Patents by Inventor William J. Welch

William J. Welch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inducement of thermotolerance with benzoquinonoid ansamycins
    Patent number: 6015659
    Abstract: Thermotolerant phenotypes are developed in cells, tissues, organs and organisms by the administration of benzoquinonoid ansamycins such as herbimycin A and any of various analogs. The general stress tolerance resulting from this inducement offers benefits in a variety of ways, including rendering surgical patients more able to withstand the rigors of surgery, prolonging the shelf life of organs excised from organ donors, and prolonging the viability of tissue-cultured cells and organs.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: January 18, 2000
    Assignee: The Regents of the University of California
    Inventors: William J. Welch, Ramanujan Hegde
  • Correction of genetic defects using chemical chaperones
    Patent number: 5900360
    Abstract: The present invention provides methods of improving phenotypic defects that are caused by conformationally defective target proteins. The methods of the invention comprise exposing a cell that expresses a conformationally defective target protein with an amount of a protein stabilizing agent that is effective to improve the phenotypic defect. Nonlimiting examples of protein stabilizing agents include dimethylsulfoxide (DMSO), deuterated water, trimethylamine N-oxide (TMAO). Nonlimiting examples of defective target proteins to be treated include the cystic fibrosis transmembrane conductance regulator (CFTR) protein and prion proteins. In one embodiment, the invention provides methods for detecting protein stabilizing agents. In another embodiment, the invention provides methods for detecting cells and pathological conditions caused by improper folding and protein processing.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: May 4, 1999
    Inventors: William J. Welch, C. Randell Brown, Jorg Tatzelt
  • Method for preparation of 8-methoxy-4,8-dimethyl-1-(4-isopropylphenyl)-nonane
    Patent number: 4482751
    Abstract: Disclosed is a method for the preparation of 8-methoxy-4,8-dimethyl-1-(4-isopropylphenyl)-nonane which comprises the steps of(a) reacting para-isopropylbenzyl chloride with triphenylphosphine in the presence of a suitable solvent for a sufficient period of time and at a sufficient temperature to form an intermediate product in solution, para-isopropylbenzyl triphenylphosphonium chloride, and(b) reacting said solution with sodium methoxide, followed by methoxycitronellal to produce cis- and trans-8-methoxy-4,8-dimethyl-1-(4-isopropylphenyl)-1-nonene,(c) separating said intermediate product from the residual reactants, and(d) hydrogenating said cis- and trans-8-methoxy-4,8-1-(4-isopropylphenyl)-1-nonene, in the presence of a suitable solvent and catalyst to form 8-methoxy-4,8-dimethyl-1-(4-isopropylphenyl)-nonane.
    Type: Grant
    Filed: February 14, 1983
    Date of Patent: November 13, 1984
    Assignee: Stauffer Chemical Company
    Inventors: Kambiz Javdani, William J. Welch