Patents by Inventor William J. Novick
William J. Novick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6420374Abstract: A family of compounds effective in suppressing lymphocyte activation is comprised of 7-(oxoalkyl)1,3-dialkyl xanthines, other than denbufylline, of the formula in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group.Type: GrantFiled: November 6, 1996Date of Patent: July 16, 2002Assignee: Fred Hutchinson Cancer Research CenterInventors: James A. Bianco, Jack W. Singer, William J. Novick, Jr.
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Patent number: 5272153Abstract: A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. Another family of effective compounds is identified as ##STR2## The inhibition of IL-1, TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.Type: GrantFiled: July 2, 1992Date of Patent: December 21, 1993Assignees: Hoechst-Roussel Pharmaceuticals, Inc., University of Virginia Alumni Patents FoundationInventors: Gerald L. Mandell, Gail W. Sullivan, William J. Novick
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Patent number: 5196430Abstract: A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of straight-chain or branch alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. Another family of effective compounds is identified as ##STR2## The inhibition of IL-1, TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.Type: GrantFiled: September 18, 1991Date of Patent: March 23, 1993Assignees: Hoechst-Roussel Pharmaceuticals Inc., University of Virginia Alumni Patents FoundationInventors: Gerald L. Mandell, Gail W. Sullivan, William J. Novick
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Patent number: 5196429Abstract: A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. Another family of effective compounds is identified as ##STR2## The inhibition of IL-1, TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.Type: GrantFiled: July 30, 1991Date of Patent: March 23, 1993Assignees: Hoechst-Roussel Pharmaceuticals Inc., University of VA Alumni Patents FoundationInventors: Gerald L. Mandell, Gail W. Sullivan, William J. Novick
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Patent number: 5096906Abstract: A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. Another family of effective compounds is identified as ##STR2## The inhibition of IL-1, TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.Type: GrantFiled: December 5, 1990Date of Patent: March 17, 1992Assignees: University of Virginia Alumni Patents Foundation, Hoechst Roussel Pharmaceuticals Inc.Inventors: Gerald L. Mandell, Gail W. Sullivan, William J. Novick
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Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside
Patent number: 5039666Abstract: This invention relates to an aminoglycoside composition having reduced nephrotoxicity induced by the aminoglycoside which comprises a selected aminoglycoside and a compound present in an effective amount selected from the group consisting of (a) at least one 7-(oxoalkyl)1,3-dialkyl xanthine of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are independently selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, straight-chain or branched chain alkoxyalkyl and hydroxyalkyl radicals; and A is a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group; (b) a compound of the formula ##STR2## wherein at least one of R.sub.3 and R.sub.4 is a branched hydroxyalkyl group of the formula ##STR3## with a tertiary alcohol function, which R.sub.6 stands for an alkyl group with 1 to 3 carbon atoms and n stands for a whole number from 2 to 5, the other R.sub.3 or R.sub.Type: GrantFiled: October 30, 1990Date of Patent: August 13, 1991Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventor: William J. Novick, Jr. -
Patent number: 4965271Abstract: A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. The inhibition of Il-1, TNF, and other cytokines in mammals is implicated in allerviation of a wide variety of disease conditions.Type: GrantFiled: December 11, 1987Date of Patent: October 23, 1990Assignees: Hoechst Roussel Pharmaceuticals, Inc., University of VirginiaInventors: Gerald L. Mandell, Gail W. Sullivan, William J. Novick
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Patent number: 4636507Abstract: A method of enhancing host defense mechanisms utilizing xanthines is disclosed.Type: GrantFiled: April 30, 1984Date of Patent: January 13, 1987Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Donald L. Kreutzer, William J. Novick, Jr., Michael P. Sheetz
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Patent number: 4082850Abstract: A method of treating dermal inflammation by topically administering to a patient an effective amount of a 6,11-dihydrodibenz[b,e]oxepinalkanoic acid, physiologically tolerable salt thereof, derivative thereof, or diacid precursor thereof is described.Type: GrantFiled: April 16, 1976Date of Patent: April 4, 1978Assignee: American Hoechst CorporationInventors: Howard B. Lassman, William J. Novick, Jr.
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Patent number: 4056624Abstract: A method of treating dermal inflammation by topically administering to a patient an effective amount of a condensed pyrrole bearing a N-phenyl substituent and compositions containing an aforesaid pyrrole are described.Type: GrantFiled: May 14, 1976Date of Patent: November 1, 1977Assignee: American Hoechst CorporationInventors: Howard B. Lassman, William J. Novick, Jr.
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Patent number: 3980787Abstract: Novel 3-phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives and a method of preparing the same are described. These compounds are useful as diuretic and antihypertensive agents.Type: GrantFiled: August 25, 1975Date of Patent: September 14, 1976Assignee: American Hoechst CorporationInventors: Solomon S. Klioze, William J. Novick, Jr.