Patents by Inventor William J. Pavan

William J. Pavan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Viral gene therapy as treatment for cholesterol storage disease or disorder
    Patent number: 12201658
    Abstract: Provided herein are compositions and methods for the viral gene therapy (e.g., AAV-directed gene therapy) of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: January 21, 2025
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Charles P. Venditti, Randy Chandler, William J. Pavan
  • CODON-OPTIMIZED HUMAN NPC1 GENES FOR THE TREATMENT OF NIEMANN-PICK TYPE C1 DEFICIENCY AND RELATED CONDITIONS
    Publication number: 20240409948
    Abstract: The present disclosure provides compositions for viral gene therapy, e.g. Adeno-Associated virus-directed gene therapy, and methods of using the same for the treatment and/or prevention of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C.
    Type: Application
    Filed: August 27, 2024
    Publication date: December 12, 2024
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Charles P. Venditti, William J. Pavan, Randy J. Chandler
  • Codon-optimized human NPC1 genes for the treatment of Niemann-Pick type C1 deficiency and related conditions
    Patent number: 12116577
    Abstract: The present disclosure provides compositions for viral gene therapy, e.g. Adeno-Associated virus-directed gene therapy, and methods of using the same for the treatment and/or prevention of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: October 15, 2024
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Charles P. Venditti, William J. Pavan, Randy J. Chandler
  • VIRAL GENE THERAPY AS TREATMENT FOR CHOLESTEROL STORAGE DISEASE OR DISORDER
    Publication number: 20210113635
    Abstract: Provided herein are compositions and methods for the viral gene therapy (e.g.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 22, 2021
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Charles P. Venditti, Randy Chandler, William J. Pavan
  • CODON-OPTIMIZED HUMAN NPC1 GENES FOR THE TREATMENT OF NIEMANN-PICK TYPE C1 DEFICIENCY AND RELATED CONDITIONS
    Publication number: 20200377906
    Abstract: The present disclosure provides compositions for viral gene therapy, e.g. Adeno-Associated virus-directed gene therapy, and methods of using the same for the treatment and/or prevention of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 3, 2020
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Charles P. Venditti, William J. Pavan, Randy J. Chandler
  • Compositions and methods for predicting age of onset of a lysosomal storage disease or a disease associated with a lysosomal defect
    Patent number: 9983200
    Abstract: The present invention features diagnostic compositions and methods for predicting the age of onset of a lysosomal storage disease or a disease associated with a lysosomal defect in subject.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 29, 2018
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: William J. Pavan, Jorge L. Rodriguez, Denise M. Larson, Forbes D. Porter, III
  • VIRAL GENE THERAPY AS TREATMENT FOR CHOLESTEROL STORAGE DISEASE OR DISORDER
    Publication number: 20180104289
    Abstract: Provided herein are compositions and methods for the viral gene therapy (e.g., AAV-directed gene therapy) of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C.
    Type: Application
    Filed: April 7, 2016
    Publication date: April 19, 2018
    Applicants: Services
    Inventors: Charles P. Venditti, Randy Chandler, William J. Pavan
  • COMPOSITIONS AND METHODS FOR PREDICTING AGE OF ONSET OF A LYSOSOMAL STORAGE DISEASE OR A DISEASE ASSOCIATED WITH A LYSOSOMAL DEFECT
    Publication number: 20160025712
    Abstract: The present invention features diagnostic compositions and methods for predicting the age of onset of a lysosomal storage disease or a disease associated with a lysosomal defect in subject.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: William J. Pavan, Jorge L. Rodriguez, Denise M. Larson, Forbes D. Porter, III
  • IDENTIFICATION OF TWO NOVEL BIOMARKERS FOR NIEMANN-PICK DISEASE TYPE C
    Publication number: 20140370521
    Abstract: This invention provides novel biomarkers for Niemann-Pick disease, type C (NPC). In an exemplary embodiment, the invention provides methods for identifying a subject as having NPC. In embodiments, the methods involve detecting the level of biomarker selected from the group comprising i) galectin-3 (LGALS3); ii) cathepsin D (CTSD); iii) LGALS3 and CTSD; and iv) LGALS3 and/or CTSD in combination at least one additional NPC associated biomarker in a sample obtained from the subject. In embodiments, the methods involve comparing the level of biomarker to a reference.
    Type: Application
    Filed: December 14, 2012
    Publication date: December 18, 2014
    Inventors: Forbes D. Porter, III, Celine V. M. Cluzeau, Dawn E. Watkins-Chow, Christopher A. Wassif, William J. Pavan
  • Genes for Niemann-Pick type C disease
    Patent number: 7045675
    Abstract: A gene for type C Niemann-Pick disease (NP-C) is disclosed, along with the amino acid sequence of the encoded peptide. Applications which are made possible by the present invention include detection of NP-C carriers and diagnosis of NP-C sufferers. The murine ortholog of the human gene is also disclosed.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: May 16, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Eugene D Carstea, Danilo A. Tagle, Jill A. Morris, Peter G. Pentchev, William J. Pavan, Melissa A. Ashlock, Stacie K. Loftus, Jessie Gu
  • Genes for Niemann-Pick type C disease
    Publication number: 20030092038
    Abstract: A gene for type C Niemann-Pick disease (NP-C) is disclosed, along with the amino acid sequence of the encoded peptide. Applications which are made possible by the present invention include detection of NP-C carriers and diagnosis of NP-C sufferers. The murine ortholog of the human gene is also disclosed.
    Type: Application
    Filed: July 29, 2002
    Publication date: May 15, 2003
    Applicant: The Govt. of the USA, as represented by the Secretary of the Dept. of Health & Human Services
    Inventors: Eugene D. Carstea, Danilo A. Tagle, Jill A. Morris, Peter G. Pentchev, William J. Pavan, Melissa A. Ashlock, Stacie K. Loftus, Jessie Gu
  • Genes for Niemann-Pick type C disease
    Patent number: 6426198
    Abstract: A gene for type C Niemann-Pick disease (NP-C) is disclosed, along with the amino acid sequence of the encoded peptide. Applications which are made possible by the present invention include detection of NP-C carriers and diagnosis of NP-C sufferers. The murine ortholog of the human gene is also disclosed.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: July 30, 2002
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Eugene D. Carstea, Danilo A. Tagle, Jill A. Morris, Peter G. Pentchev, William J. Pavan, Melissa A. Ashlock, Stacie K. Loftus, Jessie Gu