Abstract: Systems and methods of automatically detecting styles of properties of DOM elements of an information resource are disclosed. A data processing system including one or more processors can identify an information resource for which to automatically detect styles of properties used to style primary content of the information resource, identify at least one DOM container that contains at least a portion of the primary content, determine, for each of one or more DOM elements included in the DOM container, styles of properties corresponding to a respective DOM element, store, in a memory, the determined styles of properties corresponding to the respective DOM elements included in the DOM container and use the stored styles of properties to modify third-party content to be inserted within the information resource.

Abstract: Systems and methods of automatically detecting styles of properties of DOM elements of an information resource are disclosed. A data processing system including one or more processors can identify an information resource for which to automatically detect styles of properties used to style primary content of the information resource, identify at least one DOM container that contains at least a portion of the primary content, determine, for each of one or more DOM elements included in the DOM container, styles of properties corresponding to a respective DOM element, store, in a memory, the determined styles of properties corresponding to the respective DOM elements included in the DOM container and use the stored styles of properties to modify third-party content to be inserted within the information resource.

Abstract: Systems and methods of automatically detecting styles of properties of DOM elements of an information resource are disclosed. A data processing system including one or more processors can identify an information resource for which to automatically detect styles of properties used to style primary content of the information resource, identify at least one DOM container that contains at least a portion of the primary content, determine, for each of one or more DOM elements included in the DOM container, styles of properties corresponding to a respective DOM element, store, in a memory, the determined styles of properties corresponding to the respective DOM elements included in the DOM container and use the stored styles of properties to modify third-party content to be inserted within the information resource.

Abstract: Systems and methods of automatically detecting styles of properties of DOM elements of an information resource are disclosed. A data processing system including one or more processors can identify an information resource for which to automatically detect styles of properties used to style primary content of the information resource, identify at least one DOM container that contains at least a portion of the primary content, determine, for each of one or more DOM elements included in the DOM container, styles of properties corresponding to a respective DOM element, store, in a memory, the determined styles of properties corresponding to the respective DOM elements included in the DOM container and use the stored styles of properties to modify third-party content to be inserted within the information resource.

Abstract: The present invention provides devices, small interfering RNAs, and methods for treating a neurodegenerative disorder comprising the steps of surgically implanting a catheter so that a discharge portion of the catheter lies adjacent to a predetermined infusion site in a brain, and discharging through the discharge portion of the catheter a predetermined dosage of at least one substance capable of inhibiting production of at least one neurodegenerative protein. The present invention also provides valuable small interfering RNA vectors, systems, and methods for treating Huntington's disease in vivo without impairment of cell endoplasmic reticulum, spontaneous motor activity, or locomotor activity of a patient.

Abstract: Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatta and Homo sapiens. These sequences, molecules and methods aid in the study of the pathogenesis of HD and can also provide a treatment for this disease.

Abstract: The present invention relates to reagents, methods and systems to treat heart failure using small interfering RNA (siRNA) molecules targeted to phospholamban.

Abstract: The present invention relates to devices, systems, and methods for improving memory and/or cognitive function by brain delivery of compositions of small interfering RNA or vectors containing the DNA encoding for small interfering RNA. Such compositions can be administered using devices, systems and methods for direct delivery of the compositions to the brain, or using devices, systems, methods of delivery, and compositions that deliver small interfering RNA or vectors containing the DNA encoding the small interfering RNA across the blood-brain barrier. The present invention also provides valuable small interfering RNA vectors, and methods for reduction of BACE1 levels in the hippocampus, cerebral cortex, or other regions of the brain that have beneficial effects on improving memory and/or cognitive function in a subject.

Abstract: A tip delivery system includes a tip, a tip support structure and a dissolvable joint connecting the tip to the tip support structure. To separate the tip from the tip support structure, a dissolving liquid is delivered to the dissolvable joint. The dissolving liquid reacts, e.g., enzymatically, with the dissolvable joint and dissolves the dissolvable joint.

Abstract: The present invention provides medical devices and methods for delivering compositions to cells. The compositions include an artificial viral vector, and particularly, an artificial adeno-associated virus vector. Such compositions can be useful for delivering the artificial viral vector across the blood-brain barrier.

Abstract: The present invention is directed toward methods for regulating biological pacemaking activity and devices used in such regulation. Such regulation can be accomplished by introducing genetic material to the heart by transfecting heart cells of the atrium or ventricle with an oligonucleotide, small interfering RNA, that silence KCNJ2, and suppress the IK1 current. Suppression (or silencing) of KCNJ2 subsequently induces pacemaker-like activities in previously regular myocytes. This invention provides for methods of targeted delivery using a fluid delivery catheter. Such a catheter allows the targeting of a specific area in the atrium or the ventricle of the heart. Also, combination methods of treating arrhythmia with traditional device-based therapies (e.g., pacemakers and defibrillators) and an oligonucleotide of the subject invention.

Abstract: The present invention is directed to methods and systems for the treatment of inborn genetic errors or other defects that cause deficiencies of active enzymes or proteins within the cells of the central nervous system. Such methods and systems generally comprise an implantable catheter system designed for the chronic delivery of specially formulated proteins to intrathecal, intracerebroventricular, and/or intraparenchymal regions of the central nervous system. The invention has application in the neuropathic aspects of the broad category of lysosomal storage diseases. These genetic based diseases are the result of insufficient enzyme activity to catabolize specific substances, which thereby accumulate in the cellular lysosomes.

Abstract: Methods and apparatuses for delivering RNA polynucleotides to a patient in need thereof are described. Programmable infusion pump systems that include a reservoir housing the RNA polynucleotide are implanted in the patient. The RNA polynucleotide is delivered to a target location in the patient via a catheter in communication with the reservoir. The pump system may include one or more sensors that may control rate or timing of delivery of the RNA polynucloetide based on a detected event. The pump system allows for controlled delivery of RNA polynucleotides for the treatment of diseases, disorders, or conditions.