Abstract: The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and/or a geometry of a lumen orifice to control the flow of blood through the lumen.

Abstract: Described herein are methods and apparatuses for identifying a clot material in contact with a suction catheter. For example, an apparatus as described herein may include a flexible elongate body having a suction lumen, and an aspiration opening sensor comprising at least two electrodes, and a controller configured to distinguish between clot and blood based on an impedance signal between the two or more electrodes.

Abstract: Aspiration catheters for removing clot material from a patient, systems including these catheter as well as methods of making and using these aspiration catheters may be configured to remove clot material in long, continuous strips that prevent release of smaller clot fragments back into the vessel. Also described herein are blood collection apparatuses that may allow safe and easy reperfusion of collected blood.

Abstract: Described herein are methods and apparatuses for characterizing a material at a distal end of an aspiration catheter using one or more sensors. The methods and apparatuses described herein may include a plurality of sensing electrodes at a distal end region of the apparatus, and a controller configured to sense contact and/or close proximity to the sensing electrodes. These methods and apparatuses may determine or detect vessel size. These methods and apparatuses may include distal contrast ports for applying contrast material distal to the aspiration catheter. In some examples these apparatuses include one or more reference electrodes near the sensing electrodes that may enhance detection of material (e.g., clot, blood vessel wall). These methods and apparatuses may include a steerable distal end region. In some cases the apparatuses and methods may include a retriever probe to assist in capturing clot material.

Abstract: The invention disclosed here generally relates to devices used to identify the location of a never in order to modify a property of the nerve. Specifically, the invention utilized pre-operative scans of a patient's nasal cavity in order to identify target treatment locations when a nerve to be treated is located. The image of the nasal cavity and target treatment location can be registered with the real time position of the nasal cavity using a surgical navigation system in order to assist in guiding a surgical probe to the target treatment location.

Abstract: Apparatuses and methods for distinguishing a blood clot from a vessel wall. These methods and apparatuses may include an aspiration opening into a suction lumen, an aspiration opening sensor(s) positioned at a rim of the aspiration opening, and a controller that interprets signals from the aspiration opening sensor(s) to determine when the aspiration opening is contacting a clot material or a vessel when a force is applied.

Abstract: An illustrative system may include a stereoscopic imaging device comprising: a first image sensor having a first pixel array and configured to provide a first windowed output, the first windowed output comprising first image information associated with pixels included within a first window of the first pixel array, and a second image sensor having a second pixel array and configured to provide a second windowed output, the second windowed output comprising second image information associated with pixels included within a second window of the second pixel array, and an imaging control system configured to dynamically adjust at least one of the first position of the first window within the first pixel array or the second position of the second window within the second pixel array based on a working distance between a target surface within a scene and the stereoscopic imaging device.

Abstract: Systems and related methods for identifying and/or ablating targeted nerves are provided. A probe with stimulating electrodes and/or ablation members are provided. The probe may be inserted into a nasal cavity and current may be introduced through the electrodes to stimulate a targeted area. The response to stimulation may be used to identify the targeted nerve. Once identified, the ablation member may ablate the targeted nerve.

Abstract: Described here are methods and apparatuses for tracking a clot material within a lumen of a suction catheter. For example, an apparatus as described herein may include a flexible elongate body having a suction lumen, a first pair of electrodes within the suction lumen, a second pair of electrodes proximal to the first pair of electrodes, and a controller configured to track a clot material within the suction lumen based on signals from the first pair of electrodes and the second pair of electrodes.

Abstract: An electric water heater has upper and lower electric resistance type heating elements respectively controlled by a single pole, double throw upper thermostat and a single pole, single throw lower thermostat. The upper and lower thermostats are operatively interconnected by a wiring harness having outer conductor end portions that are connected to a terminal block portion of an external junction box to provide the water heater with a variety of heating element operating modes without having to replace either of the thermostats, vary the wiring harness interconnections therebetween, or vary the connection between the outer conductor end portions and the terminal block. The water heater may thus be advantageously manufactured in a single variant that may be easily and quickly modified in the field to selectively alter the heating element control mode of the water heater.

Abstract: A device for generating electricity in an irrigation system includes a water turbine, a generator, and a bypass valve. The water turbine converts the flow of water in the irrigation system into rotational energy. The generator is connected to the water turbine for converting the rotational energy into electrical energy. The bypass valve assembly is in fluid communication with the water turbine and the irrigation system and is configured to regulate the flow of water through the water turbine and to direct excess water around the water turbine and back into the irrigation system. The device is configured to generate electricity while maintaining a predetermined flow rate in the irrigation system and to direct excess water around the water turbine and back into the irrigation system when the flow of water through the water turbine exceeds the predetermined flow rate.

Abstract: The present technology relates to interatrial shunting systems and methods. In some embodiments, the present technology includes a method for monitoring a shunting element implanted in a patient and having a lumen fluidly coupling cavities of the patient's heart. The method can comprise obtaining first and second radiographic images of at least two radiopaque elements associated with the lumen of the shunting element. A spatial relationship between the radiopaque elements varies according to a size of the lumen. The first radiographic image can be taken from a first viewing angle and the second radiographic image can be taken from a second viewing angle generally orthonormal to the first viewing angle. The method also includes determining the size of the lumen based, at least in part. on locations of the radiopaque elements in the first and second radiographic images.

Abstract: A system is provided which includes a plurality of users, each having a mobile Web3 node associated therewith, wherein each mobile Web3 node is equipped with a tangible, non-transient memory device having a set of software instructions recorded. The software instructions, when executed by at least one compute processor, perform the steps of establishing a hardware root of trust, establishing a biometric binding which is unique among the mobile Web3 nodes, and creating an AI with a user interface. The user interface receives input from a user and uses the input to generate privacy preserved zero-ID transactions, and to create a private chain network on the mobile Web3 node to establish and secure a P2P control channel for all communication with at least some of the plurality of users.

Abstract: An apparatus including a pixel array comprising two or more photo-sensor elements; a first optical filter disposed on a first photo-sensor element of the pixel array, the first optical filter configured such that a spectral response of the first optical filter includes: a first passband in a first wavelength range, and a second passband in a second wavelength range, the first passband and the second passband being separated by a first stop band; and a second optical filter disposed on a second photo-sensor element of the pixel array, the second optical filter configured such that a spectral response of the second optical filter includes: a third passband in the first wavelength range, and a fourth passband in the second wavelength range, the third passband and the fourth passband being separated by a second stop band; wherein the second passband and the fourth passband are discrete passbands in an infrared range.

Abstract: An illustrative system may include a stereoscopic imaging device comprising: a first image sensor having a first pixel array and configured to provide a first windowed output comprising first image information associated with pixels included within a first window of the first pixel array, the first window having a first position; and a second image sensor having a second pixel array and configured to provide a second windowed output comprising second image information associated with pixels included within a second window of the second pixel array, the second window having a second position; and an imaging control system that may be configured to: determine a working distance between a target surface within a scene and the stereoscopic imaging device; and adjust one or more of the first position of the first window within the first pixel array or the second position of the second window within the second pixel array.

Abstract: The invention disclosed here generally relates to devices that can modify a property of a nerve. Specifically, the subject invention is contemplated to modify the posterior nasal nerve signal conduction in such a way so as to reduce the signals transmitted to the nasal cavity. Reduction or interruption of the nerve signals results in the reduction of the distal organ activity. In particular, embodiments of the present invention allow for increased lateral contact or apposition of the target tissue region having at least one posterior nasal nerve with the end effector surface by lateral and/or longitudinal translation of the end effector relative to the surgical probe shaft. This improved lateral surface contact has several benefits, including improved patient outcomes and patient safety as the end effector is adequately in contact with target tissue for subsequent ablation therapy.

Abstract: The present technology is directed to adjustable interatrial shunting systems that selectively control blood flow between the left atrium and the right atrium of a patient. The adjustable interatrial devices include a shunting element having an outer surface configured to engage native tissue and an inner surface defining a lumen that enables blood to flow from the left atrium to the right atrium when the system is deployed across the septal wall. The systems can include an actuation assembly for selectively adjusting a geometry of the lumen and/or a geometry of a lumen orifice to control the flow of blood through the lumen.

Abstract: Disclosed herein are monoclonal antibodies that specifically bind to human mature Factor D and that do not bind to human Pro-Factor D, monoclonal antibodies that specifically bind to human Pro-Factor D and do not bind to human mature Factor D, and monoclonal antibodies that bind to both human mature Factor D and human Pro-Factor D. Also disclosed are methods of using the monoclonal antibodies, and compositions comprising the same, for detection of the mature and/or the pro-form of Factor D in biological samples, to determine the status of the Alternative Pathway of Complement (APC) in a mammalian subject, or to determine the status of Factor D after treatment with a MASP-3 inhibitory agent which inhibits the conversion of Pro-Factor D to mature Factor D.

Abstract: An image sensing apparatus including a pixel array comprising two or more photo-sensor elements, a first optical filter disposed on a first photo-sensor element of the pixel array and a second optical filter disposed on a second photo-sensor element of the pixel array. The first optical filter is configured such that a spectral response of the first optical filter includes a first passband in a first wavelength range and a second passband in a second wavelength range, where the first passband and the second passband are separated by a first stop band. The second optical filter is configured such that a spectral response of the second optical filter includes a third passband in the first wavelength range and a fourth passband in the second wavelength range, where the third passband and the fourth passband are separated by a second stop band.

Abstract: Described here are methods and apparatuses for tracking a clot material within a lumen of a suction catheter. For example, an apparatus as described herein may include a flexible elongate body having a suction lumen, a first pair of electrodes within the suction lumen, a second pair of electrodes proximal to the first pair of electrodes, and a controller configured to track a clot material within the suction lumen based on signals from the first pair of electrodes and the second pair of electrodes.