Patents by Inventor William J. Pitts

William J. Pitts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED HETEROCYCLIC COMPOUNDS
    Publication number: 20120022041
    Abstract: Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein Q is R1 is cycloalkyl, heteroaryl, or heterocyclyl, each optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, —OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as vascular disease and autoimmune diseases.
    Type: Application
    Filed: January 22, 2010
    Publication date: January 26, 2012
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: William J. Pitts, Alaric J. Dyckman, Steven H. Spergel, Scott Hunter Watterson
  • SUBSTITUTED ISOXAZOLE COMPOUNDS
    Publication number: 20110300165
    Abstract: Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein Q is R1 is alkyl or aryl, said aryl optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, —OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: January 22, 2010
    Publication date: December 8, 2011
    Applicant: The Board of TRustees of the University of Illinoi University of Illinios
    Inventors: Scott Hunter Watterson, Alaric J. Dyckman, William J. Pitts, Steven H. Spergel
  • SUBSTITUTED PYRAZOLE COMPOUNDS
    Publication number: 20110275610
    Abstract: Disclosed are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: n is zero or an integer selected from 1 through 4; R1 is cycloalkyl, aryl, heteroaryl, or heterocyclyl, each optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, benzyl, —OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Application
    Filed: January 22, 2010
    Publication date: November 10, 2011
    Inventors: Alaric J. Dyckman, William J. Pitts, Scott Hunter Watterson
  • FUSED HETEROCYCLIC COMPOUNDS AND USES THEREOF
    Publication number: 20110230468
    Abstract: Fused heterocylic compounds of the following Formula wherein R1, R2, R5, Z, J1 and J2 are described herein, and analogs thereof are provided which are useful in treating leukocyte activation-associated disorders.
    Type: Application
    Filed: June 1, 2011
    Publication date: September 22, 2011
    Inventors: Joseph Barbosa, William J. Pitts, Junqing Guo
  • Fused heterocyclic compounds and use thereof
    Patent number: 7981881
    Abstract: Fused heterocylic compounds of the following Formula wherein R1, R2, R5, Z, J1 and J2 are described herein, and analogs thereof are provided which are useful in treating leukocyte activation-associated disorders.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: July 19, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Joseph Barbosa, William J. Pitts, Junqing Guo
  • 1,6-DIHYDRO-1,3,5,6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
    Publication number: 20100210629
    Abstract: The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Application
    Filed: April 23, 2010
    Publication date: August 19, 2010
    Inventors: William J. Pitts, James Kempson, Junqing Guo, Jagabandhu Das, Charles M. Langevine, Steven H. Spergel, Scott Hunter Watterson
  • 1,6-dihydro-1,3,5,6-tetraaza--indacene based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7737279
    Abstract: The present invention provides for tricyclic compounds having the formula (I), wherein R1, R2, R5, R6, R7, and R8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: May 8, 2006
    Date of Patent: June 15, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: William J. Pitts, James Kempson, Junqing Guo, Jagabandhu Das, Charles M. Langevine, Steven H. Spergel, Scott Hunter Watterson
  • 1-imidazo[4,5-]thieno[3,2-]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7683171
    Abstract: The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I), wherein R1, R2, R5, R6 and R7 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: March 23, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: William J. Pitts, Jagabandhu Das, Yuping Qiu, Steven H. Spergel
  • Pyrido[2,3-D]pyrimidine inhibitors of phosphodiesterase (PDE) 7
    Patent number: 7601836
    Abstract: Pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors are provided which are useful in treating T-cell mediated diseases, said inhibitors include: (i) 2-[[4-[[[4-(Aminosulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-4-methyl-5-thiazolecarboxylic acid, ethyl ester; and 4-Methyl-2-[[4-[[[4-(methylsulfonyl)phenyl]methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]amino]-5-thiazolecarboxylic acid, ethyl ester; or (ii) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt of (i).
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: October 13, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: William J. Pitts, Joseph Barbosa
  • Barbituric acid derivatives as inhibitors of TNF-? converting enzyme (TACE) and/or matrix metalloproteinases
    Patent number: 7595317
    Abstract: The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-? converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: September 29, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jingwu Duan, Bin Jiang, Lihua Chen, Zhonghui Lu, Joseph Barbosa, William J. Pitts
  • 8H-imidazo[4,5-D]thiazolo[4,5-B]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7557211
    Abstract: The present invention provides for thiazolopyridine-based tricyclic compounds having the formula (I), wherein R1, R2, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: July 7, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jagabandhu Das, James Kempson, William J. Pitts, Steven H. Spergel
  • Fused Heterocyclic Compounds and Use Thereof
    Publication number: 20080293650
    Abstract: Fused heterocylic compounds of the following Formula wherein R1, R2, R5, Z, J1 and J2 are described herein, and analogs thereof are provided which are useful in treating leukocyte activation-associated disorders.
    Type: Application
    Filed: March 18, 2008
    Publication date: November 27, 2008
    Inventors: Joseph Barbosa, William J. Pitts, Junqing Guo
  • Imidazo-fused oxazolo [4,5-]pyridine and imidazo-fused thiazolo[4,5-]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7456194
    Abstract: The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: November 25, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric Dyckman, William J. Pitts, Makonen Belema, Patrice Gill, James Kempson, Yuping Qiu, Claude Quesnelle, Steven H. Spergel, F. Christopher Zusi
  • Fused heterocyclic compounds and use thereof
    Patent number: 7384937
    Abstract: Fused heterocylic compounds of the following Formula wherein R1, R2, R5, Z, J1 and J2 are described herein, and analogs thereof are provided which are useful in treating leukocyte activation-associated disorders.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: June 10, 2008
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Joseph Barbosa, William J. Pitts, Junqing Guo
  • Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7329668
    Abstract: The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: February 12, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yuping Qiu, Makonen Belema, Xuejie Yang, Fred Christopher Zusi, William J. Pitts
  • Barbituric acid derivatives as inhibitors of TNF-? converting enzyme (TACE) and/or matrix metalloproteinases
    Patent number: 7294624
    Abstract: The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-? converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: November 13, 2007
    Assignee: Bristol Myers Squibb Company
    Inventors: Jingwu Duan, Bin Jiang, Lihua Chen, Zhonghui Lu, Joseph Barbosa, William J. Pitts
  • Imidazo-fused oxazolo[4,5-?]pyridine and imidazo-fused thiazolo[4,5-?]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
    Patent number: 7176214
    Abstract: The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: February 13, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: William J. Pitts, Makonen Belema, Patrice Gill, James Kempson, Yuping Qiu, Claude A. Quesnelle, Steven H. Spergel, Fred Christopher Zusi
  • Acyl guanidine compounds and use thereof
    Patent number: 7109224
    Abstract: Acyl guanidine compounds of the following Formula wherein R1, R2, R3, R4 and L are described herein, and pharmaceutical compositions thereof, are useful in treating leukocyte activation-associated disorders.
    Type: Grant
    Filed: November 6, 2003
    Date of Patent: September 19, 2006
    Assignee: Bristol-Myers Squibb Co.
    Inventors: James Kempson, William J. Pitts
  • Fused heterocyclic compounds and use thereof
    Patent number: 7105667
    Abstract: Fused heterocylic compounds of the following Formula wherein R1, R2, R5, Z, J1 and J2 are described herein which are useful in treating leukocyte activation-associated disorders.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: September 12, 2006
    Assignee: Bristol-Myers Squibb Co.
    Inventors: William J. Pitts, Joseph Barbosa, Junqing Guo
  • Quinazoline and pyrido[2,3-d]pyrimidine inhibitors of phosphodiesterase (PDE) 7
    Patent number: 7022849
    Abstract: Quinazoline and pyrido[2,3-d]pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula wherein R1, R2, L, Y1, Y2, Y3 and Z are as described herein, are provided which are useful in treating T-cell mediated diseases.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: April 4, 2006
    Assignee: Bristol-Myers Squibb Co.
    Inventors: William J. Pitts, Joseph Barbosa