Patents by Inventor William J. Novick, Jr.

William J. Novick, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of xanthines as immunosuppressants and to inhibit allograft reactions
    Patent number: 6420374
    Abstract: A family of compounds effective in suppressing lymphocyte activation is comprised of 7-(oxoalkyl)1,3-dialkyl xanthines, other than denbufylline, of the formula in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group.
    Type: Grant
    Filed: November 6, 1996
    Date of Patent: July 16, 2002
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: James A. Bianco, Jack W. Singer, William J. Novick, Jr.
  • Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside
    Patent number: 5039666
    Abstract: This invention relates to an aminoglycoside composition having reduced nephrotoxicity induced by the aminoglycoside which comprises a selected aminoglycoside and a compound present in an effective amount selected from the group consisting of (a) at least one 7-(oxoalkyl)1,3-dialkyl xanthine of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are independently selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, straight-chain or branched chain alkoxyalkyl and hydroxyalkyl radicals; and A is a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group; (b) a compound of the formula ##STR2## wherein at least one of R.sub.3 and R.sub.4 is a branched hydroxyalkyl group of the formula ##STR3## with a tertiary alcohol function, which R.sub.6 stands for an alkyl group with 1 to 3 carbon atoms and n stands for a whole number from 2 to 5, the other R.sub.3 or R.sub.
    Type: Grant
    Filed: October 30, 1990
    Date of Patent: August 13, 1991
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventor: William J. Novick, Jr.
  • Host defense mechanism enhancement
    Patent number: 4636507
    Abstract: A method of enhancing host defense mechanisms utilizing xanthines is disclosed.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: January 13, 1987
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Donald L. Kreutzer, William J. Novick, Jr., Michael P. Sheetz
  • Method of treating dermal inflammations
    Patent number: 4082850
    Abstract: A method of treating dermal inflammation by topically administering to a patient an effective amount of a 6,11-dihydrodibenz[b,e]oxepinalkanoic acid, physiologically tolerable salt thereof, derivative thereof, or diacid precursor thereof is described.
    Type: Grant
    Filed: April 16, 1976
    Date of Patent: April 4, 1978
    Assignee: American Hoechst Corporation
    Inventors: Howard B. Lassman, William J. Novick, Jr.
  • Method of treating dermal inflammation
    Patent number: 4056624
    Abstract: A method of treating dermal inflammation by topically administering to a patient an effective amount of a condensed pyrrole bearing a N-phenyl substituent and compositions containing an aforesaid pyrrole are described.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: November 1, 1977
    Assignee: American Hoechst Corporation
    Inventors: Howard B. Lassman, William J. Novick, Jr.
  • 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives
    Patent number: 3980787
    Abstract: Novel 3-phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives and a method of preparing the same are described. These compounds are useful as diuretic and antihypertensive agents.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: September 14, 1976
    Assignee: American Hoechst Corporation
    Inventors: Solomon S. Klioze, William J. Novick, Jr.