Patents by Inventor William John Smith, III

William John Smith, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for R (+) 1,2,3,6-tetrahydro-4-phenyl-1-?(3-phenyl-3-cyclohexen-1-yl)methyl!pyridi ne, a central nervous system agent
    Patent number: 5710277
    Abstract: An improved process for the preparation of R(+)1,2,3,6-tetrahydro-4-phenyl-1-?(3-phenyl-3-cyclohexen-1-yl)methyl!pyri dine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboylic acid or .alpha.-chymotrypsin to selectively hydrolyze n-butyl 5-oxo-3-phenyl-3-cycohexenecarboxylate to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: January 20, 1998
    Assignee: Warner-Lambert Company
    Inventors: Donald Eugene Butler, Jodette Gailey, Tung Van Le, William John Smith, III, David Juergen Wustrow