Patents by Inventor William J. Sipio

William J. Sipio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted acenaphthenes and their use as inhibitors of phospholipase A2
    Patent number: 4859697
    Abstract: Substituted acenaphthenes and their use as inhibitors of phospholipase A.sub.2 are provided. The acenaphthenes have the formula ##STR1## wherein R.sup.1 is H or alkyl;R.sup.2 is alkyl, cycloalkyl, or aryl; andR.sup.1 and R.sup.2 taken together are various aryl groups optionally substituted; andA is .dbd.O, .dbd.CH.sub.2 and derivatives thereof, ##STR2## and derivatives thereof, or .dbd.NOH and derivatives thereof.
    Type: Grant
    Filed: October 6, 1988
    Date of Patent: August 22, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: William C. Ripka, William J. Sipio
  • Substituted acenaphthenes and their use as inhibitors of phospholipase A.sub.2
    Patent number: 4806671
    Abstract: Substituted acenaphthenes and their use as inhibitors of phospholipase A.sub.2 are provided. The acenaphthenes have the formula ##STR1## wherein R.sup.1 is H or alkyl;R.sup.2 is alkyl, cycloalkyl, or aryl; andR.sup.1 and R.sup.2 taken together are various aryl groups optionally substituted; andA is .dbd.O, .dbd.CH.sub.2 and derivatives thereof, ##STR2## and derivatives thereof, or .dbd.NOH and derivatives thereof.
    Type: Grant
    Filed: May 7, 1986
    Date of Patent: February 21, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: William C. Ripka, William J. Sipio
  • Aryl oxo-alkynoates as 5-lipoxygenase inhibitors
    Patent number: 4624964
    Abstract: Aryl oxo-alkynoates are 5-lipoxygenase inhibitors, making them useful for the treatment of inflammation, chronic obstructive lung disease or psoriasis. These compounds have the formula: ##STR1## wherein n is 1-12;R.sup.1 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, or phenyl; andAryl is naphthyl, phenyl or phenyl substituted with a variety of groups.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: November 25, 1986
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: William J. Sipio