Abstract: Methods and systems are provided for forming clathrates to reduce or prevent corrosion in hydrocarbon facilities, such as pipelines, among others. An exemplary embodiment provides a method for isolating a corrosive gas in a hydrocarbon stream. The method includes combining a host compound with a hydrocarbon stream comprising a corrosive gas to form a clathrate, wherein a pressure or the reaction, a temperature of the reaction, or both, are controlled to maximize formation of a clathrate of the corrosive gas and minimize the formation of a clathrate of a hydrocarbon in the hydrocarbon stream. The clathrate is separated from the hydrocarbon stream and melted to remove the corrosive gas.