Abstract: Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.

Abstract: An example virtualized computing system includes: a host cluster having hosts and a virtualization layer executing on hardware platforms of the hosts, the virtualization layer supporting execution of virtual machines (VMs); an orchestration control plane integrated with the virtualization layer, the orchestration control plane including a master server executing in a first VM of the VMs; guest cluster infrastructure software (GCIS) executing in the master server, the GCIS configured to create a set of objects defining a container orchestration cluster, and manage lifecycles of second VMs of the VMs based on state of the set of objects; and guest software executing in the second VMs to implement the container orchestration cluster as a guest cluster of the host cluster, the guest software having components that interface with the GCIS.

Abstract: An automated storage and retrieval system includes a first independently operable section having a first number of predetermined storage and retrieval transactions, and a second independently operable section in communication with the first independently operable section and having a second number of predetermined storage and retrieval transactions. The first and second independently operable sections are configured to provide a respective number of predetermined storage and retrieval transactions so that the first number of predetermined storage and retrieval transactions substantially matches the second number of predetermined storage and retrieval transactions.

Abstract: A system for visualization and quantification of ultrasound imaging data according to embodiments of the present disclosure may include a display unit, and a processor communicatively coupled to the display unit and to an ultrasound imaging apparatus for generating an image from ultrasound data representative of a bodily structure and fluid flowing within the bodily structure. The processor may be configured to estimate axial and lateral velocity components of the fluid flowing within the bodily structure, determine a plurality of flow directions within the image based on the axial and lateral velocity components, differentially encode the flow directions based on flow direction angle to generate a flow direction map, and cause the display unit to concurrently display the image including the bodily structure overlaid with the flow direction map.

Abstract: The present disclosure describes ultrasound systems configured to enhance flow imaging and analysis by adaptively adjusting one or more imaging parameters in response to acquired flow measurements. Example systems can include an ultrasound transducer and one or more processors. Using the system components, mean flow velocity magnitude and acceleration can be determined within a target region during an acquisition phase, which may include a cardiac cycle. One or more adjusted flow imaging parameters, such as adjusted ensemble length, temporal smoothing filter length and/or step size, can be determined based on the acquired flow measurements to increase the signal quality of newly acquired ultrasound echo signals. The adjusted flow imaging parameters can then be applied by the ultrasound transducer during a second acquisition phase.

Abstract: In one aspect, the present disclosure includes a curtain wall panel having an inner core material sandwiched between two outer walls and at least one elastic member inserted into at least one channel formed by the inner core material. In some aspects, the present disclosure provides a curtain wall system including a plurality of adjacent panels of the present disclosure and at least one joining member configured to be received within a recess formed by the at least one elastic member of at least two of the plurality of adjacent panels. In another aspect, the present disclosure provides a method for assembling a curtain wall system of the present disclosure.

Abstract: A heart valve sizer and sizer cover are provided for determining the size of a heart valve annulus. The valve sizer can include a handle, a shaft extending distally from the handle, a sizing element coupled to the distal end of the shaft, the sizing element being movable between a first retracted position and a second expanded position, and a sizer cover. The sizer cover can be formed from a continuous sheet of material configured to surround at least a portion of the sizing element of the heart valve sizer so as to guard against entanglement of the sizing element with structures of a human heart.

Abstract: An apparatus includes a first member having a housing that encloses a power source and a controller, a second member coupled to the first member that is seeded with a target product, and a sensing module coupled to the first member to allow power from the power source to be transmitted to the sensing module and sensor data from the sensing module to be transmitted to the controller. The sensing module including a sensor oriented toward at least a portion of the second member. The sensor configured to obtain sensor data associated with at least one characteristic of the target product.

Abstract: A sensor pod system includes one or more sensor pods with a plurality of sensors configured to collect data from an environment. A sensor pod may have an effective field of view created by individual sensors with overlapping fields of view. The sensor pod system may include sensors of different types and modalities. Sensor pods of the sensor pod system may be modularly installed on a vehicle, for example, an autonomous vehicle and collect and provide data of the environment during operation of the vehicle.

Abstract: Accessories of a medical device, such as a defibrillator, are described. The accessories reduce delays in treating or monitoring a patient by increasing the efficiency of using, and the ease of use of, the medical device. An adjustable kickstand is movable between a collapsed and extended position to recline the medical device. In the reclined position, a display of the medical device can be more easily viewed by the user. Storage bags can be coupled to the medical device to efficiently store accessories for use with the medical device. The stored accessories can be coupled to the medical device while the accessories are stored within the storage bags. A port guard can protect and shield a connection between a cable and a port of the medical device to prevent the cable (e.g., an ECG cable) from being disconnected from the port of the medical device.

Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: A gimbal joint includes a monolithic first member including a first connection portion; and a monolithic second member including a second connection portion engaged with the first connection portion such that the monolithic first member and the monolithic second member are configured to move relative to each other about a plurality of axes. The first member may include a plurality of structural portions and a support base. The support base may include an axially-extending aperture that extends through the support base.

Abstract: Systems and methods are provided for creating and executing a decision network that includes a number of stations configured to operate with respect to an instance of a document, container or other object. A user interface may be presented to a user that includes selectable options for configuring and connecting stations within the decision network, and for establishing executable logic for each station to modify or create data within fields of a container instance. Different stations in the decision network may be assigned different permissions with respect to the container. Individual stations in the decision network may be configured to determine a prediction or probability based on data accessible to the given station, where the prediction or probability of one station may be based in part on an earlier prediction or probability determined at another station of the decision network.

Abstract: In one aspect, a method carried out by a content-presentation device may include transmitting a consent-processing request, including an identifier string unique to the device, to a consent management platform disposed in a computing cloud. The string may be used to establish an interactive session for user selection of consent options associated with a consent package having consent features of a media distribution system that require user consent for activation on the device. The consent package may be one of multiple consent packages targeted for the device by the consent management platform. The interactive session may prompt for consent choices of consent options, each choice being acceptance or rejection of consent to activating features of the consent package. The consent choices may be provided to the consent management platform via the interactive session, and corresponding information may be stored in a device-based activation whitelist for each consent-to feature.

Abstract: There is set forth herein, in one embodiment, receiving, by a transceiver of a UE device an aggregate signal stream, the aggregate signal stream including an aggregate of base station downlink signal streams from a plurality of base stations; and processing the aggregate signal stream.

Abstract: An instrument for facilitating transseptal delivery of a cardiac therapeutic device is positionable in a left ventricle. The instrument includes an elongate shaft having a tubular lumen, the shaft having a proximal portion and a distal portion actively steerable between a generally straight position and a curved position. An external pull wire and an internal pull wire are each actuatable to move the distal portion to the curved position. The external pull wire extends internally through the proximal portion of the shaft and longitudinally along the exterior of the distal portion of the shaft, while the internal pull wire extends internally through the proximal portion of the shaft adjacent to the external pull wire, and extends internally through the distal portion of the shaft.

Abstract: In one or more embodiments, a power distribution unit may include: multiple power distribution module (PDM) receptacles, in which each PDM receptacle is configured to receive a PDM along a longitudinal axis of the PDM receptacle and is configured with multiple conductors disposed along a plane orthogonal to the longitudinal axis; first multiple power outlets coupled to a first PDM receptacle of the multiple PDM receptacles, in which the first multiple power outlets are configured to provide first single-phase power to first multiple information handling systems housed by a rack; and second multiple power outlets coupled to a second PDM receptacle of the multiple PDM receptacles, in which the second multiple power outlets are configured to provide second single-phase power to second multiple information handling systems housed by the rack. In one or more embodiments, a monitoring device of the power distribution unit may monitor one or more environmental attributes.

Abstract: In accordance with one or more aspects of the disclosed embodiment, a lift includes at least one load handling device configured so as to reciprocate along a lift axis, the load handling device including a frame forming a payload section with a payload support surface having a common elevation configured to hold one or more pickfaces at the common elevation of the payload support surface, at least one transfer arm movably mounted to the frame, and a drive section connected to the load handling device and being configured to move the load handling device along the lift axis, wherein the one or more pickfaces carried in unison by the payload support surface of the at least one load handling device, define an order sequence of pickfaces on the at least one load handling device according to a predetermined case out order sequence of mixed cases.

Abstract: An apparatus includes a first member having a housing that encloses a power source and a controller, a second member coupled to the first member that is seeded with a target product, and a sensing module coupled to the first member to allow power from the power source to be transmitted to the sensing module and sensor data from the sensing module to be transmitted to the controller. The sensing module including a sensor oriented toward at least a portion of the second member. The sensor configured to obtain sensor data associated with at least one characteristic of the target product.

Abstract: The present disclosure provides compositions and methods for intra-articular delivery of anti-CSF1R antibodies to a tissue that is impacted by a disease that is treatable with CSF1/CSF1R inhibition and/or that expresses CSF1R. It was conventional knowledge that the intra-articular dwell time of proteins in joints is typically a few hours or less. The present disclosure shows, however, that intra-articular delivery of an anti-CSF1R antibody can lead to sustained exposure and pharmacologic activity of the antibody in the joints far beyond a few hours, providing an effective means for targeted and extended delivery of the therapeutic agent.