William J. Guilford, John F. Parkinson, Werner Skuballa, Babu Subramanyam
  • Benzamidine derivatives and their use as anti-coagulants
    Patent number: 6479485
    Abstract: This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: November 12, 2002
    Assignee: Berlex Laboratories, Inc.
    Inventors: Brad O. Buckman, David D. Davey, William J. Guilford, Michael M. Morrissey, Howard P. Ng, Gary B. Phillips, Shung C. Wu, Wei Xu
  • Benzamidine derivatives and their use as anti-coagulants
    Patent number: 6465459
    Abstract: This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: October 15, 2002
    Assignee: Berlex Laboratories, Inc.
    Inventors: Brad O. Buckman, David D. Davey, William J. Guilford, Michael M. Morrissey, Howard P. Ng, Gary B. Phillips, Shung C. Wu, Wei Xu
  • Benzamidine derivatives and their use as anti-coagulants
    Publication number: 20020035109
    Abstract: This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-,states characterized by thrombotic activity.
    Type: Application
    Filed: August 7, 2001
    Publication date: March 21, 2002
    Applicant: Berlex Laboratories, Inc.
    Inventors: Brad O. Buckman, David D. Davey, William J. Guilford, Michael M. Morrissey, Howard P. Ng, Gary B. Phillips, Shung C. Wu, Wei Xu
  • Benzamidine derivatives and their use as anti-coagulants
    Publication number: 20020032223
    Abstract: This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.
    Type: Application
    Filed: August 8, 2001
    Publication date: March 14, 2002
    Applicant: Berlex Laboratories, Inc.
    Inventors: Brad O. Buckman, David D. Davey, William J. Guilford, Michael M. Morrissey, Howard P. Ng, Gary B. Phillips, Shung C. Wu, Wei Xu