Abstract: The present invention relates to Bicycle toxin conjugates, methods for preparation, and methods of use for treating cancer.

Abstract: Systems and methods are disclosed herein that include providing a beverage dispensing machine with a cleaning system comprising a first water branch and a second water branch connected in fluid communication with a three-way valve, a cleaning supply connected in fluid communication with the second water branch via a pump, and a nozzle. The three-way valve may be operated in a “dispensing mode” to provide a flow of at least one of water and carbonated water through the first water branch and a flowpath of the three-way valve to the nozzle, and operated in a “cleaning mode” to provide a flow of a cleaner, and optionally a flow of at least one of water and carbonated water, through the second water branch and a secondary flowpath of the three-way valve to the nozzle to clean the nozzle and/or a drain of the beverage dispensing machine.

Abstract: Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

Abstract: A Data Over Cable Interface Specification (DOCSIS) node includes a first DOCSIS port and a second DOCSIS port. The node also includes a plurality of radio frequency (RF) ports. A plurality of client devices can be coupled to the RF ports. A RF switching network is coupled between the first DOCSIS port and the second DOCSIS port, and the plurality of RF ports. One or more control circuits can switch the RF switching network between at least a first state and a second state. The switching of the RF switching network allows the one or more control circuits to identify which client devices are coupled to which RF ports of the node.

Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Abstract: A motorized golf cart having a double wall thermoformed canopy fixedly connected to and supported over a chassis. The canopy has a bottom wall with fastener holes passing therethrough. A frame is provided to support the canopy having a front generally rectangular member and a rear inverted U-shaped member with apertures for passage of bolts therethrough. Blind fasteners are positioned in the bottom wall fastener holes and bolts passed through the frame apertures and into the blind fasteners to securely mount the canopy to the frame.

Abstract: A roof seaming machine has symmetrically arranged forming rolls and a reversible permanent magnet motor for operation of the machine in either a forward or reverse direction. Adjustable linkage connects the forming rolls with an articulated handle for moving the forming rolls relative to a drive wheel which propels the machine and which is adapted to be disposed on the opposite of a seam from the forming rolls. A reversible switch is connected to energize and deenergize the motor, and a directional switch safety guard is associated with the switch to limit its movement between an "off" position and either one of two "on" positions, depending upon the positioning of the guard.

Abstract: A compact and economical probe unit has projecting electrodes for sensing minute voltage variations at spaced apart locations on a persons skin or other surface. Internal circuits generate serial form digital signals indicative of the voltage variations for transmission to a personal computer where an electrocardiogram or other data presentation may be displayed. The probe includes a digital type of optical isolator through which the serial signals are transmitted, the output circuit of the isolator being energized by voltage taken from the computer and the input circuit being independently energized from a battery within the probe and thus there is no electrically conductive path between the computer and the electrodes. Among other uses, the probe enables unskilled persons to monitor their own heart activity as it is economical, safe and easily operated and makes use of a common computer for display rather than a costly electrocardiograph.

Abstract: The amount of building heating, cooling and daylighting is controlled by at least one pair of solar energy passing panels, with each panel of the pair of panels being exposed to a separate direction of sun incidence. A shutter-shade combination is associated with each pair of panels and the shutter is connected to the shade so that rectilinear movement of the shutter causes pivotal movement of the shade.

Abstract: A needle valve member for a control device having a passage provided with a valve seat for fuel flow therethrough, the needle valve member being adapted to cooperate with the valve seat for controlling the fuel flow therethrough while providing a minimum controlled fuel flow through the valve seat when the needle valve member is fully seated against the valve seat. The needle valve member comprises a drawn one-piece elongated substantially cup-shaped member having a thin tubular side wall and a thin end wall closing off one end of the tubular side wall, the end wall being adapted to close against the valve seat and having an opening therethrough to cause the minimum flow through the valve seat when the end wall is seated against the valve seat.