Patents by Inventor William J. Paleveda

William J. Paleveda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclicdicarboximides
    Patent number: 4173646
    Abstract: Tricyclicdicarboximides representatively prepared by the Diels-Alder condensation of a cyclic diene such as cycloheptatriene, cyclooctatetraene and the like with a dienophile such as substituted N-phenylmaleimide and the like are disclosed having pharmaceutical utility as minor tranquilizers and anti-convulsants. Also disclosed are processes for the preparation of such tricyclicdicarboximides; pharmaceutical compositions comprising such compounds and their salt; ester and amide or derivatives; and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: September 28, 1978
    Date of Patent: November 6, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, William J. Paleveda, Jr.
  • Somatostatin analogs
    Patent number: 4162248
    Abstract: Somatostatin analogs having the structural formula:Cyclo[(X).sub.j -(A).sub.k -(B).sub.1 -Phe-Phe-(D- or L-)Trp-Lys-Thr-Phe-Thr-(C).sub.m ]WhereinX is ##STR1## and n=0 to 4; A is Lys, (.epsilon.-INOC) Lysine;B is Asn, Ala, .alpha.-aminobutyric acid;C is Ser, Gly;J, k, l and m are 0 to 1; with the proviso that j, k, l, and m are not all 1 and not all 0,Wherein the ring formed by the peptide backbone contains 24 to 33 atoms and the pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, decreasing gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
    Type: Grant
    Filed: April 7, 1978
    Date of Patent: July 24, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Robert G. Strachan, William J. Paleveda, Daniel F. Veber, Frederick W. Holly
  • Somatostatin analogs
    Patent number: 4161521
    Abstract: Somatostatin analogs having the structural formula: ##STR1## are prepared by controlled stepwise procedures starting with individual amino acid components. These peptides have the property of lowering blood glucose, inhibiting gastric secretion, inhibiting growth hormone release and inhibiting glucagon release in humans and animals.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: July 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Frederick W. Holly, Robert G. Strachan, William J. Paleveda, Ruth F. Nutt, Ralph F. Hirschmann
  • N-(Benzoxazolinyl-2-one)-tricyclic dicarboximides
    Patent number: 4132799
    Abstract: Tricyclicdicarboximides representatively prepared by the Diels-Alder condensation of a cyclic diene such as cycloheptatriene, cyclooctatetraene and the like with a dienophile such as substituted N-phenylmaleimide and the like are disclosed having pharmaceutical utility as minor tranquilizers and anti-convulsants. Also disclosed are processes for the preparation of such tricyclicdicarboximides; pharmaceutical compositions comprising such compounds and their salt, ester and amide derivatives; and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: September 8, 1977
    Date of Patent: January 2, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, William J. Paleveda, Jr.
  • Process for preparing somatostatin analog
    Patent number: 4130554
    Abstract: Somatostatin analog, hereinafter designated des(Ala.sup.1 -Gly.sup.2)desaminocys.sup.3 -somatostatin, having the structure: ##STR1## is prepared by controlled stepwise procedures starting with individual amino acid components. This peptide has the property of lowering blood glucose, inhibiting gastric secretion and inhibiting growth hormone release in humans and animals.
    Type: Grant
    Filed: April 8, 1975
    Date of Patent: December 19, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Frederick W. Holly, William J. Paleveda, Robert G. Strachan, Daniel F. Veber
  • Tricyclicdicarboximides
    Patent number: 4061763
    Abstract: Tricyclicdicarboximides representatively prepared by the Diels-Alder condensation of a cyclic diene such as cycloheptatriene, cyclooctatetraene and the like with a dienophile such as substituted N-phenylmaleimide and the like are disclosed having pharmaceutical utility as minor tranquilizers and anti-convulsants. Also disclosed are processes for the preparation of such tricyclicdicarboximides; pharmaceutical compositions comprising such compounds and their salt, ester and amide derivatives, and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: August 12, 1976
    Date of Patent: December 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, William J. Paleveda, Jr.
  • N-(pyrimidinyl)-tricyclo[3(or 4).2.2.0.sup.2,4(or 5) ]-non (or dec)ene-dicarboximides
    Patent number: 4006233
    Abstract: Tricyclicdicarboximides representatively prepared by the Diels-Alder condensation of a cyclic diene such as cycloheptatriene, cyclooctatetraene and the like with a dienophile such as substituted N-phenylmaleimide and the like are disclosed having pharmaceutical utility as minor tranquilizers and anti-convulsants. Also disclosed are processes for the preparation of such tricyclicdicarboximides; pharmaceutical compositions comprising such compounds and their salt, ester and amide derivatives; and methods of treatment comprising administering such compounds and compositions.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: February 1, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Kenneth L. Shepard, William J. Paleveda, Jr.