Patents by Inventor William J. Marsheck

William J. Marsheck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SNAKE VENOM COMPOSITIONS AND METHODS OF USE
    Publication number: 20080279958
    Abstract: The invention relates to the discovery that formulations of Lachesis venom decrease circulating TNF-? levels in mammals including humans, and that administration of Lachesis venom-containing formulations to mammals suffering from sepsis, parasitic infection, cisplatin nephrotoxicity, rheumatoid arthritis, cancer and AIDS mitigates symptoms associated with these conditions.
    Type: Application
    Filed: May 9, 2008
    Publication date: November 13, 2008
    Inventors: William H. Reeves, Ruben P. Laguens, William J. Marsheck, Martin Laguens
  • Microbial process for 9.alpha.-hydroxylation of steroids
    Patent number: 4397947
    Abstract: Valuable 9.alpha.-hydroxy steroids are prepared via microbial enzymatic oxidation (MEO) by conventional fermentation means, without the need for a .DELTA..sup.1 dehydrogenation inhibitor, utilizing novel microorganism Nocardia canicruria ATCC 31548. Also disclosed is a novel method using any .DELTA..sup.1 dehydrogenase producing organism and a novel bio-reactor technique means for preparing said steroids.
    Type: Grant
    Filed: June 12, 1981
    Date of Patent: August 9, 1983
    Assignee: G. D. Searle & Co.
    Inventors: William J. Marsheck, James Jiu, Ping T. Wang
  • Process of preparing 3-oxo-pregna-4,17(20)-dien-21-carboxylic acid and esters with mycobacterium
    Patent number: 4032408
    Abstract: The present invention is concerned with the preparation of 3-oxo-pregna-4,17(20)-dien-21-carboxylic acid and esters thereof by the microbial degradation of fucosterol, cholesterol, stigmasterol, campesterol or sitosterol with Mycobacterium sp. NRRL B-8054. The compounds of the present invention are useful antispasmodic agents and are also active against influenza virus.
    Type: Grant
    Filed: August 4, 1976
    Date of Patent: June 28, 1977
    Assignee: G. D. Searle & Co.
    Inventors: James Jiu, William J. Marsheck
  • 3-Oxo-pregna-4,17(20)-dien-20-carboxylic acid and esters
    Patent number: 3994933
    Abstract: The present invention is concerned with the preparation of 3-oxo-pregna-4,17(20)-dien-21-carboxylic acid and esters thereof by the microbial degradation of fucosterol, cholesterol, stigmasterol, campesterol or sitosterol with Mycobacterium sp. NRRL B-8054. The compounds of the present invention are useful antispasmodic agents and are also active against influenza virus.
    Type: Grant
    Filed: April 30, 1975
    Date of Patent: November 30, 1976
    Assignee: G. D. Searle & Co.
    Inventors: James Jiu, William J. Marsheck
  • 6.beta.,17-Dihydroxy-7.alpha.-(lower alkoxy)carbonyl-3-oxo-17.alpha.-pregn-4-ene-21-carboxylic acid .gamma.-lactones and congeners
    Patent number: 3972871
    Abstract: The preparation and valuable biological properties - especially diuretic activity - of 6.beta.,17-dihydroxy-7.alpha.-(lower alkoxy)carbonyl-3-oxo-17.alpha.-pregn-4-ene-21-carboxylic acid .gamma.-lactones and the corresponding hydroxy acids and salts thereof are disclosed.
    Type: Grant
    Filed: September 22, 1975
    Date of Patent: August 3, 1976
    Assignee: G. D. Searle & Co.
    Inventors: Aziz Karim, William J. Marsheck, Richard M. Weier