Abstract: The present invention relates to heterocyclic compounds, pharmaceutical compositions thereof, and methods which may be useful as inhibitors of IGF-1R for the treatment or prevention of thyroid eye disease (TED), also known as thyroid-associated ophthalmopathy (TAO), or Graves' ophthalmopathy or orbitopathy (GO).

Abstract: A carriage unit for binder jetting additive manufacturing of components. A carriage body is movably mounted to a carriage frame within a printer unit and configured to traverse relative to a work surface. Two compaction rollers are mounted to the carriage body. Each is configured to move between a retracted position disengaged from build material powder to a deployed condition to recoat build material powder over a work surface. A powder dispensing unit is mounted to the carriage body and configured to dispense a metered amount of the build material powder as the carriage body traverses over the work surface. A print head mounted to the carriage body is configured to deposit a predetermined pattern of binder as the carriage unit traverses relative to the work surface.

Abstract: The disclosure relates to betaretroviruses (genus Betaretrovirus), and recombinant betaretroviral envelope (rENV) protein for use in viral vector platforms, an engineered delivery vehicle and gene therapy, their associated methods of use and manufacture. In particular, the present disclosure provides compositions and methods to tune betavirus envelope proteins such that they target a particular cell surface receptor; i.e., are cell and/or tissue-type specific, allowing for better site-specific transgene delivery and expression.

Abstract: An aircraft cockpit training simulator includes a plurality of aircraft cockpit simulation panels and power over Ethernet (POE) cabling extending therebetween. Each panel includes a simulator user interface device, an input circuit or an output circuit, a POE interface circuit, and a distributed controller coupled to the input circuit or output circuit and POE interface device and asynchronously communicating with other controllers using a publish/subscribe protocol. A host controller is coupled to the distributed controllers via the POE cabling and operates the aircraft cockpit simulation panels using a host computer model. The distributed controllers may operate independent of the host computer model.

Abstract: Systems and methods for Endovascular Perfusion Augmentation for Critical Care (EPACC) are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient. The system may also include a catheter controller unit that causes the expandable aortic blood flow regulation device to expand and contract to restrict blood flow through the aorta.

Abstract: A polymeric film has an orthogonal length, width and thickness. The polymeric film includes first and second substrates spaced apart along the thickness and a plurality of crumpled elements extending between the first and second substrates and along the length. The crumpled elements are substantially coextensive with the first and second substrates along the length and are spaced apart along the width.

Abstract: Exemplary embodiments disclosed herein are directed to systems and methods by which the contents of a container, such as the level of liquid nitrogen in one or more liquid nitrogen storage containers, can be locally and/or remotely monitored, and alerts can be generated if a leak is detected. The weight of the container, or a combination of the weight and the temperature of the container, may be monitored with respect to detecting a leak.

Abstract: A dustcap comprises a body having a cylindrical portion configured to receive a ferrule of an optical fiber connector, and an end portion opposite the cylindrical portion. The end portion includes a receptacle. The dustcap has a built-in cleaner disposed within the receptacle. The dustcap further comprises a removable cover configured to couple to the end portion of the dustcap. In another embodiment, the end portion includes a flat surface, the cleaner is disposed on the flat surface of the end portion, and the cover is configured to receive the end portion of the dustcap. In another embodiment, the cover has a receptacle and the cleaner is disposed within the receptacle, whereas the body comprises an end portion configured to receive at least a portion of the cover with the built-in cleaner. Embodiments encompass cleaner assemblies and adapter dustcaps having built-in cleaners.

Abstract: An automated storage and retrieval system includes a first independently operable section having a first number of predetermined storage and retrieval transactions, and a second independently operable section in communication with the first independently operable section and having a second number of predetermined storage and retrieval transactions. The first and second independently operable sections are configured to provide a respective number of predetermined storage and retrieval transactions so that the first number of predetermined storage and retrieval transactions substantially matches the second number of predetermined storage and retrieval transactions.

Abstract: There is set forth herein, in one embodiment, receiving, by a transceiver of a UE device an aggregate signal stream, the aggregate signal stream including an aggregate of base station downlink signal streams from a plurality of base stations; and processing the aggregate signal stream.

Abstract: In accordance with one or more aspects of the disclosed embodiment, a lift includes at least one load handling device configured so as to reciprocate along a lift axis, the load handling device including a frame forming a payload section with a payload support surface having a common elevation configured to hold one or more pickfaces at the common elevation of the payload support surface, at least one transfer arm movably mounted to the frame, and a drive section connected to the load handling device and being configured to move the load handling device along the lift axis, wherein the one or more pickfaces carried in unison by the payload support surface of the at least one load handling device, define an order sequence of pickfaces on the at least one load handling device according to a predetermined case out order sequence of mixed cases.

Abstract: Provided are polycistronic vectors for co-expression of one or more tolerogenic factors, one or more CARs, and optionally one or more safety switches, as well as compositions comprising the same, cells comprising the same and methods of generating those cells, and methods of using the disclosed vectors, compositions, and cells to treat diseases such as cancer, diabetes, and neurological diseases.

Abstract: A start-up routine for a mass spectrometer is performed automatically upon switching ON the mass spectrometer. The mass spectrometer comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use. The start-up routine comprises detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection.

Abstract: Technology is disclosed herein for content assistance processes via foundation model integrations in software applications. In an implementation, a computing device receives natural language input from a user relating to content of a document in a user interface of an application. The computing device generates a first prompt for a foundation model to generate at least a completion to the natural language input. The computing device receives a reply to the first prompt from the foundation model which includes a completion to the natural language input. The computing device causes display of the completion in association with the natural language input in the user interface and receives user input comprising an indication to combine the input and the completion, resulting in a revised natural language input. The computing device submits a second prompt including the revised natural language input to the foundation model.

Abstract: A turbine engine comprising an engine core having a rotor and a stator, and a floating seal assembly sealing at least portions of the rotor and the stator relative to a higher-pressure area and a lower-pressure area. The floating seal assembly can comprise a carriage assembly at least partially defining a seal cavity and a seal body floating within the seal cavity. The floating seal assembly can further include at least one of a seal located between the seal body and the carriage assembly, and a seal face located between the seal body and the carriage assembly.

Abstract: Apparatuses, systems, and methods are disclosed for providing controlled delivery of energy treatment to a tissue site. The systems, apparatuses, and methods may include designs with features for efficiently deploying and adjusting electrodes at a tissue site for treatment and for facilitating retraction of the electrodes back into a housing after completion of treatment for removal. The systems, apparatuses, and methods may further include an expansion member for radially expanding the flexible substrate to aid in positioning the electrodes adjacent the tissue to facilitate treatment.

Abstract: Articles are described comprising a first substrate and a second substrate. At least one adhesive layer is disposed between the first and second substrates. The article further comprises a multilayer film within at least a portion of the adhesive layer(s). Also described is a method of disassembly comprising providing an adhesively bonded article as described herein; and separating the first substrate from the second substrate by delaminating the (e.g. multilayer) film. In other embodiments, adhesive articles (e.g. tape) are described comprising a (e.g. multilayer) film and methods of making adhesively bonded articles that comprise a (e.g. multilayer) film. Also described are methods of reworking, repairing, repurposing, or recycling an article, and articles.

Abstract: Apparatuses, systems, and methods are disclosed for providing controlled delivery of energy treatment to a tissue site. The systems, apparatuses, and methods may include medical instrument designs with features for retaining a flexible substrate with an electrode array in position against an expandable member during delivery to the tissue site, treatment, and retraction from the tissue site. The medical instrument further includes features for retaining the flexible substrate in a compact, stowed configuration during delivery and for retracting the flexible substrate post-deployment to facilitate retraction of the medical instrument after completion of treatment.

Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).