Patents by Inventor William K. Kappel

William K. Kappel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal chelating compositions for protein purification, detection or binding
    Patent number: 7709612
    Abstract: A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)— or —C(?O)—; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl or alkenyl; X is —(CH2)kCH3, —(CH2)kCOOH, —(CH2)kSO3H, —(CH2)kPO3H2, —(CH2)kN(J)2, or —(CH2)kP(J)2, preferably —(CH2)kCOOH or —(CH2)kSO3H; k is an integer from 0 to 2; J is hydrocarbyl or substituted hydrocarbyl; Y is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; Z is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; and i is an integer from 0 to 4, preferably 1 or 2.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: May 4, 2010
    Assignee: Sigma-Aldrich Co.
    Inventors: William K. Kappel, Vankatappa Viswanatha, Handong Li, Richard J. Mehigh, John G. Dapron
  • Metal chelating compositions for protein purification, detection or binding
    Patent number: 7033520
    Abstract: A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is -A-T-CH(X)— or —C(?O)—; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl or alkenyl; X is —(CH2)kCH3, —(CH2)kCOOH, —(CH2)kSO3H, —(CH2)kPO3H2, —(CH2)kN(J)2, or —(CH2)kP(J)2, preferably —(CH2)kCOOH or —(CH2)kSO3H; k is an integer from 0 to 2; J is hydrocarbyl or substituted hydrocarbyl; Y is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; Z is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; and i is an integer from 0 to 4, preferably 1 or 2.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: April 25, 2006
    Assignee: Sigma-Aldrich Co.
    Inventors: William K. Kappel, Venkatappa Viswanatha, Handong Li, Richard J. Mehigh, John G. Dapron
  • Solid phase cell lysis and capture platform
    Publication number: 20040259162
    Abstract: The present invention provides containers, processes, and kits relating to the extraction or the extraction and isolation of a cellular component from a host cell. More specifically, the containers of the invention comprise a mouth; an interior surface comprising a sidewall formation and a bottom; a volume; a lytic reagent; and in some instances, a supported capture ligand. Methods and kits for the extraction or the extraction and isolation of a cellular component from a host cell using the containers described herein are also provided.
    Type: Application
    Filed: May 3, 2004
    Publication date: December 23, 2004
    Applicant: Sigma-Aldrich Co.
    Inventors: William K. Kappel, Richard J. Mehigh, Elizabeth A. Jenkins
  • Metal chelating compositions for protein purification, detection or binding
    Publication number: 20040092031
    Abstract: A metal chelating composition having the formula: 1
    Type: Application
    Filed: September 22, 2003
    Publication date: May 13, 2004
    Applicant: Sigma - Aldrich Co.
    Inventors: William K. Kappel, Venkatappa Viswanatha, Handong Li, Richard J. Mehigh, John G. Dapron
  • Metal chelating compositions
    Patent number: 6623655
    Abstract: A metal chelating composition having the formula: wherein Q is a carrier; S1 is a spacer; L is —A—T—CH(X)— or —C(═O)—; A is an ether, thioether, selenoether, or amide linkage; T is a bond or substituted or unsubstituted alkyl or alkenyl; X is —(CH2)kCH3, —(CH2)kCOOH, —(CH2)kSO3H, —(CH2)kPO3H2, —(CH2)kN(J)2, or —(CH2)kP (J)2, preferably —(CH2)kCOOH or —(CH2)kSO3H; k is an integer from 0 to 2; J is hydrocarbyl or substituted hydrocarbyl; Y is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; Z is —COOH, —H, —SO3H, —PO3H2, —N(J)2, or —P(J)2, preferably, —COOH; and i is an integer from 0 to 4, preferably 1 or 2.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: September 23, 2003
    Assignee: Sigma-Aldrich Co.
    Inventors: William K. Kappel, Venkatappa Viswanatha, Handong Li, Richard J. Mehigh, John G. Dapron