Patents by Inventor William J. Lacey
William J. Lacey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10155924Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.Type: GrantFiled: June 10, 2016Date of Patent: December 18, 2018Assignee: Corning IncorporatedInventors: Amy W Cai, William J Lacey, Michael S Shanler
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Patent number: 10053661Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.Type: GrantFiled: June 26, 2014Date of Patent: August 21, 2018Assignee: Corning IncorporatedInventors: William J. Lacey, Michael S. Shanler, Amy W. Cai
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Patent number: 9976114Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.Type: GrantFiled: November 14, 2014Date of Patent: May 22, 2018Assignee: Corning IncorporatedInventors: Amy W Cai, William J Lacey, Michael S Shanler
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Publication number: 20160326479Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.Type: ApplicationFiled: June 26, 2014Publication date: November 10, 2016Inventors: William J. Lacey, Michael S. Shanler, Amy W. Cai
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Publication number: 20160281042Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.Type: ApplicationFiled: June 10, 2016Publication date: September 29, 2016Inventors: Amy W. Cai, William J. Lacey, Michael S. Shanler
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Publication number: 20150072407Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.Type: ApplicationFiled: November 14, 2014Publication date: March 12, 2015Inventors: AMY W. CAI, William J. Lacey, Michael S. Shanler
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Publication number: 20140308740Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom, a top, a tubular neck, and, one or more shelves. The first shelf adjoins the top with the first shelf being located intermediate the bottom and the top. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells with the enclosed volume being accessible by the opening in the tubular neck. Advantageously, this vessel provides high volume cell culture in a manner that increases efficiency and reduces the cost of culturing cells.Type: ApplicationFiled: June 26, 2014Publication date: October 16, 2014Inventors: William J. Lacey, Michael S. Shanler, Amy W. Cai
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Patent number: 8778669Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom including a base with an upwardly extending wall at least partially bounding the base of the bottom; a top including a base with a downwardly extending wall at least partially bounding the base of the top; a tubular neck with an opening defined therein; and, one or more shelves, wherein, each shelf includes a base with an upwardly extending wall at least partially bounding the base of the shelf. The upwardly extending wall of a first shelf adjoins the downwardly extending wall of the top with the first shelf being located intermediate the bottom and the top. The base of each of the shelves having at least one aperture formed therein. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells. The tubular neck extends from the vessel with the enclosed volume being accessible by the opening in the tubular neck.Type: GrantFiled: July 21, 2010Date of Patent: July 15, 2014Assignee: Corning IncorporatedInventors: William J. Lacey, Michael S. Shanler, Amy W. Cai
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Publication number: 20110020923Abstract: The present invention discloses a vessel for culturing cells which includes: a bottom including a base with an upwardly extending wall at least partially bounding the base of the bottom; a top including a base with a downwardly extending wall at least partially bounding the base of the top; a tubular neck with an opening defined therein; and, one or more shelves, wherein, each shelf includes a base with an upwardly extending wall at least partially bounding the base of the shelf. The upwardly extending wall of a first shelf adjoins the downwardly extending wall of the top with the first shelf being located intermediate the bottom and the top. The base of each of the shelves having at least one aperture formed therein. The bottom, the top and the one or more shelves collectively define an enclosed volume for culturing cells. The tubular neck extends from the vessel with the enclosed volume being accessible by the opening in the tubular neck.Type: ApplicationFiled: July 21, 2010Publication date: January 27, 2011Applicant: BECTON, DICKINSON AND COMPANYInventors: WILLIAM J. LACEY, MICHAEL S. SHANLER, AMY W. CAI
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Publication number: 20100119418Abstract: A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.Type: ApplicationFiled: January 20, 2010Publication date: May 13, 2010Inventors: James G. Clements, Michael Curtis, Paul E. Gagnon, William J. Lacey, Gregory R. Martin, David M. Root, Allison J. Tanner
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Patent number: 7674346Abstract: A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.Type: GrantFiled: October 15, 2004Date of Patent: March 9, 2010Assignee: Corning IncorporatedInventors: James G. Clements, Michael Curtis, Paul E. Gagnon, William J. Lacey, Gregory R. Martin, David M. Root, Allison J. Tanner
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Patent number: 7078228Abstract: A stackable flask for the culturing of cells is disclosed. The cell culture chamber is defined by a top plate and a rigid bottom tray of substantially rectangular shape connected by side and end walls, the body of the flask has imparted therein a gas permeable membrane that will allow the free flow of gases between the cell culture chamber and the external environment. The flask body also includes a sealed septum that will allow access to the cell growth chamber by means of a needle or cannula. The size of the flask and location of an optional neck and cap section allows for flask manipulation by standard automated assay equipment, making the flask ideal for high throughput applications.Type: GrantFiled: December 31, 2003Date of Patent: July 18, 2006Assignee: Corning IncorporatedInventors: William J. Lacey, John A. Ryan, Laurence M. Vaughan, Joseph C. Wall, Kathy M. Youngbear
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Patent number: 6943009Abstract: A high-throughput cell or tissue culture apparatus, which is configurable to an industry-standard well plate format, is provided. The apparatus comprises a number of vessels, which may be suspended in wells of a plate. Each vessel has at least one sidewall defining a first opening and a second opening, each of predetermined cross-sectional area. The second opening has an inner cross-sectional area greater than either the inner cross-sectional area of the first opening or a cross-sectional area in a horizontal plane between the first and second openings. A relatively large substrate area is provided in each vessel for supporting tissue cultures in a fluid medium.Type: GrantFiled: May 15, 2002Date of Patent: September 13, 2005Assignee: Corning IncorporatedInventors: William J. Lacey, Gregory Mathus, David M. Root, John A. Ryan
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Publication number: 20030215940Abstract: A high-throughput cell or tissue culture apparatus, which is configurable to an industry-standard well plate format, is provided. The apparatus comprises a number of vessels, which may be suspended in wells of a plate. Each vessel has at least one sidewall defining a first opening and a second opening, each of predetermined cross-sectional area. The second opening has an inner cross-sectional area greater than either the inner cross-sectional area of the first opening or a cross-sectional area in a horizontal plane between the first and second openings. A relatively large substrate area is provided in each vessel for supporting tissue cultures in a fluid medium.Type: ApplicationFiled: May 15, 2002Publication date: November 20, 2003Inventors: William J. Lacey, Gregory Mathus, David M. Root, John A. Ryan
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Patent number: 6514402Abstract: The present invention includes a method and sensor that is easy to assemble and can operate to effectively detect an air borne or exogenously introduced analyte. In one embodiment, the assembled sensor includes a top cap capable of receiving a first electrolyte and a bottom cap capable of receiving a second electrolyte. The assembled sensor also includes a flexible boot that holds together the top cap, the bottom cap and a membrane. The membrane is located between the first electrolyte and the second electrolyte and enables an electrical device to detect an analyte (e.g., hazardous chemical) which originally entered the sensor through a passage in the top cap and interacted with the membrane.Type: GrantFiled: December 6, 2000Date of Patent: February 4, 2003Assignee: Corning IncorporatedInventors: Narayan V. Iyer, William J. Lacey, David M. Root
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Publication number: 20020022219Abstract: A method of manufacture and assembly of multiwell plates employing targeted radiation at an interface in order to achieve bonding is disclosed. The method accommodates glass and polymer attachment as well as polymer to polymer attachment. Resultant plates have unique flatness and optical properties.Type: ApplicationFiled: April 18, 2001Publication date: February 21, 2002Inventors: James G. Clements, Michael Curtis, Paul E. Gagnon, William J. Lacey, Gregory R. Martin, David M. Root, Allison J. Tanner
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Publication number: 20010040103Abstract: The present invention includes a method and sensor that is easy to assemble and can operate to effectively detect an air borne or exogenously introduced analyte. In one embodiment, the assembled sensor includes a top cap capable of receiving a first electrolyte and a bottom cap capable of receiving a second electrolyte. The assembled sensor also includes a flexible boot that holds together the top cap, the bottom cap and a biosensor. The biosensor is operational when it is located between the first electrolyte and the second electrolyte and enables an electrical device to detect an analyte (e.g., hazardous chemical) that enters the sensor through a passage in the top cap. In particular, the electrical device can apply a voltage to the first electrolyte, the biosensor and the second electrolyte, and then detect the presence of an analyte interacting with the biosensor by detecting a change in the electrical characteristic of the biosensor caused by the presence of the analyte.Type: ApplicationFiled: December 6, 2000Publication date: November 15, 2001Inventors: Narayan V. Iyer, William J. Lacey, David M. Root
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Patent number: 6103169Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate.Type: GrantFiled: September 15, 1998Date of Patent: August 15, 2000Assignee: Corning IncorporatedInventors: Gregory Mathus, Paul M. Szlosek, William J. Lacey
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Patent number: 5858309Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate.Type: GrantFiled: March 22, 1996Date of Patent: January 12, 1999Assignee: Corning IncorporatedInventors: Gregory Mathus, Paul M. Szlosek, William J. Lacey
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Patent number: RE38214Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate.Type: GrantFiled: January 12, 2001Date of Patent: August 12, 2003Assignee: Corning IncorporatedInventors: William J. Lacey, Gregory Mathus, Paul M. Szlosek