Patents by Inventor William J. Placzek

William J. Placzek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MASS SPECTROMETRIC STANDARDS FOR HEMOGLOBIN BETA AND HEMOGLOBIN BETA SICKLE AND USES THEREOF
    Publication number: 20190346460
    Abstract: Provided herein are mass spectrometric standards for distinguishing hemoglobin beta (HBB) and hemoglobin beta sickle (HBS) and methods of using these standards to determine the amount of HBB relative to HBS in a sample.
    Type: Application
    Filed: December 19, 2017
    Publication date: November 14, 2019
    Inventors: William J. Placzek, Matthew B. Renfrow, Tim M. Townes, Robert H. Whitaker
  • SUMOylation assay and related reagents
    Patent number: 10167496
    Abstract: Provided herein and methods and kits for identifying inhibitors of SUMOylation. The provided methods include contacting a candidate agent with (i) a SUMO-conjugating peptide comprising an N-terminal linker and a detectable tag, and (ii) a SUMO comprising a metal complex, under conditions that allow binding between the SUMO-conjugating peptide and the SUMO, and detecting the detectable tag thereby determining the level of binding between the SUMO-conjugating peptide and SUMO. A reduced level of binding as compared to the level of binding in the absence of the candidate agent indicating the agent inhibits SUMOylation.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: January 1, 2019
    Assignee: The UAB Research Foundation
    Inventors: William J. Placzek, Mary-Ann Bjornsti, Christine M. Wright, Robert H. Whitaker
  • SUMOylation Assay and Related Reagents
    Publication number: 20170096698
    Abstract: Provided herein and methods and kits for identifying inhibitors of SUMOylation. The provided methods include contacting a candidate agent with (i) a SUMO-conjugating peptide comprising an N-terminal linker and a detectable tag, and (ii) a SUMO comprising a metal complex, under conditions that allow binding between the SUMO-conjugating peptide and the SUMO, and detecting the detectable tag thereby determining the level of binding between the SUMO-conjugating peptide and SUMO. A reduced level of binding as compared to the level of binding in the absence of the candidate agent indicating the agent inhibits SUMOylation.
    Type: Application
    Filed: October 3, 2016
    Publication date: April 6, 2017
    Applicant: The UAB Research Foundation
    Inventors: William J. Placzek, Mary-Ann Bjornsti, Christine M. Wright, Robert H. Whitaker