Abstract: This invention concerns Reward Deficiency Syndrome (RDS) and obesity, and the role of catecholaminergic pathways in aberrant substance-seeking behavior, in particular cravings for carbohydrates. Also described are new nutrigenomic formulas having unique combinations of ingredients having a generalized anti-craving effect are, which can inhibit carbohydrate bingeing, inducing significant healthy fat loss and relapse prevention, as well genetic testing for certain polymorphisms correlated with RDS behaviors.

Abstract: A formulation delivery system is disclosed. When configured as a pro-liposome oral tablet, the tablet comprises a blend of at least one Iiposome forming ingredient, at least one active ingredient and at least one co-disintegrant. After ingestion at least a portion of the tablet disintegrates in a portion of an alimentary system to provide one or more in situ Iiposome encapsulated active ingredients. A method of producing the pro-liposome oral tablet and a method of therapeutically dosing with the pro-liposome oral tablet are further disclosed. The formulation delivery system may be configured as any one of a pro-liposome oral tablet, sublingual tablet, caplet, capsule and aerosol.

Abstract: Methods and kits for performing genetic analyses of biological samples to assess predisposition for and/or to stratify risk Reward Deficiency Syndrome (RDS) behavior, including various addictive and/or compulsive behaviors, are described. The methods and kits of the invention use different nucleic acid probes to determine if a human subject's genome contains one or more alleles for one or more genes implicated in RDS.

Abstract: A new class of therapeutic neuro-electro-adaptive devices for delivering cranial electrotherapy (NEAT) to patients for the treatment of various diseases and disorders, including those involving Reward Deficiency Syndrome (RDS), are described, as are various methods for using such devices, for example, to treat RDS behaviors.

Abstract: The present invention provides a proprietary compositions and systems to modulate genetic and metabolomic contributing factors affecting disease diagnosis, stratification, and prognosis, as well as the metabolism, efficacy and/or toxicity associated with specific vitamins, minerals, herbal supplements, homeopathic ingredients, and other ingredients for the purposes of customizing a subject's nutritional supplement formulation to optimize specific health outcomes. Specific to this invention the utilization of certain known polymorphic genes associated with Substance Use Disorder (SUD) are analyzed to target certain genetic anomalies that lead to a high risk and predisposition to SUD. The genotypic patterns are then utilized to provide certain nutritional customized solutions especially related to the attenuation of aberrant abuse of physician prescribed narcotic pain medication across all pain conditions.

Abstract: Methods and apparatus to restore central and peripheral disorders/dysfunction caused by edema, ischemia, and nitric oxide (NO) deficiency and to improve or facilitate muscle performance (e.g. endurance and recovery) by utilizing a device which stimulates cell initiated NO activation, promotes interstitial protein clearance, and induces angiogenesis. By use of these methods and apparatus, it is possible to treat a number of disorders/diseases caused by a deficiency of nitric oxide, a lack of proper circulation and vascularity, a build up of proteins and increased tissue water content due to injury; and to improve or facilitate muscle performance (e.g., muscle endurance and muscle recovery.

Abstract: Methods and apparatus to restore central and peripheral disorders/dysfunction caused by edema, ischemia, and nitric oxide (NO) deficiency and to improve or facilitate muscle performance (e.g. endurance and recovery) by utilizing a device which stimulates cell initiated NO activation, promotes interstitial protein clearance, and induces angiogenesis. By use of these methods and apparatus, it is possible to treat a number of disorders/diseases caused by a deficiency of nitric oxide, a lack of proper circulation and vascularity, a build up of proteins and increased tissue water content due to injury; and to improve or facilitate muscle performance (e.g., muscle endurance and muscle recovery.