Patents by Inventor William John Nodes

William John Nodes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polyheteroarl histone deacetylase inhibitors and their use in therapy
    Patent number: 10533003
    Abstract: The present invention is a compound having the following formula: or a pharmaceutically acceptable salt thereof, wherein e.g. L and Y are each independently an optionally substituted 6-membered nitrogen-containing heteroaryl; M is an optionally substituted 5- to 10-membered heteroaryl; W is a zinc-binding group; each R2 is independently hydrogen or C1-C6 alkyl; and R3 is an aryl or heteroaryl. The compounds are useful as histone deacetylase (HDAC) inhibitors.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: January 14, 2020
    Assignee: Karus Therapeutics Limited
    Inventors: Stephen Joseph Shuttleworth, Alexander Richard Liam Cecil, Somhairle MacCormick, William John Nodes, Cyrille Davy Tomassi, Franck Alexandre Silva
  • Diheteroaryl histone deacetylase inhibitors and their use in therapy
    Patent number: 10407435
    Abstract: The present invention is a compound having the following formula: (Formula (I)) or a pharmaceutically acceptable salt thereof, wherein e.g. X is C or N; n is 1 to 10; each L is independently a 5- to 12-membered heteroaryl containing at least two nitrogen atoms; and W is a zinc-binding group. The compounds are useful as histone deacetylase (HDAC) inhibitors.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: September 10, 2019
    Assignee: Karus Therapeutics Limited
    Inventors: Stephen Joseph Shuttleworth, Alexander Richard Liam Cecil, Somhairle MacCormick, William John Nodes, Cyrille Davy Tomassi
  • DIHETEROARYL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY
    Publication number: 20170313712
    Abstract: The present invention is a compound having the following formula: (Formula (I)) or a pharmaceutically acceptable salt thereof, wherein e.g. X is C or N; n is 1 to 10; each L is independently a 5- to 12-membered heteroaryl containing at least two nitrogen atoms; and W is a zinc-binding group. The compounds are useful as histone deacetylase (HDAC) inhibitors.
    Type: Application
    Filed: October 29, 2015
    Publication date: November 2, 2017
    Inventors: Stephen Joseph Shuttleworth, Alexander Richard Liam Cecil, Somhairle MacCormick, William John Nodes, Cyrille Davy Tomassi
  • POLYHETEROARL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY
    Publication number: 20170313698
    Abstract: The present invention is a compound having the following formula: or a pharmaceutically acceptable salt thereof, wherein e.g. L and Y are each independently an optionally substituted 6-membered nitrogen-containing heteroaryl; M is an optionallysubstituted 5- to 10-membered heteroaryl; W is a zinc-binding group; each R2 is independently hydrogen or C1-C6 alkyl; and R3 is an aryl or heteroaryl. The compounds are useful as histone deacetylase (HDAC) inhibitors.
    Type: Application
    Filed: October 29, 2015
    Publication date: November 2, 2017
    Inventors: Stephen Joseph Shuttleworth, Alexander Richard Liam Cecil, Somhairle MacCormick, William John Nodes, Cyrille Davy Tomassi, Franck Alexandre Silva