Abstract: A delivery device can provide sequential delivery of a plurality of intraluminal devices or tacks held in a compressed state on the delivery device. Delivery platforms on the delivery device can hold a tack in a compressed position and have a unique shape, such as a non-constant outer diameter, an hourglass shape, a tapered proximal half, ridges, dimples, etc. This unique shape can be positioned between annular pusher bands that may also be radiopaque markers. In some embodiments, the unique shape is provided by a sleeve of flexible material with the unique shape surrounding a harder inner shaft. Further, the annular pusher bands can be made of wire or sections of material to increase flexibility while remaining radiopacity. A tack deployment method can include alignment of radiopaque markers on the outer sheath and the tack to be deployed prior to deployment.

Abstract: Disclosed herein are heart pumps that include a catheter assembly and that can be applied percutaneously. Some embodiments include a locking device that prevents components of the catheter assembly from being separated when in use. The catheter assembly can include an expandable tip. In some embodiments, the catheter assembly includes a housing having a wall structure, a portion of which can have a bulbuous shape or can be deformable. In other embodiments, the housing can be configured to reduce fluttering or deflection of the housing and/or to maintain a gap between the housing and an impeller blade disposed therein.

Abstract: Disclosed herein are heart pumps that include a catheter assembly and that can be applied percutaneously. Some embodiments include a locking device that prevents components of the catheter assembly from being separated when in use. The catheter assembly can include an expandable tip. In some embodiments, the catheter assembly includes a housing having a wall structure, a portion of which can have a bulbuous shape or can be deformable. In other embodiments, the housing can be configured to reduce fluttering or deflection of the housing and/or to maintain a gap between the housing and an impeller blade disposed therein.

Abstract: The invention generally relates to a system for closing an aperture in a patient, such as an aperture in a vessel wall of a patient. In certain embodiments, the invention provides a system for closing an aperture in a patient including a delivery device that is attachable to and removable from an exterior of an introducer sheath; and a clip releasably disposed within the delivery device.

Abstract: The invention generally relates to a system for closing an aperture in a patient, such as an aperture in a vessel wall of a patient. In certain embodiments, the invention provides a system for closing an aperture in a patient including a delivery device that is attachable to and removable from an exterior of the sheath, and a clip releasably disposed within the delivery device.

Abstract: The invention generally relates to systems and methods for closing an aperture in a patient, such as an aperture in a vessel wall of a patient. In certain embodiments, the invention provides a system for closing an aperture in a patient including a delivery device that is removably attachable to a medical device, and a clip releasably disposed within the delivery device. The clip includes tissue engaging members configured to engage bodily tissue of the patient. The clip includes a body portion biased towards a first configuration to facilitate closure of the aperture when the tissue engaging members are engaged with the bodily tissue.

Abstract: The invention generally relates to a system for closing an aperture in a patient, such as an aperture in a vessel wall of a patient. In certain embodiments, the invention provides a system for closing an aperture in a patient including an a delivery device that is attachable to and removable from an exterior of an introducer sheath and a clip releasably disposed within the delivery device.

Abstract: The invention generally relates to a system for closing an aperture in a patient, such as an aperture in a vessel wall of a patient. In certain embodiments, the invention provides a system for closing an aperture in a patient including a delivery device that is attachable to and removable from an exterior of an introducer sheath, and a clip releasably disposed within the delivery device.

Abstract: The present invention relates to a loaded reactive nanoscale latex particle synthesized from mixture of monomers containing water insoluble monomers, at least two ethylenically functionalities monomers, halo-aromatic-polyethyleneglycol-methacrylate, polyethyleneglycolacrylate containing macromonomers, and up to 10 wt % other ethylenic monomers different from above monomers. The reactive halo-aromatic groups on the surface of latex particle are servable as linkers to react with peptides, antibodies, nucleic acids, ligands or other biomolecules.

Abstract: The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent.

Abstract: The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent.

Abstract: An expandable intraluminal stent having a strut pattern made from a plurality of triangular cells is disclosed. Each triangular cell is formed from at least two V struts of different magnitudes aligned in phase and joined at opposite ends forming two opposed vertices of the triangle. A series of triangular cells are joined at the vertices to form a ring. The series of triangular cells may be arranged to form peaks in the ring, peaks and valleys in the ring, or a combination thereof. A plurality of the rings are aligned coaxially and joined by connecting elements to form a tubular shape. Use of the double V strut formation in the rings increases vessel wall coverage, reduces gap sizes, and does not impair the compressability of the stent for a small profile for delivery.

Abstract: A self-expanding stent for implantation into a body lumen, such as an artery, includes a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement to create at least one continuous spine which extends along the length of the stent. The cylindrical elements are nested when placed in a collapsed position. The cylindrical elements may include a W-shared portion to which the interconnecting members attach.

Abstract: The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent.

Abstract: A self-expanding stent for implantation into a body lumen, such as an artery, includes a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The stent has cylindrical elements at each end of the stent which includes a plurality of double curved portions.

Abstract: The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent.

Abstract: The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent.

Abstract: An expandable intraluminal stent having a strut pattern made from a plurality of triangular cells is disclosed. Each triangular cell is formed from at least two V struts of different magnitudes aligned in phase and joined at opposite ends forming two opposed vertices of the triangle. A series of triangular cells are joined at the vertices to form a ring. The series of triangular cells may be arranged to form peaks in the ring, peaks and valleys in the ring, or a combination thereof. A plurality of the rings are aligned coaxially and joined by connecting elements to form a tubular shape. Use of the double V strut formation in the rings increases vessel wall coverage, reduces gap sizes, and does not impair the compressability of the stent for a small profile for delivery.

Abstract: The invention is directed to a self-expanding stent for implantation into a body lumen, such as an artery. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common longitudinal stent axis and interconnected by a plurality of interconnecting members placed on the stent in a collinear arrangement such as to create at least one continuous spine which extends along the length of the stent. The invention is also directed to a stent delivery system for implantation of a stent in a vessel which includes an outer tubular member having a restraining sheath and an inner tubular member having a distal end which has a compressed stent mounted thereto. The proximal end of the inner tubular member is connected to a housing assembly which prevents the inner tubular member from moving when the outer tubular member is retracted to deploy the stent.

Abstract: A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): wherein X is oxygen or sulfur; R1-R4 each independently represent an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; L1, L2 and L3 each independently represent substituted or unsubstituted methine groups; M+ represents a proton or an inorganic or organic cation; and n is 0, 1, 2 or 3 and wherein the aggregated dye in the dispersion has an absorption halfbandwidth of less than 55 nm.