Patents by Inventor William J. Merrell

William J. Merrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170065630
    Abstract: Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of a least one microencapsulated nitrite salt and an activating volume of an aqueous acidified gel that has sufficient acidity to convert the nitrite salt to a nitric oxide (NO) and further provides a reducing property that retains the NO in bioactive form
    Type: Application
    Filed: September 17, 2016
    Publication date: March 9, 2017
    Inventors: Cheng-Shing Chen, Ferid Murad, Kenneth A. Smith, WIlliam A. Seitz, William J. Merrell, Alexandru T. Balaban
  • Patent number: 9445996
    Abstract: Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of a least one microencapsulated nitrite salt and an activating volume of an aqueous acidified gel that has sufficient acidity to convert the nitrite salt to a nitric oxide (NO) and further provides a reducing property that retains the NO in bioactive form.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: September 20, 2016
    Assignee: NIOXX LLC
    Inventors: Cheng-Shing Chen, Ferid Murad, Kenneth A Smith, William A Seitz, William J Merrell, Alexandru T Balaban
  • Patent number: 8980331
    Abstract: Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of water-soluble chemical reactants microencapsulated in polymer matrices. In some applications the microencapsulated reactants are introduced in an aqueous gel, and in other applications they are introduced to the area of therapy either directly or in a medical device such as a therapeutic pad or dressing. In some applications, the microencapsulated chemical precursors are maintained in close physical proximity to one another in a limited volume, and using a limited amount of solvent residing within that same volume to extract and process the chemical precursors to form NO.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: March 17, 2015
    Assignee: Nioxx LLC
    Inventors: Cheng-Shing Chen, Ferid Murad, Kenneth A Smith, William A Seitz, William J Merrell, Alexandru T Balaban
  • Publication number: 20140056963
    Abstract: Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of a least one microencapsulated nitrite salt and an activating volume of an aqueous acidified gel that has sufficient acidity to convert the nitrite salt to a nitric oxide (NO) and further provides a reducing property that retains the NO in bioactive form
    Type: Application
    Filed: August 16, 2013
    Publication date: February 27, 2014
    Applicant: NIOXX LLC
    Inventors: Cheng-Shing Chen, Ferid Murad, Kenneth A. Smith, WIlliam A. Seitz, William J. Merrell, Alexandru T. Balaban
  • Publication number: 20140056957
    Abstract: Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of water-soluble chemical reactants microencapsulated in polymer matrices. In some applications the microencapsulated reactants are introduced in an aqueous gel, and in other applications they are introduced to the area of therapy either directly or in a medical device such as a therapeutic pad or dressing. In some applications, the microencapsulated chemical precursors are maintained in close physical proximity to one another in a limited volume, and using a limited amount of solvent residing within that same volume to extract and process the chemical precursors to form NO.
    Type: Application
    Filed: August 16, 2013
    Publication date: February 27, 2014
    Applicant: NIOXX LLC
    Inventors: Cheng-Shing Chen, Ferid Murad, Kenneth A. Smith, WIlliam A. Seitz, William J. Merrell, Alexandru T. Balaban