Abstract: The present disclosure provides compositions and methods for extended release of certain types of antibodies in vivo. It was discovered that such antibodies are able to initiate reversible gelation of hyaluronic acid (HA) by creating a depot that dissociates over time to release the antibody without any impact on its physical and chemical properties as well as its biological activity. As certain tissues and organs, such as eyes, joints and skins, contain HA, local injection of the antibodies to these tissues or organs will result in embedding of the antibody in gel formed from the HA, which becomes a repository of slow-released antibodies. In addition, slow-released formulations can be prepared with antibodies mixed with HA, optionally with other polymers.

Abstract: A system includes a switch configured to couple a generator to a utility grid, a first converter having a first port coupled to the generator, a second converter having a first port coupled to a second port of the first converter and a second port coupled to the utility grid, and a controller configured to control the switch and the first and second converters. The controller may be configured to cause the first and second converters to provide power to the utility grid from the generator after the generator starts and before a state of the generator meets a predetermined criterion.

Abstract: The present disclosure describes systems and methods for determining if a feature of interest is present in a volume or plane scanned by an imaging system. In examples, one or more imaging planes are analyzed for anatomical landmarks to determine whether a feature of interest is present. If the feature of interest is present, scan parameters may be determined to scan an adjusted volume that includes the feature of interest. In some applications, the adjusted volume may allow the imaging system to increase a volume rate.

Abstract: A silicone-polyacrylate copolymer has the formula Xg[ZjYo]c, where each X is an independently selected silicone moiety having a particular structure, each Y is an independently selected polyacrylate moiety, each Z is an independently selected siloxane moiety, subscript c is from 1 to 150, subscript g is >1, 0?j<2, and 0<o<2, with the proviso that j+o=2 in each moiety indicated by subscript c. Methods of preparing the silicone-polyacrylate copolymer are also disclosed. Further, a sealant is disclosed, the sealant comprising the silicone-polyacrylate copolymer and a condensation-reaction catalyst.

Abstract: Apparatus and methods for monitoring the status of a floating roof. The floating-roof tank assembly has: an impermeable roof section, and a floating-roof seal configured to span between the impermeable roof section and components of a container. One or more deformable floats are attached to the roof section to provide buoyancy so that the roof floats on top of the liquid contained in the container. To monitor the status of the floating roof tank, it is provided with a fiber optic sensor array comprising one or more fiber optic sensors. A light source configured to transmit light to the fiber optic sensors and a receiver configured to detect light from each fiber optic cable after it has interacted with the fiber optic cable. Based on the received light, a controller configured to process the light received by the receiver to determine the status of the floating roof tank.

Abstract: A trimming device for trimming a carcass part having a skin and/or fat side, including a blade having a cutting edge facing a front face of the carcass part, and a blade holder for holding the blade. The blade holder has a tiltable blade holder segment and a non-tiltable blade holder segment rotatably coupled to the non-tiltable blade holder segment around an axis of rotation parallel to a conveying direction along which the carcass part is transported to the trimming device, and an actuator configured to tilt the tiltable blade holder segment relative to the non-tiltable blade holder segment based on information concerning a profile of the skin and/or fat side. A geometry of the cutting edge changes when the tiltable blade holder segment is tilted relative to the non-tiltable blade holder segment by means of the actuator to trim the skin and/or fat side into a predetermined shape.

Abstract: There is set forth herein, in one embodiment, receiving, by a transceiver of a UE device an aggregate signal stream, the aggregate signal stream including an aggregate of base station downlink signal streams from a plurality of base stations; and processing the aggregate signal stream.

Abstract: An automated storage and retrieval system includes a first independently operable section having a first number of predetermined storage and retrieval transactions, and a second independently operable section in communication with the first independently operable section and having a second number of predetermined storage and retrieval transactions. The first and second independently operable sections are configured to provide a respective number of predetermined storage and retrieval transactions so that the first number of predetermined storage and retrieval transactions substantially matches the second number of predetermined storage and retrieval transactions.

Abstract: In accordance with one or more aspects of the disclosed embodiment, a lift includes at least one load handling device configured so as to reciprocate along a lift axis, the load handling device including a frame forming a payload section with a payload support surface having a common elevation configured to hold one or more pickfaces at the common elevation of the payload support surface, at least one transfer arm movably mounted to the frame, and a drive section connected to the load handling device and being configured to move the load handling device along the lift axis, wherein the one or more pickfaces carried in unison by the payload support surface of the at least one load handling device, define an order sequence of pickfaces on the at least one load handling device according to a predetermined case out order sequence of mixed cases.

Abstract: The present invention relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R1—R16, n and p are defined herein. The novel nitrogen-linked benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth, such as cancer, in patients.

Abstract: A start-up routine for a mass spectrometer is performed automatically upon switching ON the mass spectrometer. The mass spectrometer comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use. The start-up routine comprises detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection.

Abstract: Technology is disclosed herein for content assistance processes via foundation model integrations in software applications. In an implementation, a computing device receives natural language input from a user relating to content of a document in a user interface of an application. The computing device generates a first prompt for a foundation model to generate at least a completion to the natural language input. The computing device receives a reply to the first prompt from the foundation model which includes a completion to the natural language input. The computing device causes display of the completion in association with the natural language input in the user interface and receives user input comprising an indication to combine the input and the completion, resulting in a revised natural language input. The computing device submits a second prompt including the revised natural language input to the foundation model.

Abstract: Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

Abstract: Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

Abstract: Provided is a method for providing a substrate with an ablative coating using a one-part room temperature curable and sprayable ablative silicone composition. The one-part room temperature curable and sprayable ablative silicone composition is generally thixotropic and cures in depth within 24 hours to provide an ablative or thermal protective layer on an article. The one-part room temperature curable and sprayable ablative silicone composition is substantially free from diluents or solvents. An article having such a coating and the use of the one-part room temperature curable and sprayable ablative silicone composition in the preparation of such an article are also provided.

Abstract: A silicone-polyester copolymer has the formula Xg[ZjYo]c, where each X is an independently selected silicone moiety having a particular structure, each Y is an independently selected polyester moiety, each Z is an independently selected siloxane moiety, subscript c is from 1 to 150, subscript g is >1, 0?j<2, and 0<o<2, with the proviso that j+o=2 in each moiety indicated by subscript c. Methods of preparing the silicone-polyester copolymer are also disclosed. Further, a sealant is disclosed, the sealant comprising the silicone-polyester copolymer and a condensation-reaction catalyst.

Abstract: A start-up routine for a mass spectrometer is performed automatically upon switching ON the mass spectrometer. The mass spectrometer comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use. The start-up routine comprises detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection.